Letter of Intent Template
HSC 4730 Health Science Research
Florida State College at Jacksonville
Request for Proposal (RFP) from the National Institute of Health (NIH)-Choose One Pharmacokinetic and Pharmacodynamic Studies for Medications Development Transmission of Human Immunodeficiency Virus (HIV) In Semen Getting from Genes to Function in Lung Disease. X Developmental Mechanisms of Human Structural Birth Defects Eunice Kennedy Shriver National Institute of Child Health and Human Development Nanoscience and Nanotechnology in Biology and Medicine
Place an “X” in the box next to the RFP topic to which the proposed research is most relevant. Mark only one subtopic. …show more content…
There was a broad consensus for five priority areas for future research, to integrate approaches across different technologies and to include diverse populations for future human studies. There is a need for creating new collaborations with versatile teams that combine bioinformatics, genetics, molecular biology, and cell physiology.
This is a summary to discuss the direct relevance of the proposed research topic to selected subtopic. You should include the following:
-explain the problem you are trying to solve
-your basic approach to solving the problem
-what solution you expect (if any)
-the impact this will have Getting from genes to function in Lung Disease Recent results from genome wide association studies show that lung-relevant phenotype have emphasized how powerful the shortcomings are in their approach. Even though new genes and changes have been identified a large part has still been unidentified. As well as, in the disease development the function and mechanisms of how they develop the disease is still unknown. The National Heart, Lung, and Blood Institiute assembled a 2 day workshop to address the shortcomings and consider future directions for lung phenotypes.
· Background and rationale
The ultimate goal of the workshop was to provide recommendations to the Institiute to fill in the gaps of the knowledge of lung disease genetics by applying different approaches.The workshop covered
Health care is a fundamental element to sustaining the welfare of our society. The ability to become a student in the Grand Canyon University (GCU), Master of Science in Family Nurse Practitioner (FNP) program, takes me one step closer to being able to achieve my dream of playing a vital role in helping our society towards disease prevention. My experience in the acute care setting has reinforced my passion in disease prevention and health preservation. My short term goal is to be able to successfully complete the required course work. Secondly, I want to be able to acquire the necessary certifications to be able to practice as a FNP. The program at GCU will provide me with the knowledge, and skills I will need to effectively develop my role. The long term goal I have set for myself is to reach the Doctorate level degree at some point in my career. I would like to practice at an independent level and have my own practice in
Emphysema is the most common cause of death from respiratory disease in the United States and is generally caused by several years of heavy cigarette smoking (Olendorf, 2000). When a person smokes, the body’s immune system tries to fight off the invading smoke by using certain substances. These substances can also attack the cells of the lungs, but normally the body is able to release other substances to prevent this. In the case of people who are smokers, this doesn’t happen and the original substances that were released to fight off the smoke also end up injuring the cells of the lungs as well. Eventually, the lungs will not be able to supply enough oxygen to the blood and a host of problems can occur with this. Risk factors that have been identified for emphysema include exposure to tobacco smoke either through active or passive smoking (2nd hand smoke), occupational exposure such as dust or chemicals, ambient air pollution, or genetic abnormalities, including a deficiency of alpha-antitrypsin, an enzyme inhibitor that normally counteracts the destruction of lung tissue by certain other enzymes (Smeltzer, 2010). The symptoms of emphysema develop gradually over many years. It is generally characterized by three primary symptoms: chronic cough, sputum production, and dyspnea on exertion. Other signs and symptoms include weight loss and the development of a
Premature birth has been linked to a vast array of lungs problems, the earlier the birth the greater risk of health complications(Davis R and Mychaliska G, 2013). A majority of the health problems will affect the infant for the rest of their life (Davis R and Mychaliska G, 2013). Infants born between the canalicular and the saccular period (week 25) have lung development that is unsuitable for gas exchange (Davis R and Mychaliska G, 2013). Two major complications that arise with undeveloped lungs is bronchopulmonary dysplasia, and pulmonary arterial hypertension (Mahgoub L. et al. 2017).
COPD is one of the greatest causes of disability and mortality in the twenty first century with future predictions painting an even graver story. Occupation, genome, and primarily smoking are the main causes of COPD. COPD is the third leading cause of death in America, claiming the lives of 134,676 Americans in 2010. Symptoms are typical of a constant smokers cough which progresses into the debilitating palliative stage of the disease; the development of co-morbidities exacerbates these symptoms. COPD has a complex pathophysiology involving hyperinflation, excessive mucus production and airway remodeling; diagnosis is through lung function tests. COPD is poorly managed with few effective treatments and a poor
Cystic Fibrosis is a genetic disease which is progressive and limits breathing ability. The lungs and other organs are affected by a thick buildup of mucus. This mucus traps bacteria which leads lung damage, infections, and respiratory failure. The digestive enzymes being released is prevented, affecting the breakdown of food and nutrients being absorbed. ?More than 30,000 children and adults in the United States have Cystic Fibrosis. 70,000 people worldwide.? (Diagnosed With Cystic Fibrosis, Cystic Fibrosis Foundation) Someone who has Cystic Fibrosis have a defective gene from each parent which produces faulty protein. The CFTR gene is the gene that is mutated causing this. The channel that transports chloride in and out of cells is created by instructions that are created by CFTR gene. The regulation of chloride ions and water are prevented creating the thick mucus formed on the passageways of lungs, pancreas, and other organs. Cystic Fibrosis doesn?t cause learning problems are mobility of the person. Babies with this still develop and grow up normally. The average life expectancy is close to 40 years, and has been increasing in the last fifty years thanks to improved care. ?Chronic coughing, recurring chest colds, wheezing, shortness of breath, frequent sinus infections, and allergies that last all year, are the most common symptoms of Cystic Fibrosis.? (Cystic Fibrosis Symptoms) Since this disease is progressive
All over the world, chronic obstructive pulmonary disease (COPD) is a very significant and prevalent cause of morbidity and mortality, and it is increasing with time (Hurd, 2000; Pauwels, 2000; Petty, 2000). Due to the factor of COPD being an underdiagnosed and undertreated disease, the epidemiology (Pauwels, Rabe, 2004) is about 60 to 85 % with mild or moderate COPD remaining undiagnosed (Miravitlles et al., 2009; Hvidsten et al., 2010).
Chronic Obstructive Pulmonary Disease (COPD) is a long term respiratory disease. It is characterised by a slowly progressive irreversible airflow obstruction that is due to a loss of lung elasticity resulting from parenchymal destruction and peripheral airflow obstruction. It is estimated that 80 % to 90 % of all cases of COPD are caused by cigarette, but it can also be caused by genetic disorders. Identification of genetic markers that predict the rate of loss of lung function may help in disease prevention and improved management in the future (1).
Emphysema is a disease of the lungs that consist of the over-inflation of the air sacs, otherwise known as the alveoli. The normal functioning of the alveoli helps in ordinary breathing. Unlike other lung infections this one can be passed on genetically. This disease can affect people of all genders, race and age. Statically, the number of males with emphysema is more numerous than the females by fifty four percent. Nevertheless, in the two years that trailed the difference amongst males and females declined by ten percent. Emphysema is categorized as a C.O.P.D also known as chronic obstructive pulmonary disease.
Human lungs were donated for medical research by the Gift of Life Donor Program from deidentified control non-smoker and smoker organ donors. We selected donors with lung function with a PaO2/FIO2 ratio of >250, a clinical history and x-ray that did not indicate infection, and limited time on a ventilator. Non-smokers were individuals who never smoked and smokers smoked 5-20 cigarettes per day for at least 3 years. Lung tissue from patients with emphysema (GOLD IV) was obtained from lung volume reduction surgery through Temple Biobank at Temple University, Philadelphia, PA (N = … per group). ATII cells were isolated as we previously described (REF). Briefly, after elastase (Roche Diagnostics,
Pulmonary Fibrosis is a condition where the lung tissue becomes thick and scarred, but it is more serious than just thinking you have scarring on your lungs. The thickening and scarring of the lungs makes it hard for the oxygen supply to be delivered throughout the body. This disease can develop slowly or quickly and can stay the same for years. Pulmonary fibrosis occurs in a variety of clinical settings, is a major cause of mortality, and represents an enormous medical need. However, the disease is heterogeneous and the failure to distinguish different types of fibrosing lung diseases can lead to inaccurate treatments. Pulmonary fibrosis occurs in the context of connective tissue diseases that are often characterized by a distinct pattern
The genetic analysis, lung biopsy methods particularly in new children as little as 3 kg, (Robin R .Deterding. 2010). And the new clinical as well pathological classification framework for diffuse lung diseases in children have enhanced diagnostic capacities and modified the diagnostic standards in chILD (Claire
Around 1944, scientists discovered that the widespread defect of mucous secretions could have a big explanation for the many symptoms of cystic fibrosis (Shapiro & Heussner, p.17). There was are pattern of recessive inheritance patter that was proposed in 1946 (Todd 2001), by the 1950s many advancements have been made, such as diagnosis and even the development of the sweat test and successful treatments for lung infections by using antibiotics (Shapiro & Heussner, p.17). In the year 1985,
By separating the twins based on zygosity, researchers were able to determine how smoking affected both groups. Other factors that were taken into consideration included smoking starting age, number of cigarettes daily, depth of inhalation, and type of cigarette (2). The study suggests that inherited predisposition does not have a substantial role in the vast majority of smoking-induced lung cancers in men older than 50 years.
Smoller also explains, “[t]hese resources create opportunities for focusing genetic studies on biological pathways…[in] evaluating the functional significance of risk loci that may [identify] in the future” (Smoller, p. 310). He also distinguished,