Literature Review Paper On Progeria

1072 Words5 Pages
Abstract After a while of searching about progeria, we have found that there are two types of progeria Hutchison-Gilford and Werner Syndrome. They both have the same mutation and symptoms, but they differ in the time the mutation occurs, but still, there is not any specific cure for it yet. Also, we have found that progeria is not related to family disorders’ history like other mutations. The mutation actually happens randomly at a rate of one of four to eight million people. Introduction Progeria is one of the rarest and weirdest diseases that was found by Dr. Jonathan Hutchison in the United Kingdom in 1886. It starts to appear at the age of nine to twenty-four months. It is caused by a problem in the genes that occur rarely to people at a rate of one of four to eight million.…show more content…
Progeria is so unpopulated disease since it is so harmful but there are not many people who know it and there are not many kinds of research about it. Progeria has no specific cure yet and that is the reason that makes progeria so dangerous. Literature Review There are two types of Progeria. They are Hutchison-Gilford Syndrome (HGPS) and Werner Syndrome, and the most common type is HGPS. According to MNT, Medical News Today, “Progeria is a rare genetic condition that causes a person to age prematurely. Children with progeria appear healthy, but by the age of 2 years, they look as if they have become old too fast”. A single gene mutation is responsible for progeria. The gene, known as lamin A (LMNA), makes a protein necessary for holding the center (nucleus) of a cell together. When this gene had a defect (mutation), an abnormal form of the lamin A protein called Progerin is produced and makes cells unstable. Unlike many genetic mutations, progeria is rarely passed down in families. (Figure 1 shows the mutation). (Figure 1 The

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