Liver Disease Research Paper

The MD Anderson Liver Tumor biospecimen resource has been invaluable for a large number of studies or clinical development. The sixth and subsequent editions of the American Joint Committee on Cancer (AJCC) staging of hepatocellular cancer, which was developed by an international consortium led by Jean-Nicolas Vauthey, MD, Professor of Surgery at MD Anderson and co-leader on project 2 of the SPORE, was based upon pathologic review of resected specimens in the Liver Tumor Bank (Vauthey JN J Clin Oncol 2002 20:1527-36). In addition, investigators at MD Anderson examined tissues in the Liver Tumor Bank to elucidate the prognostic significance of the ribonucleoprotein Human Antigen R (HuR) showing that patients with high HuR tumor expression had

How Drinking Causes Gut Microbe Imbalance Linked to Liver Disease is an article that builds on the common knowledge that alcohol consumption damages the liver. The liver is the organ in the body that filters out everything in your bloodstream that may harm you, for example alcohol. It also produces a substance called bile that breaks down lipids. For these reasons, the liver is a very important organ in the digestive system in the body and this article shows how alcohol damages it.

These functions range from protein production and blood clotting to cholesterol, glucose (sugar), and iron metabolism to processing what you eat and drink into energy and nutrients your body can use. The liver also removes harmful substances from your blood. As a result of alcohol abuse one can damage his/her liver thus preventing proper cleansing of the blood and other bodily fluids from harmful substances. Alcohol also destroys and damages liver cells. Your liver can also become damaged if you drink more alcohol than it can process.

Cirrhosis is a consequence of chronic liver disease characterized by replacement of normal, healthy liver tissue by fibrotic scar tissue, blocking the flow of blood through the organ and preventing it from working as it should, as well as regenerative nodules leading to progressive loss of liver function. The liver, the largest organ in the body, is vital in keeping the body functioning properly. It removes or neutralizes poisons from the blood, produces immune agents to control infection, and removes germs and bacteria from the blood. It

Liver produces bile, which helps to decompose lipid molecules, during digestion. It also produces certain proteins and cholesterol that are needed in the blood plasma, and that carry fats around the body. The liver stores iron, so if the liver is negatively impacted, it can lead to iron deficiency (Stanford Children’s Health 2015). Furthermore, it is vital is removing toxin from the body, so if the liver can’t function properly, the toxins will be left in the body, causing further damage. It also regulates blood clotting, so without the liver, the body won’t be able to stop bleeding in an injury, and blood may clot in arteries, which will lead to heart attack (Stanford Children’s Health

Liver plays a central role in transforming and clearing chemicals and is consequently susceptible to the toxicity induced from these agents. Chemicals that cause liver injury are termed hepatotoxins, and more than 900 drugs have been implicated in causing liver injury and it is the most common reason for a drug to be withdrawn from the market. Chemicals often cause subclinical injury to liver which may be manifest by abnormal liver enzyme tests. Certain medicinal agents when taken in overdoses and sometimes even when introduced within therapeutic ranges may injure the organ. Other chemical agents such as those used in laboratories and industries, natural chemicals (e.g. microcystins) and herbal remedies can also induce hepatotoxicity (e.g. Lycopodiumserratum and Ephedra equisetina).

With limited number or organs available to those in need of a new one, there must be a way in which people are granted their spot on the recipient list. Many factors in organ allocation must be considered as organs are a scarce resource. Such factors must include, life style, age, prognosis, other comorbidities and most importantly the cause for the transplant. To explore these ideas, I will focus on the Zambrano article introduced in class. In this article, the author explores the argument of responsibility in respect to people with Alcohol Related End of Stage Liver Disease (ARESLD). The argument of responsibility states that “alcoholics who have ARESLD should be given lower priority for (scarce) medical resources when they are competing

Liver cancer is an abnormal growth of cells (tumor) in the liver that is cancerous (malignant). The liver is located on the upper right side of the abdomen, just below the ribs. It is the largest organ in the body. The liver:

To purpose of this study was to determine the normal range of liver dimension and the relationship of each with sex, age, body height and weight in healthy children.

Despite the scientific progress in the field of liver disorders, hepatic fibrosis still remains a major medical problem with significant morbidity and mortality. Liver fibrosis is a reversible response that occurs in almost all pathological conditions associated with chronic hepatic injury (Malhi and Gores 2007). After a chronic liver injury of any etiology, the damaged hepatocytes, their membrane components, metabolites of toxic agents, and infiltrating inflammatory cells activate Kupffer cells, which release a number of soluble agents, including cytokines, such as platelet-derived growth factor (PDGF), transforming growth factor-b1 (TGF-β1), tumor necrosis factor-α (TNF-α), insulin-like growth factor-1 (IGF-1) and endothelin- 1 (ET-1), as

Foods that have folic acid are spinach, broccoli, lettuce, okra, asparagus, bananas, beans, yeast, mushroom, beef liver, kidney, orange juice, and tomato juice. Folic acid is been added also to breads, pasta, flour, cold cereal.

Alcohol can have negative effects on liver function. When alcohol is consumed the body starts trying to metabolize it but has no way of doing so. The liver then has to work detoxify and remove the alcohol from the bloodstream. Once the liver finishes the oxidation process, the alcohol becomes water and carbon dioxide. If the alcohol accumulates in the body, it may destroy cells and organs. The oxidative metabolism prevents this from happening. When too much alcohol is ingested at once, the toxins take a toll on the body, starting with the liver. The oxidative metabolism of the alcohol creates molecules that lead to a condition called fatty liver. Research supports that fatty liver, the early stage of alcoholic liver disease, develops in nearly

The liver is a large organ that has numerous crucial metabolic functions. It converts the nutrients from our diets into substances that the body can use, stores the

Liver disease is a big national problem. Millions of people have it. One of them is my Aaron, my brother. Aaron got diagnosed with liver disease in May 2016. We first noticed something was wrong when his running times were getting worse and worse. A couple days later he had yellow skin, so we took him to the doctor, and they sent us to a the Children's Hospital in Milwaukee. The doctor told us that he did have cirrhosis in the liver, which is a form of liver disease. Some people say just get a liver transplant, and some say they have to take medication. With the type of liver disease Aaron has. It won't matter if he gets a transplant. The new liver will get diagnosed again, and hde will have to do all the procedures and medication all over

Alcohol has no beneficial attributes on a person’s health. Alcohol can have several harmful effects on human organs. Some organs in the human body that are damaged by alcohol consumption are the brain, kidneys, and liver. The human liver is the one organ that suffers the most damage. As stated in an article published by the National Institute on Alcohol Abuse and Alcoholism, “Because the liver is the chief organ responsible for metabolizing alcohol, it is especially vulnerable to alcohol – related injury” (NIAAA, 2005). Regular use of alcohol can lead to alcoholic liver disease (ALD). The severity of ALD can vary based on several different factors. Some of these factors include gender, age, the amount consumed, and how often alcohol is used. “ALD includes three conditions: fatty liver, alcoholic hepatitis and cirrhosis” (Alcohol Alert, 2005).