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Major Depression Essay

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Depression and other mood disorders tend to proliferate as a result of multiple, complex, biological, psychological and social factors, including war and other violent conflicts, natural disasters, poverty and limited access to resources. An amalgamation of genetic and environmental factors unite to unchain depression (Sullivan et al., 2000; Wong and Licinio, 2001; Lesch, 2004; Hamet and Tremblay, 2005; Ebmeier et al., 2006). Several vulnerability genes of large or little effect, in relations with each other and in combination with environmental factors, generate susceptibility to the disorder. Individual’s "personal threshold or vulnerability to depression is a considerable determinant of depression. Some people are more likely to become more …show more content…

Traditional genetic linkage studies and candidate gene methods have been used with reasonably limited achievement in major depression. Genetic models of etiology commonly believe a large number of genes with comparatively little contributions to liability. Progresses in high genotyping and microarray method have made it more possible to discover genes with little effect sizes (Hong and Tsai, 2003). It is of particular clinical concerns those studies which are based on pathophysiological ideas (candidate genes) and in particular those that observe the possibility of patients to respond to particular treatments. Serotonin (5-HT) systems is involved in Genetic susceptibility because tryptophan reduction in healthy individuals is observed to stimulate depressive symptoms only if they have affected relatives (Benkelfat et al., 1994).Polymorphism in the serotonin transporter (5-HTT) gene are of more particular concern in depression. A polymorphism in the 5' promoter region consisting of a short (s) and a long (L) L-allele with the s-allele being related with reduced 5- HT transmembrane transport and decreased transporter mRNA has been

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