Malari A Growing Problem Around The World

Ecological factors that encourage the Anopheles mosquito, and thus also encourage the prevalence of malaria include: being near the equator, densely populated areas, warmer temperatures, standing water, maintaining water for irrigation and deforested areas. (Holy p.1)

About 1,500 cases of malaria are diagnosed in the United States annually, mostly in returned travelers” (Global Health - Division of Parasitic Diseases , 2010). Malaria risk is not distributed homogeneously throughout all countries. Some destinations have malaria transmission occurring throughout the whole country, while in others it occurs in defined pockets so the traveler should be weary of areas whose climate is conducive to mosquitoes.

Malaria has been in existence for thousands of years. Many historical records show that it has affected human civilization greatly by plaguing and causing mass death. The earliest record can be traced back to 2700 BC in China (Cox, 2002). It has been long associated with swamps and insects for hundreds of years but often believed to be the air from swamps causing the plague. The term malaria rooted from two Italian words ‘mala’ and ‘aria’ which literally means bad air. Humanity did not know the true nature of the long thought disease until 1894 when a Scottish physician, Sir Ronald Ross, discovered that it was actually the parasite in mosquito that is causing the malaria.

falciparum, whereas in most other countries with malaria transmission, other, less virulent plasmodial species predominate. Almost every malarial death is caused by P. falciparum.[ Malaria is caused by an infection with protozoa of the genus Plasmodium. The name malaria, from the Italian mala aria, meaning "bad air", comes from the linkage suggested by Giovanni Maria Lancisi (1717) of malaria with the poisonous vapours of swamps. This species name comes from the Latin falx, meaning "sickle", and parere meaning "to give birth". The organism itself was first seen by Laveran on November 6, 1880 at a military hospital in Constantine, Algeria, when he discovered a microgametocyte exflagellating. Patrick Manson (1894) hypothesised that mosquitoes could transmit malaria. This hypothesis was experimentally confirmed independently by Giovanni Battista Grassi and Ronald Ross in 1898. Grassi (1900) proposed an exerythrocytic stage in the life cycle, later confirmed by Short, Garnham, Covell and Shute (1948), who found Plasmodium vivax in the human liver.

Brian, G, Y., Greenwood, D, A., Fidock, Dennis, E, K., Stefan, H, I. Kappe, P., Alonso, L., Frank, H and Collins, P (2008) “Malaria progress and prospects for eradication.” Journal Clinical Investiment. 118: 1266-1276.

Malaria (also called biduoterian fever, blackwater fever, falciparum malaria, plasmodium, Quartan malaria, and tertian malaria) is one of the most infectious and most common diseases in the world. This serious, sometimes-fatal disease is caused by a parasite that is carried by a certain species of mosquito called the Anopheles. It claims more lives every year than any other transmissible disease except tuberculosis. Every year, five hundred million adults and children (around nine percent of the world’s population) contract the disease and of these, one hundred million people die. Children are more susceptible to the disease than adults, and in Africa, where ninety percent of the world’s cases occur and where eighty percent of the cases

Malaria is spread by the female Anopheles mosquito.When the mosquito bites the malaria parasite is passed into the human bloodstream, infecting them and this works both ways, if a human has previously been given the parasite and a unaffected mosquito bites them, the mosquito will pick up the parasite and spread it further. For the mosquito to survive it the humidity must be high, and the temperature must be between 15°C and below 40°C. Stagnant pools of water allow the mosquito to live. It uses areas like marshes, lakes and river pools to breed. Increasing population growth can encourage people to live closer to affected areas that were previously avoided, such as close to river pools. Normally the

Malaria is a disease that affects nearly 600 million people and causes more than a million deaths a year, the most coming from children under five. This disease is regularly found in more than 100 countries around the world and affects 40% of the world’s population. It is most commonly transmitted by an infected Anopheles mosquito. The most deadly form of malaria is known as Plasmodium falciparum because almost all deaths from malaria are caused by this specific one. Some of the symptoms that are affiliated with this strand of malaria are the destruction of red blood cells along with complications with the kidneys, lungs, and brain. In more serious cases, it can cause permanent neurological effects and even death. As the Nobel Assembly said at the announcement of the Nobel Prize in Physiology or Medicine, “Diseases caused by parasites have plagued humankind for a millennium and constitute a major global health problem. In particular, parasitic diseases affect the world’s poorest populations and represent a huge barrier to improving human health and wellbeing”. Youyou Tu, one of the winners of the prize, discovered Artemisinin, “a drug that has significantly reduced the mortality rates for patients suffering from malaria by killing the malaria parasites an early stage of their development.”

Before the research I knew malaria is a disease which occurs mostly in poor, tropical and subtropical areas of the world. I also knew people get malaria by being bitten by an infective mosquito.

Malaria has been a huge problem among many developing nations over the past century. The amount of people in the entire world that die from malaria each year is between 700,000 and 2.7 million. 75% of these deaths are African children (Med. Letter on CDC & FDA, 2001). 90% of the malaria cases in the world are located in Sub-Saharan Africa. Once again, the majority of these deaths are of children (Randerson, 2002). The numbers speak for themselves. Malaria is a huge problem and needs to be dealt with immediately.

Also, human population movement from higher transmission areas jeopardizes reintroduction and resurgence in malaria-free regions, and in addition has undermined elimination works in the past. For that reason, it is important to understand the patterns of parasite dispersal in order to target control by pinpointing regions where the imported infections originate from and where they play a part in transmission.

Malaria is considered one of the most serious and life-threatening public health problems in the world. According to World Health Organization, more than 3 billion people live in areas classified as being at risk from malaria, with nearly 200 million cases.1 Approximately, 750,000 deaths occur every year, primarily among children, due to malaria and its complications.1 Children less than 5 years of age are more vulnerable to be affected by malaria.2 In 2015, about 438,000 malaria deaths were reported, of which estimated 69% were children under 5 years of age.2

Since it was first discovered in 1880 by French army surgeon Charles Louis Alphonse Laveran, Malaria has caused the suffering of millions each year. According to the World Health Organization It was estimated that in 2015 there were nearly 214 million cases of Malaria worldwide, half a million of which were lethal. Malaria is caused by a parasite which is transmitted through the bite of a mosquito. Although cases of Malaria are most common in the sub-Saharan Africa region, it has affected people on a global scale. Efforts to combat Malaria range from insecticide treated bed nets to indoor residual spraying. Although both methods are viable, they do not have to potential to eradicate Malaria. The most effective means of combating Malaria is through genetic modification of mosquitoes. By tinkering with the genes of the very creature who transmits the parasite, we can ultimately eliminate the disease before it even poses a threat.

In 2015, approximately 3.2 billion people, which is almost half of the world 's population, were at risk of being infected with Malaria. Most cases of malaria occur in sub-Saharan Africa however, Asia, Latin America, and, the Middle East are at risk but to a lesser extent. In 2015, 95 countries had relentless malaria spread, around 88% of the cases and 90% of deaths where in Africa. The pattern between most countries is that they are low or middle income countries. Those who do not have access to proper health care are the ones who are most affected by the disease. Even in sub Saharan Africa the three countries with the highest death from malaria are among the poorest in the region. The high cases and death rates in Africa is caused by different reasons.

About 3.3 billion people, that is about half of the world’s population are at risk of contracting malaria (figure 1). Every year there are 250 million cases of malaria, and nearly 1 million deaths. That amounts to 2,732 deaths per day. Out of those million people that die every year, 800,000 of them are African children under the age of 5. To control malaria three actions need to be taken: insecticides need to be used to decrease the vector population, people have to be educated as to how to prevent the vector from reproducing, and anti-malarial drugs need to be distributed. To understand the vector and what the vector is, scientists had to first discover what the parasite was and how it worked. It was not until the year 1880 that French Physician Charles Laveran discovered that Malaria was caused by a protozoan in the genus Plasmodium (Malaria, 2013)