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Mdx Research Paper

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CHRONIC MILD TO MODERATE TOXICITY (MDX): Toxicity can range from asymptomatic ALT elevation to malaise, nausea, vomiting, abdominal pain, and hepatotoxicity.
CHRONIC SEVERE TOXICITY (MDX): Jaundice, hypoglycemia, coagulopathy, renal failure, fulminant hepatic failure and encephalopathy.

Presentation following chronic acetaminophen overdose typically includes 4 phases (MDX):
(1) Anorexia, nausea, vomiting, malaise and diaphoresis;
(2) First phase signs resolve, replaced by right upper quadrant pain, liver enlargement, oliguria in some patients, elevated bilirubin and hepatic enzyme levels, and prolonged prothrombin time;
(3) About 3 to 5 days into the course, anorexia, nausea, vomiting, and malaise reappear along with signs of hepatic failure (jaundice, hypoglycemia, coagulopathy, and encephalopathy) and sometimes, renal failure and cardiomyopathy;
(4) Either recovery or progression to death due to liver failure finally occurs; …show more content…

Management of Toxicity/Overdose [Monitor vital signs and mental status in all patients]
Acute Tylenol overdose (MDX):
- Patients who present “early” (within 8 hours of ingestion) only require a serum acetaminophen determination. In those patients who require acetylcysteine treatment, liver enzymes, serum electrolytes, and renal function should be monitored.
- Patients who present with an unknown time of ingestion or more than 8 hours after an ingestion should have a serum acetaminophen determination, electrolytes, renal function tests, liver enzymes and an

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