Multiple Sclerosis (PPMS)

Multiple sclerosis (MS) involves an autoimmune process that develops when a previous viral insult to the nervous system has occurred in a genetically susceptible individual. B lymphocytes, plasma cells, and activated T cells, along with proinflammatory cytokines, cause inflammation, oligodendrocyte injury and demyelination. Early inflammation and demyelination lead to irreversible axonal

Multiple sclerosis, also known as MS, is one of humankind’s most mysterious diseases. No one knows the exact cause and there is no exact treatment. Still multiple sclerosis has the ability to affect nearly 3 million people worldwide and at least 500,000 people in the United States (Boroch). This disease tends to be more common in individuals of northern European descent and women are more than twice as likely to develop multiple sclerosis as men. Of those 3 million people, most of them are between the ages of 20 and 50 years old (Dangond). Even though multiple sclerosis is a mystery disease, scientists are working to determine the exact cause and treatment.

There are many debilitating side effects and symptoms that accompany Multiple Sclerosis (MS). In MS, the immune system essentially fights itself and attacks its own body’s cells, causing progressive damage in the brain and spinal chord. Some key symptoms and side effects of the disease are vision problems, muscle weakness, and trouble walking or speaking. However, this is not it, There are many more side effects and symptoms that very between individuals. Some of the symptoms that haven't thoroughly been researched are the changes that occur in the brain of an MS patient, especially a pediatric MS patient. There are several existing hypothesis about Multiple Sclerosis’ debilitating effects in the brain, but no concrete research done on the

Multiple Sclerosis (MS) is a neurologic disease that affects the Central Nervous System (CNS) through cellular immune response and the demyelination of CNS white matter (McCance et al., 2014, pp. 630–633). The initial causes of MS are unknown however, it is believed that it could possibly be due to an immune response to an initiating infection or an autoimmune response to CNS antigens on the myelin itself (Brück, 2005) (Miljković and Spasojević, 2013). MS is a result of the degradation of the myelin sheath surrounding neurons and therefore disrupts the transmission of action potentials along these cells. MS can display itself in the form of symptoms ranging from muscle weakness to trouble with sensation and coordination (NHS, 2016). The degradation of myelin leads the body to attempt to remyelinate the neurons, a process that in turn leads to the thickening of the cell by glial cells and this causes lesions to form (Chari, 2007). It is this thickening (sclerae) from which the disease gets its name. Sufferers of MS can either have a relapsing type of MS, in which there are episodes that lead to the worsening of symptoms for a period of time, or a progressive type of MS where symptoms gradually progress and worsen (McCance et al., 2014, pp. 630–633).

It is suggested by previous studies that the damage of the myelin sheath in MS involves the activation of inflammatory factors including the CD4+ T cells, CD8+ T cells, B cells, macrophages and microglia cells (Luccinetti et al., 1996; Lassmannet al., 2012). However, whether the immune response triggers the onset of MS, or is a consequence of the disease process is currently not clear. Interestingly, several recent studies suggested that the prevalence rate of MS is significantly increased with latitude, which implies that not only the geographical (environmental) differences but racial and ethnic differences may play a role in the worldwide MS distribution (Rosati, 2001; Simpson et al., 2011).

Multiple sclerosis is a chronic, progressive neurological disease affecting all aspects of life: physical, cognitive, emotional, and social (Abma). It is known as an autoimmune disease, Where the body’s immune system turns against the body and destroys the protective covering that surrounds nerve cells. This damage to the nerve cells causes many problems for the patient including weakness, muscle stiffness, poor coordination and balance, tingling, numbness, tremors, blurred vision, slurred speech, and memory and concentration problems (Bren)

Multiple Sclerosis, commonly known as MS is an autoimmune disease of the central nervous system. Scientists have been studying MS since the 19th century. In MS, the body’s immune system produces cells and antibodies that attack myelin in your brain which is essential for the nerves in your brain and spinal cord to conduct electricity to perform its function. The attack on myelin results in vison loss, paralysis, numbness, muscle weakness, difficulty walking, stiffness, spasms, and bladder and bowel problems. MS has varying degrees of severity and affects people between the ages of 20-50, mostly women. Although there are treatments, there is no cause and cure yet.

Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord, particularly the central nervous system (CNS). In MS the immune system attacks the myelin, which is the protective sheath that covers the nerve fibers and causes communication between your brain and the rest of your body. Eventually, the disease can cause the nerves to deteriorate or even lead to permanent damage. They deteriorate in variable degrees and produce significant disability within 20-25 years in more than 30% of patients, (Luzzio, 2016). The majority of people diagnosed with MS are adults between the ages of 20 and 45; twice as many women are affected compared to men. However, MS can present itself in childhood or late middle age, but is uncommon. According to Goldenberg (2012), there is no known cause for this debilitating disease, but it appears to involve a combination of genetic susceptibility and a nongenetic trigger, such as a virus, metabolism, or environmental factors

Multiple Sclerosis (MS) is a lifelong disorder of the central nervous system: that consist of the brain and spinal cord. MS is known as an autoimmune disease in which the immune system mistakenly attacks myelin sheath. The myelin sheath is the cover that protects the nerve cells. When the myelin is damaged, messages between the brain and the whole body get disrupt. MS is more probable to affect people between the ages of 20 to 40 years. The effects of the disease vary for everybody who suffers from it. Depending on this the disease may progress rapidly or slowly. MS has four different categories of progressing. Unfortunately, MS is an incurable disease, but treatments such as medication and physical therapy can help comfort and regulate the symptoms. In this essay, I will talk about the progression of the four types of MS and the stages of diagnosis.

Multiple Sclerosis (MS) is a rare disease that directly disables the central nervous system (CNS). While there has been some recent studies, there still isn’t enough research for scientist to classify the exact causes of MS. However, all researchers declare that the causation of MS is a direct impact of the disease “attacking” the central nervous system, which leads to a disruption of the flow of information within the brain, and between the brain and body (National MS Society). When there is a disturbance within the CNS, signals within the brain and from the brain to the body are altered, which can have devastating effects on patients. MS is a mysterious disease that still has a lot of research to be conducted in order for scientist and doctors

This investigation reveals that significant emphasis is laid on the relapses in multiple sclerosis, but relapses do lead to the development of permanent disability. Relapses include flare-ups followed by periods of remissions. These are caused by inflammation that takes place in the central nervous system (CNS), where it causes damage to the myelin sheath, thereby disrupting the nerve impulses

Rolak, L. A. (2003). Multiple Sclerosis: It’s Not the Disease You Thought It Was. Clinical

Multiple sclerosis (MS) is a degenerative and potentially debilitating disorder that affects the spinal cord and brain, collectively known as the central nervous system. Multiple sclerosis evolves gradually throughout time and is considered to be auto-immune, which means the immune system mistakenly attacks healthy cells and tissues that are supposed to be within the body. According to Medscape, symptoms consist of, but are not limited to, sexual problems, ataxia (the inability to control certain muscle movements as defined by Tortora and Derrickson), fatigue, and optic neuritis. Multiple sclerosis is characterized into four different types: relapsing-remitting MS, secondary-progressive MS, primary-progressive MS, and progressive-relapsing MS. There is currently no cure for multiple sclerosis, but there are many forms of treatments to help suppress the symptoms and hinder the progression. The Patient Education Institute lists of treatments include prescription medication and healthy lifestyle habits, such as exercising. Steroids are also administered to delay the severity of the attacks. The aforementioned details about the treatments, types, and symptoms of multiple sclerosis are merely a superficial analysis. To fully understand this disease, a more in-depth and detailed focus of its impact within the body is needed.

Multiple sclerosis (MS) has effective and safe treatment options, such as disease-modifying treatments (DMTs), which reduce symptoms and improve long-term outcomes such as lowering risks for MS-related hospitalization, MS-related disability [often measured using Expanded Disability Status Scale (EDSS)], MS relapse, and lessening MS-related medical costs in patients affected with Relapsing-Remitting MS (RRMS). Despite the availability of various treatments in the market for treating MS, consensus about the effectiveness of these treatments is still lacking as very few clinical trials conducted head-to-head comparisons of these treatments.

Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the CNS and the most frequent cause of nontraumatic neurological disability in young and middle-aged adults (1). Women are twice as likely to be affected as men, and onset typically occurs between the ages of 20 and 40 years (2). The diagnosis Depend on a detailed history; careful neurological examination; and supportive paraclinical investigations. According to the new McDonald criteria, the diagnosis of MS requires objective evidence of lesions disseminated in space and time.MRI findings may contribute to the determination of dissemination in time or space (4).)