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Mutational Supply

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Mutational supply
There are two types of mutational supply constitutive and environment-specific mutators. For constitutive mutators adaptive evolution fundamentally relies on mutation to cause genetic variation. So it is not too far of a stretch to consider an organism that elevates its rate of mutation could benefit from increased evolvability. Population genetic models reflect that in poorly adapted populations, genes that increase the genomic mutation rate, mutators, have the ability to spread through hitchhiking with the advantageous mutations they produce (Johnson 1999, Sniegowski et al. 2000). Even though this is more likely to occur in organisms that lack recombination so the association between the mutator and mutation is not denatured …show more content…

(1999) have shown how the rate of mutational supply frequently will not limit the rates of adaptation. Adaptation could be limited by the rate of that beneficial mutations can be fixed in large populations with abundant advantageous mutations available (Colegrave and Collins 2008). Advantageous mutations that are derived in different lineages compete with one another in asexual populations, and cannot be fixed together (Gerrish and Lenski 1998). This is known as clonal interference and may be a significant limit to the rate of adaptation in asexual populations. Syngamy and meiosis, parts of the eukaryotic sexual cycle, allow for advantageous mutations to arise in different lineages to be combined into the same individual (Colegrave and Collins 2008). This may circumvent the problem of clonal interference while increasing the effectiveness of selection. The mechanisms of syngamy and meiosis seem to be designed to increase variation of the offspring. In the past the purpose of sex was to increase the ability of a species to evolve was accepted with without question (Colegrave and Collins 2008); however, more recently this explanation has been questioned due to the expected costs of sex on the individual outweighing the benefits to the species (Colegrave and Collins 2008). With that said, Charlesworth and Barton (1996) proposed genetic modifiers for sex had a correlation with the rate of adaptation: an increase …show more content…

Even though the shapes of fitness landscapes have been examined by using experimental evolution in bacteria, few experiments look into how selection effects their shape (Colegrave and Buckling 2005). Therefore, future research should focus on using experimental evolution to provide insight on the potential of this type of selection by investigating the constraints on landscapes directly. On the other hand, there is evidence of how epistasis affects evolvability. Moore et al. (2000) and Sanjuán et al. (2005) demonstrated how the rates of fitness recovery in viruses and E. coli are affected by epistatic interactions. Epistasis and the rate of fitness were also found to have an be directly correlated and have an inverse relationship (Colegrave and Collins 2008). However, it is unclear if selection is directly affecting evolvability. Experimental evolution could be used to test the correlation between changes in epistasis and evolvability by testing if mutations are fixed in populations with varying evolvability as well as from differing

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