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NICE Review Essay

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Impact of the NICE guideline recommending cessation of antibiotic prophylaxis for prevention of infective endocarditis: before and after study: A Review Thornhill et al.’s article on the cessation of antibiotic prophylaxis and its impact on infective endocarditis examined, both, prescriptions for antibiotics of a standard premedication dose (3g amoxicillin or 600mg clindamycin) and diagnoses or deaths due to infective endocarditis between January 2000 and April 2010. The time frame chosen for this study was critical due to the release of updated NICE guidelines, stating providers should cease use of any antibiotic prophylaxis for dental and other medical procedures. By examining the time surrounding the NICE guidelines, the researchers hoped to evaluate any relationship between premedicative prescriptions and incidents of infective endocarditis. They hypothesized that in order to see evidence that the NICE guidelines were valid, there would be minimal to no change in rate of infective endocarditis after the NICE guidelines became effective compared to before, even though the amount of prescription decreased. The researchers felt that this study was necessary due to the limited large-scale studies relating to recent changes in …show more content…

The two most significant weakness related to the lack of specificity in etiological origin of the endocarditis, and an expanded discussion in relevance of results. The researchers explained that due to gathering their data from hospitals there was often a lack in specificity of microorganism identification in the codes submitted. More importantly, the researchers largely discussed the limitations in their study, rather than discussing the uses and significance of the article. While it is good to identify possible sources of error, the researchers overly focused on this, decreasing the confidence for readers in their

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