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Opioid Research Paper

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OPIOIDS – OPIUM, OPIATES, AND OPIOIDS Opioids and opiates are both derived from opium, a substance in the seeds of the poppy plant. Opiates are the drugs that represent opium in its purest forms, and opioids are synthetic and semi-synthetic formulations of natural opiates (4).
Cultivation of the poppy plant for harvest of its seeds can be traced as far back as 3400 B.C. (1.) Sumerians in lower Mesopotamia referred to the opium in the seed capsules “gil,” meaning joy, and the poppy “hul gil,” plant of joy. From Sumeria, the plant of joy was introduced to Europe. Around 460 – 357 B.C., Hippocrates, “The Father of Medicine”, acknowledged opium’s usefulness as a narcotic and styptic in treating internal diseases, diseases of women, and epidemics. …show more content…

Paracelsus, the founder of toxicology, discovered a specific tincture of opium that worked especially in reducing pain. He called this specific tincture laudanum, derived from Latin verb laudare, to praise. Today, the drug Laudanum still remains available by prescription. In 1806, morphine was discovered by German chemist Friedrich Wilhelm Adam Sertürner when he isolated the drug from opium. He named it morphine after the god of dreams, Morpheus. Morphine quickly became the staple for medical treatment of pain, anxiety, respiratory conditions, and “women’s ailments” (1). In fact, morphine was the most common pain killer during the Civil War, and because such an enormous number of soldiers became addicted to the opiate, the post-war morphine addiction prevalence became known as “Soldier’s Disease” (1) (3). The hypodermic needle was invented in 1853. This allowed morphine to be more easily used in minor surgical procedures as a painkiller and adjunct to general anesthetics, but also more easily abused (1) (2). People sought out a safer, non-addicting, and more effective alternative to morphine. In 1898, heroin was synthesized and claimed by German chemical company Bayer, to be a “non-addictive morphine substitute for medical use” …show more content…

According to a research study published in the Archives of Internal Medicine, “researchers found that people who took opioids were more than twice as likely to have heart attacks when compared to people who took no opioids at all”. The heart attacks are most likely due to the fact that the pills of opioids and opiates aren’t designed to dissolve in the bloodstream. Therefore, even when crushed, the fillers in the pills clump and clog the blood vessels, damming blood flow and destroying vital tissues. This also happens with liquid form opiates including heroin. The most times, the liquids are filled with contaminates that do not interact well with the bloodstream, including talc and coffee, causing blockage to and from the heart, leading to heart attack and death

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