OPIOIDS – OPIUM, OPIATES, AND OPIOIDS Opioids and opiates are both derived from opium, a substance in the seeds of the poppy plant. Opiates are the drugs that represent opium in its purest forms, and opioids are synthetic and semi-synthetic formulations of natural opiates (4).
Cultivation of the poppy plant for harvest of its seeds can be traced as far back as 3400 B.C. (1.) Sumerians in lower Mesopotamia referred to the opium in the seed capsules “gil,” meaning joy, and the poppy “hul gil,” plant of joy. From Sumeria, the plant of joy was introduced to Europe. Around 460 – 357 B.C., Hippocrates, “The Father of Medicine”, acknowledged opium’s usefulness as a narcotic and styptic in treating internal diseases, diseases of women, and epidemics.
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Paracelsus, the founder of toxicology, discovered a specific tincture of opium that worked especially in reducing pain. He called this specific tincture laudanum, derived from Latin verb laudare, to praise. Today, the drug Laudanum still remains available by prescription. In 1806, morphine was discovered by German chemist Friedrich Wilhelm Adam Sertürner when he isolated the drug from opium. He named it morphine after the god of dreams, Morpheus. Morphine quickly became the staple for medical treatment of pain, anxiety, respiratory conditions, and “women’s ailments” (1). In fact, morphine was the most common pain killer during the Civil War, and because such an enormous number of soldiers became addicted to the opiate, the post-war morphine addiction prevalence became known as “Soldier’s Disease” (1) (3). The hypodermic needle was invented in 1853. This allowed morphine to be more easily used in minor surgical procedures as a painkiller and adjunct to general anesthetics, but also more easily abused (1) (2). People sought out a safer, non-addicting, and more effective alternative to morphine. In 1898, heroin was synthesized and claimed by German chemical company Bayer, to be a “non-addictive morphine substitute for medical use” …show more content…
According to a research study published in the Archives of Internal Medicine, “researchers found that people who took opioids were more than twice as likely to have heart attacks when compared to people who took no opioids at all”. The heart attacks are most likely due to the fact that the pills of opioids and opiates aren’t designed to dissolve in the bloodstream. Therefore, even when crushed, the fillers in the pills clump and clog the blood vessels, damming blood flow and destroying vital tissues. This also happens with liquid form opiates including heroin. The most times, the liquids are filled with contaminates that do not interact well with the bloodstream, including talc and coffee, causing blockage to and from the heart, leading to heart attack and death
Throughout history men and women have been consuming psychotrophic substances for various purposes, including for relaxation, to achieve a state of euphoria, or to alter consciousness in order to find spiritual enlightenment. References to the opium poppy, which has been a major source of these psychotrophic substances, have been discovered in writings as far back as that of the Sumerians in 3300BC (Fernandez 1998:3). Opium has been used in various forms over the centuries for medicinal in addition to recreational purposes.
Opioids are prescription drugs such as oxycodone, hydrocodone and methadone just to name a few. Opioids are
The earliest form of painkillers was first created in the 16th century where people used laudanum or opium prepared in alcoholic solution as pain relivers. In the early 19th century, people extracted morphine from old opium poppy plants and this form of painkiller was most commonly used in the American Civil War. As Morphine was found to be very addictive, chemists in the 1870s produced heroin that did not turn out to be a success as it was proved to be more addictive than morphine. Many other synthetic opiates such as Vicodin, OxyContin, Percocet were produced respectively in 1984, 1995 and 1999. However, these synthetic opiates could only be given if prescribed by a doctor as they could also be addictive. There were also other options of
The opioid crisis was caused by a variety of factors, but the main reason why these drugs are in the spotlight is because of the actions of the drug manufacturers. In order to fully understand the spark of the opioid crisis, it is imperative to understand what makes these drugs so potent. Writer and crime journalist Sam Quinones states that opioids are synthetic drugs. Naturally sourced drugs, known as opiates, are derived from the opium poppy plant. However, experts use both of these terms interchangeably. The use of opioids grew around the late 90s, and legally, most people used these drugs for pain relief. However, the people that were using these drugs had little information as to how addicting opioids actually were. In fact, opioids are
As better and more comprehensive education is provided both to the general public and practicing clinicians the hope is to reduce the negativity surrounding the users of opioids, and to eliminate demeaning language coupled to them as well. This could improve patient morale and help the needless continuation of physical suffering within patients, as they would be more comfortable approaching and using opioids for therapeutic purposes1. That being said there are those within our communities who do abuse these substances and pharmacists must recognize the signs of abusers, it is important for them to reach out, without comment, to help those suffering from opioid abuse once they have been
These drugs are easy to become addicted to and continued use could lead to dependency. Citizen have to be sure to take drugs only prescribe to the patient on the bottle because what is safe to one person might not be to someone else. This is because our body chemistry is different for everyone.Some people are tricked into thinking it's safe because they are prescribed by doctors.This is untrue and opioid are very dangerous when taken recreational. Most opioids are given to help get through serious injuries. When you start these drugs, you can expect to experience drowsiness, slowed breathing, and constipation. The drug also will relieve the pain it was prescribed for. If long term usage occurs the user can easily become addicted. The body get used to the presence of these drugs and becomes attached. They might even need to use higher dosages to achieve the same high because the body builds up tolerance. This is how people overdose. The opioids slows the breathing so much that that stop breathing at
Oxycodone is the main drug I am concentrating on even though there are many opiates or schedule II drugs that are considered Opioids. Oxycodone was first created as part of an effort to find non-addictive alternatives to morphine and heroin, which were commonly used in medicine before World War I. Oxycodone is an opioid analgesic, ?Pain Killer? that is most often prescribed to control moderate to severe pain that must not be used with other medications. It is a slightly synthetic opiate that was created in 1916. The chemicals found in Poppy plants also make as morphine and heroin. Opiate:?A drug (such as morphine, codeine or heroin) containing or made from opium or the opium poppy, used to alleviate pain, or induce sleep or euphoria. ( A Forever Recovery. 2014. Web. 10 Mar. 2016). Opioid:?A synthetic or semi-synthetic substance producing an opium-like effect, often prescribed for the alleviation of moderate to severe pain; a prescription painkiller in the opiate class.
Analysis: Opioids are a class of drug that are medically used as very effective painkillers, like fentanyl and morphine, however, they are highly addictive and produce a feeling of euphoria (“Opioids”). This combination leads do a lot of abuse and dependency, where people take more than prescribed in order to feel better. People start off taking the opioid painkillers in order to not feel pain as prescribed by their doctors. Then, they end up getting addicted to them. There are also illicit opioids, such as heroin, that are also highly addictive and also lead to dependency and death (“Opioids”). These illicit versions are taken for recreational reasons, and are also often mixed with other drugs. The combination of taking an unregulated drug in conjunction with other drugs leads to a lot of overdoses.
Oxycodone is the main drug I am concentrating on even though there are many opiates or schedule II drugs that are considered Opioids. Oxycodone was created during the process to find a drug that was not addictive like morphine and heroin, which were commonly used in medicine before World War I(? A Forever Recovery. 2014. Web. 10 Mar. 2016?). Oxycodone is an opioid analgesic, ?Pain Killer? that is most often prescribed to control moderate to severe pain that must not be used with other medications. It is a slightly synthetic opiate that was created in 1916. The chemicals found in Poppy plants also make as morphine and heroin. Opiate:?A drug (such as morphine, codeine or heroin) containing or made from opium or the opium poppy, used to alleviate pain, or induce sleep or euphoria. ( A Forever Recovery. 2014. Web. 10 Mar. 2016). Opioid:?A synthetic or semi-synthetic substance producing an opium-like effect, often prescribed for the alleviation of moderate to severe pain; a prescription painkiller in the opiate class.
Oxycodone is the main drug I am concentrating on even though there are many opiates or schedule II drugs that are considered Opioids. Oxycodone was created during the process to find a drug that was not addictive like morphine and heroin, which were commonly used in medicine before World War I(? A Forever Recovery. 2014. Web. 10 Mar. 2016?). Oxycodone is an opioid analgesic, ?Pain Killer? that is most often prescribed to control moderate to severe pain that must not be used with other medications. It is a slightly synthetic opiate that was created in 1916. The chemicals found in Poppy plants also make as morphine and heroin. Opiate:?A drug (such as morphine, codeine or heroin) containing or made from opium or the opium poppy, used to alleviate pain, or induce sleep or euphoria. ( A Forever Recovery. 2014. Web. 10 Mar. 2016). Opioid:?A synthetic or semi-synthetic substance producing an opium-like effect, often prescribed for the alleviation of moderate to severe pain; a prescription painkiller in the opiate class.
The world of opioids can be divided into two categories: (1) illicit opioids and (2) prescription opioids. Illicit opioids include substances like heroin that people abuse to reach a euphoric and relaxed state. In contrast, prescription opioids are commonly used by doctors in a medical setting to treat pain. Some of these powerful painkillers include codeine, oxycodone, hydrocodone, morphine, and methadone. While these prescription medications provide pain relief for patients who are recovering from surgery or injuries, they also pose serious risks when they are misused. Among these risks are addiction, overdose, and death.
Opiates are derived by opium. Opium is a gummy substance collected from the seed of the opium poppy. This
It is necessary to provide a little background on the primary drug being discussed, heroin. Opium is not a new drug; it has been used in eastern cultures as far back as the Neolithic age. It was used then similarly as other opium based drugs today are used to control pain. Opium could be taken orally or by smoking it, both produce similar effects.
For thousands of years, opiates have been used in the treatment of pain. Opium is believed to have been discovered 6000 BC, and since then, it has had a huge impact on both medicine and the recreations of those seeking euphoria. More recent than the ancient discovery of natural opium are the derivatives of opium, such as the alkaloids morphine, codeine, and thebaine. From these alkaloids, semi-synthetic opiates can by synthesized, such as hydrocodone, and oxycodone. Synthetic opioids are also quite prevalent, which include fentanyl and tramadol. Opium can also be processed into heroin, a morphine derivative. As advancements were made in science and engineering to allow for a wider distribution and usage of opiates, the problems of dependence and overdose also increased drastically. According to Hart and Ksir (2013, p. 302), the invention of the hypodermic needle for intravenous administration of morphine and other drugs allowed for a much faster and more potent dose of the drug. With this increased potency came an increase in the possibility of a recreational intravenous user to overdose. Hart also mentions that some of the wars surrounding the era of the synthesis of morphine may have contributed to the rise of morphine, seeing as a medic soldier’s motto was always “first provide relief” (2013). This relief-driven attitude and extensive use of opioid analgesics in medicine during the time, in addition to the large amount of patent medicines and remedies on the market may
The misuse and abuse of prescription medications in the United States remains high, but few people are aware of just how big the problem really is. According to ASAM American Society of Addiction Medicine, "Drug overdose is the leading cause of accidental death in the US, with 55,403 lethal drug overdoses in 2015. Opioid addiction is causing this epidemic, with 20,101 overdose deaths related to prescription pain relievers, and also overdose deaths relating to heroin". Opioids are drugs which are prescribed to relieve pain. With continued use, the pain-relieving effects lessen and pain can become worse, so the body can develop dependence on the use of opioid. Opioid dependence causes withdrawal symptoms, which makes it difficult to stop taking