Pathophysiology Of FAS

The science behind FAS is quite simple; as it is known that alcohol has a damaging effect on the body, it has similar consequences on the fetus. Since the fetus is constantly developing, the alcohol causes more serious defects to the unborn child. Alcohol exposure to a fetus is known as a teratogen. “Teratogens are substances or conditions that disrupt typical development in offspring as a result of gestational exposure and cause birth defects.” (Wilson & Fraser, 1977). Although the exposure to alcohol causes problems in the fetus, studies have shown that it may not accurately be the alcohol in the mother’s system that causes these defects, rather the byproducts that form when the body metabolizes the alcohol. This can lead to a decrease in brain cells, abnormal location of neurons, and gross malformation to the brain. Since alcohol causes this central nervous system damage, it is classified as a neurobehavioral teratogen, which is a group of teratogens that cause brain damage and modify behaviors. (Riley & Vorhees, 1986). The CNS damage is the primary defect due to alcohol and it is quite common to have these damages without any physical abnormalities. The more alcohol that is consumed the more birth defects that will arise in the

Fetal alcohol spectrum disorder (FASD) is a concise, uniform definition for conditions caused by prenatal alcohol exposure. FASD is a broad term used to describe the range of effects that can occur in an individual whose mother drank alcohol during pregnancy (Caley, Kramer, & Robinson, 2005). Fetal alcohol spectrum disorder can also cause growth retardation, birth defectscomma and deficits in cognitive, languagecomma and motor development (Coles et al., 2015). Fetal alcohol spectrum disorder is a teratogenic effect, which is caused by daily, chronic, heavy and frequent alcohol use while in utero. Chances of an infant diagnosed with FASD are 0.5 to 3 in 1,000 live births (Cone-Wesson, 2005). Fetal alcohol spectrum disorder has many different diagnoses. There is fetal alcohol syndrome (FAS), partial fetal alcohol syndrome (PFAS)comma and alcohol-related neuro-developmental disorder (ARND)comma all under the fetal alcohol spectrum disorder umbrella (Brown et al., 2015). Maternal alcohol use is correlated to the timing, frequencycomma and quantity of the consumption of alcohol during pregnancy. Drinking during the first trimester may not be as detrimental as drinking during the second or third trimester. The frequency of alcohol consumed is also a key factor in FASD, such as how often per day drinks are consumed, the quantity of alcohol consumed, and how many glasses or cans per day the mother consumes

Alcoholism is a real threat to pregnant women. In particular, there is a huge rise in Fetal Alcohol Syndrome (FAS) cases, which is when an unborn fetus actually becomes addicted to and dependent on alcohol passed from the mother. In 1996, only 0.5 to 3.0 cases were confirmed for every 1,000 pregnancies, but today, that number is a staggering 20 to 50 cases per 1,000

According to Seaver, Fetal Alcohol Syndrome (FAS) is birth defects causing learning, and behavioral problems in individuals whose mothers drank alcohol during pregnancy. This disorder is very serious, yet it is recognized as one of the most preventable. This causes major issues, when something so serious could be prevented but is not. Fetal Alcohol Syndrome is a problem because it leaves a permanent effect on the unborn child, but some solutions could be educating women and putting up more informational posters and warning labels on products.

The term “Fetal Alcohol Spectrum disorders” (FASDS) is used to describe the numerous problems associated with exposure to alcohol before birth. Each year in the United States, up to 40,000 babies are born with “Fetal Alcohol Spectrum disorders” (FASDs) (Substance Abuse and Mental Health Services Administration). Additionally, Fetal Alcohol Spectrum disorders (FASDs) comes with effects that range from mild to severe. These effects include mental retardation; learning, emotional and behavioral problems; and defects involving the heart, face and other organs. According to the U.S. Surgeon General, the patterns of drinking that place a baby at greatest risk for FASDS are binge drinking and drinking seven or more drinks per week (Surgeon General). However, FASDS can occur in babies of women who drink less. There is no way of measuring how much alcohol one can consume before defects occur, and no proof that small amounts of alcohol are safe. As little as one drink a day can cause a baby some degree of harm and interfere with their normal development.

FAS is defined as a medical diagnosis involving four key features: alcohol exposure, growth deficiently, certain facial features, and brain damage. Infants who have been exposed to prenatal alcohol rarely show all symptoms of the medical condition FAS. Other terms have been used to describe the implication involved with FAS. Frequently used terms are: Partial Fetal Alcohol Syndrome, Alcohol-related Neurodevelopmental Disorder and Alcohol-related Birth Defects. A child with Partial Fetal Alcohol syndrome exhibits only some of the physical signs of FAS and will likely have both learning and behavioral difficulties. A child suffering from Alcohol-related Neurodevelopmental Disorder will demonstrate signs of neural damage, problems with memory, poor social skills, and learning difficulties. Children diagnosed with

As stated earlier, alcohol has its greatest effect on the developing embryo during the first trimester of pregnancy with its teratogenic effect causing mental retardation as well as characteristic craniofacial abnormalities that are characteristic of the disease. It has also been demonstrated with experimental animal models that there is a clear "dose-response" effect between the amount of alcohol consumed by the mother and the risk that is associated with developing FAS symptoms (Walpole, p. 875). It has been proposed by Walpole and associates that there are various degrees to which the fetus An be effected. Walpole uses the term "fetal alcohol syndrome" to refer to serious effects due to heavy maternal drinking and "fetal alcohol effect" to refer to those effects thought to occur with lower maternal alcohol intake (Walpole, p. 875). Regardless of the degree to which

Fetal Alcohol Syndrome (FAS) is a disorder that occurs when a mother consumes alcohol while pregnant. Individuals with FAS may face many problems such as, bad vision, hearing impairments, memory difficulty, communicative hurdles, and much more (Bergen & Yu, 2012). In began in 1981 when expecting mothers were advised not to drink while pregnant (Alcohol Policies Project, n.d). However, is 1995 4 times more mothers were consuming alcohol in comparison to a few years earlier in 1991 (Alcohol Policies Project, n.d). In addition, 52 percent of women ages 18-34 claimed to have been consuming alcohol while pregnant (Alcohol Policies Project, n.d). The reason for a mothers decision to drink is unknown, it could possibly be that mothers have read reports

Fetal Alcohol Syndrome (FAS) refers to a group of physical and mental birth defects resulting from a women’s drinking alcohol heavily or at crucial stages during pregnancy. Fetal Alcohol Syndrome was first named and treated in the late 1960's. This condition results from the toxic effect of alcohol and its chemical factors on the developing fetus. FAS is the leading cause of mental retardation occurring in 1 out of every 750 births. The frequency of FAS occurs about 1.9 times out of every 1000 births according to the latest figures, and minor effects can be seen in up to 20% of pregnancies per year. This number changes drastically for women who are clearly alcoholics. As high as 29 children out of every 1000 births will suffer from FAS

FAS or fetal alcohol syndrome is a severe form of fetal alcohol spectrum disorder (FASD), and the effects of this condition are usually permanent. There are a wide range of symptoms and these are just a few: a small head, smooth ridge between the upper lip and nose, small and wide-set eyes, very thin upper lip, or other abnormal facial features and below average height and weight. (The Healthline Editorial Team). 2015. Another factor that may affect the fetus and the baby in future development is stress. When you’re stressed, your body goes into "fight or flight" mode, sending out a burst of cortisol and other stress hormones. These are the same hormones that surge when you are in danger. They prepare you to run by sending a blast of fuel to your muscles and making your heart pump faster. (Watson, S). 2013. Some studies show that chronic stress may lead to low birth weight, and this is when you alter your bodies stress management system. And based on what I have read I do feel that lower stress levels outweigh the minor risks of controlled alcohol consumption. This is due to the fact that there have been no studies that directley link moderate alcohol consumption to birth defects. FAS has been linked to mothers who abused alcohol during

It can not be explained why one fetus with exposure to alcohol during pregnancy can be born with no disabilities while another with similar exposure can be born with fetal alcohol syndrome (FAS)

I. Description: Congestive Heart Failure is more of a syndrome than a disease. Heart failure may be classified according to the side of the heart affected, (left- or right-sided failure), or by the cardiac cycle involved, (systolic or diastolic dysfunction). (Schilling-McCann p. 176). The word "failure" refers to the heart's inability to pump enough blood to meet the body's metabolic needs. (Schilling-McCann p. 176). When the heart fails to deliver adequate blood supply edema may develop. (Cadwallader p. 1141). Where edema occurs depends on what side of the heart is failing.

Alcohol consumption among pregnant women is a growing problem not only in the U.S. but also to the rest of the world. Billions are spent treating birth defects and other symptoms related to prenatal alcohol drinking. Statistics done shows that treatment of the disorder costs the U.S. 6 billion dollars annually (Burd & Hardwood, 2004); adjust that to the current inflation rate and it could be as high as 8 million dollars. Fetal Alcohol Syndrome (FAS) Community Resource Center came up with $5.4 million dollars as the estimated expected lifetime costs for one child with FAS disorder in 2003. This includes direct cost

Another area of study is that if the mother has both or one of the alleles ADH1B*2 and ADH1B*3 her child is protected from FAS. ADH1B*2 and ADH1B*3 are polymorphisms of ADH1B which comes from the alcohol dehydrogenase (ADH), which is a catalyzing enzyme involved with the oxidation of ethanol. These alleles code for enzymes that cause oxidation of ethanol to occur at a much faster rate than usual. By having a faster oxidation rate alcohol will be metabolized and detoxified sooner. The alcohol consumed goes into your blood stream and is spread through the body, which could have a teratogenic effect on the foetus, until the alcohol has been completely metabolized. Therefore the faster the alcohol can be metabolized the less chance there is of it getting to the placenta and therefore into the foetus’ bloodstream. Due to the fact that the alcohol won’t be able to get to the foetus because it oxidised much quicker, the foetus is protected from the effects of the alcohol which lead to FAS.

The clinical features of both HFRS and HCPS are directly related to the pathophysiology of the hantaviruses, which preferentially infect the endothelial cells. Endothelial cells in the renal and pulmonary microvasculature are the principle targets in HFRS and HCPS, respectively. Damage to the microvasculature causes capillary leak, fluid extravasation and eventually organ failure. It has been suggested that immune mechanisms rather than direct viral cytopathic effects are responsible for the capillary leakage seen in both HFRS and HCPS. However, more recent evidence suggests that a virus-cell interaction, and an inhibiting interferon type 1 response may also play a role.