Pathophysiology, Signs And Symptoms, And Treatment Of Myasthenia Gravis

1726 Words Feb 23rd, 2016 7 Pages
Title of the Paper in Twelve Words or Less Myasthenia gravis (MG) is an autoimmune disease that affects nerve impulses to skeletal muscles. There are varying types of this disease and the symptoms can range from mild, a person having peripheral skeletal muscle weakness, to severe, a person having breathing problems (Sieb, 2014). Myasthenia gravis is diagnosed in 20 out of 100,000 people in the United States, and women are more likely than men to have the disease (Meriggioli and Sanders, 2012). This autoimmune disease can happen at any age, but women generally have an earlier onset than men; the mean age for females is 28 and 42 for males (Nair, Patil-Chhablani, Venkatramani, and Gandhi 2014). To better understand this disease this paper will explain the pathophysiology, signs and symptoms, and treatment of myasthenia gravis. In this autoimmune disease several factors affect transmission at the neuromuscular junction (NMJ), and in myasthenia gravis there are different sources that can cause problems at this site (Meriggioli and Sanders, 2009). Autoantibodies restrict normal functions of receptors and proteins and this disturbs synapse and conduction (Meriggioli and Sanders, 2009). Based on the type of receptor or protein affected certain treatments can be implemented towards the specific problem. Some sites that are disturbed by the antibodies are nicotine acetylcholine receptors (AChR), muscle specific tyrosine kinase (MuSK) or low-density lipoprotein receptor related…
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