Pemphigus Pathophysiology

5. What is the prevalence and prognosis of this condition? Is it an inheritable (genetic) condition/disease? (1 point)

This condition can be treated at anytime by an antibiotic like penicillin. Since this condition can damage the organs, it is better to get it treated sooner than later. It is also important to keep going back to the doctors to get blood work done repeatedly to make sure that the infection is totally cleared up.

While VGS is not usually highly pathogenic, it does tend to affect people who are already at risk from another health condition such as cancer or heart conditions. In order to become pathogenic, VGS must access the blood; once it does, it often goes to the heart and causes endocarditis (Doern). A common route of access is the oral cavity through bleeding gums or during dental procedures. This is why people with heart conditions take antibiotics before dental visits (Viridans-group). VGS is also the leading cause of dental caries and gingivitis (Viridans

It was important to discuss with Lisa during consultation family history that could provide additional support for my final diagnostic conclusion .Going thru such topic area Lisa explain that her husband James dad was suffering with atopic eczema since childhood .This was quite an important piece of information as such conditions like atopic eczema ( dermatitis ) are hereditary conditions often (National Eczema Society ,2011).Atopic dermatitis or eczema is a chronic skin disorder inflammatory with pruritic skin that appears mostly on the face ,neck ,bends of the arms or legs caused by the malfunction in the skin barrier( NICE,2013).

Any men at age 40 with a first-degree relative who had the disease at an early age should seek medical advice.

Humoral and cellular autoimmunity play a huge role in the appearance of vitiligo. Studies have found that are some major key things that play into this disease developing such as oxidative stress damage, autotoxicity, and neurohumoral

Psoriatic Arthirits affects an estimated thirty percent of individuals who suffer from psoriasis. Psoriasis is a autoimmune disorder that affects the cycle of the skin, causing inflammation and red lesions to form on the skin. Psoriatic arthritis causes joint and muscle pains, as well as swelling and damage of the joints and muscle, and typically causes tender spots where tendons and ligaments meet the bone. About fifty persont of patients diagoned with psoriasis or Psoriatic arthritic has a family background with the auto-immune disorder, suggesting it is a hereditary disease.

Outline the causes, incidence and risk factors of the identified condition and how it can impact on the patient and family

Atopic dermatitis (AD) is a pruritic disease of unknown origin that usually starts in early infancy; it is characterized by pruritus, eczematous lesions, xerosis, and lichenification. Atopic dermatitis may be associated with other atopic (immunoglobulin E [IgE]) diseases as asthma, allergic rhinitis, urticaria and acute allergic reactions to foods (Jansen et al., 1973).

Pemphigous gestationous is unlikely because this begins with blisters and is really an autoimmune disorder.

The first line of defense is formed by the stratum corneum, the uppermost layer of the epidermis. In the stratum corneum, filaggrin (FLG), a late epidermal differentiation protein, plays a pivotal role in the barrier function. It has been reported that loss of function variant of FLG gene leads to impaired skin barrier function and strong predisposing factor for atopic dermatitis (Palmer et al., 2006). FLG mutations may also increase the susceptibility to haptens, because mutations within the FLG gene were reported to represent a predisposition to contact allergy in both mice (Moniaga et al., 2010) and humans (de Jongh et al., 2008; Novak et al., 2008). On the other hand, other reports failed to find a clear association between contact allergy risk and FLG mutations (Lerbaek et al., 2007; Schnuch et al., 2010); therefore, further studies are needed to conclude the association between FLG mutation and contact dermatitis. Tight junctions are a second barrier to block antigen penetration into the skin. These junctions are composed of several proteins such as claudins and occludins in the stratum granulosum. Protein antigens are blocked from penetrating the body by this barrier. It has recently been reported that activated Langerhans cells (LCs) can elongate their dendrites above this barrier to take up protein antigens (Kubo et al., 2009), and the deficiency of LCs leads to reduced clinical

Psoriasis is a dermatological condition that is chronic and progressive. It affects almost all surface of the body. It is associated with excessive growth of skin on the affected areas like the nails, palms, soles, elbows, knees, trunk, abdomen and back. There is no cure available as on date, but there are measures and medications that can help to decrease the vigorous symptoms which affect the quality of life which makes the patient feel negative and depressed. It is not contagious, many a times due to ignorance psoriasis patients are isolated for fear of getting infected by the family members. The dramatic representation of an uncontrolled psoriasis really affects the social life and employment prospects of the patient feeling the patient

There are thousands of different genetic diseases that affect millions of people in our own nation and across the globe. Many of these diseases can be difficult to diagnose, having spectrums of different symptoms and characterizations, while some are relatively mild in their effects. One disease affecting around 50,000 people in the United States alone is called epidermolysis. This debilitating genetic disorder affects the epidermis, or skin, of those diagnosed. Although this disease was written about in the early 1800’s, we only found the specific gene affected in 1993. It’s time to shed some truth on a rarely discussed genetic disorder carrying many stereotypes and nicknames across the globe, epidermolysis.

Pemphigus Vulgaris (PV) is a severe chronic autoimmune vesiculobullous disease, characterized by the formation of auto-antibodies against epithelial glycoproteins, as desmoglein 1 and 3, leading to epithelial acantholysis. The disease may affect the epithelial tissues of skin and pharyngeal, laryngeal, esophageal, nasal, conjunctival, genital, and oral mucosae. The oral lesions present as superficial erosions and ulcerations distributed randomly at any site. However, palate, labial mucosa, the belly of the tongue and gingiva are the most affected sites. The incidence is rare under 50 years. This study reports a case of a young woman under immunotherapy for PV, referred by the dermatologist, due to a refractory gingivitis. Clinical examination

Psoriasis was copied from the Greek word psora, which means “to itch” (Jean, 2011). Psoriasis is a chronic, long lasting autoimmune skin disease that disturbs the speed of the growth cycle in skin cells (Stress-Related Disorder Sourcebook, 2016). Normal, healthy skin cells replace dead skin cells every twenty-eight to thirty days (Langley, 2005). Skin is the largest organ in the body. It protects from the environment, regulates body temperature, helps coordinate immune system regulation, function of touch sensations, waterproof, and prevents toxin substances from entering the body (Langley,2010). Psoriasis effects greater than three percent