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Prescription Medications for the Treatment of Obesity Essay

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An epidemic is sweeping through the developed world, threatening millions with disability and death. Is it the dreaded Ebola virus? No, it is obesity. ‘Epidemic’ may sound exaggerated, but the facts speak for themselves: 154 million people worldwide are obese—or more than 20% are over their ideal body weight—including more than 50% of all Americans. More disturbing is the prevalence of childhood obesity, which has jumped dramatically over the past 20 years and now accounts for a doubling in the incidence of diabetes, a 5-fold increase in sleep apnoea and a 3-fold increase in gall bladder disease. The World Health Organization and the US Surgeon General have already warned that obesity is a serious, life-threatening disease. Indeed, as a …show more content…

Indeed, research on fat metabolism has made large strides forward over the last decade and has challenged some established views. ‘One of the most important advances in obesity research is the realisation that fat is an endocrine tissue,’ said Barbara Kahn, Professor of Endocrinology at Harvard University’s School of Medicine. Another step forward was the discovery of a number of peptides that function as central regulators of food intake and energy homeostasis. These findings point to a complex involvement of the neuroendocrine system, where the central nervous system and fat interact through hormones and neurotransmitters, and affect other organs, most notably the liver and the pancreas.

Given the complexity of this system, it is no surprise that most treatments have been relatively ineffective or fraught with serious health risks, such as addiction to amphetamine diet pills, heart valve damage and hypertension. Furthermore, only a few drugs have reached the market recently. Xenical (Orlistat), a pancreatic lipase inhibitor developed by Hoffmann-LaRoche (Geneva, Switzerland), works by blocking the absorption of fat in the intestine, but can cause uncomfortable side-effects and has been linked to an increased incidence of cancer. Meridia (known as Reductil in the UK), originally developed by Knoll AG (Ludwidgshafen, Germany), is a serotonin and norepinephrine reuptake inhibitor that is thought to act on the appetite centre of the hypothalamus.

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