Research Paper On St. John's Wort

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During the last decade, St. John's wort (Hypericum perforatum) has gained popularity as an alternative treatment for depression and a natural remedy for reducing inflammation due to its especial chemical composition(1, 2). H. perforatum is a perennial herb of the Hypericaceae family native to parts of Europe and Asia (middle-east and other parts) and also has spread worldwide, including temperate regions of India, China, Africa, and some parts of the United States and is distinguished by its golden yellow calycles(1) . In addition, when flower buds are crushed, a reddish liquid would be exposed. This reddish liquid contains numerous compounds with biological activity such as phloroglucinols hyperforin, adhyperforin, the naphthodianthrones hypericin and pseudohypericin, the flavonoids hyperoside, quercetin, rutin, quercitrin and isoquercitrin, and the dimeric flavonoids amentoflavone(3). Oily Hypericum preparations have been used for centuries as a medicinal plant to treat burns, wounds, alcoholism, dermatitis, neuralgia and myalgia beside its antidepressant, antiviral, and antibacterial effects(4-7). Nowadays, …show more content…

perforatum herb which contains 0.2 mg/ml hypericin. Hypiran is recommended for a variety of ailments such as depression, insomnia, anxiety, headache, menstrual headache and migraine (22). With regard to anti-inflammatory benefits of H. perforatum, the aim of this study was to peruse the potential effects of Hypiran for the treatment and controlling inflammation in animal models of ulcerative colitis. 2. Material and methods: 2.1. Reagents Hypiran was purchased from Pursina Pharmacy (Tehran, Iran). Prednisolone was provided by Aburaihan Pharmaceutical Co. (Tehran, Iran). The enzyme-linked immunosorbent assay (ELISA) kits were procured from Qiagen (Hilden, Germany). Total protein assay kit was purchased from Zist chemi Co. (Tehran, Iran). Other reagents were obtained from Sigma-Aldrich (St. Louis,

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