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Ryr1 Week 2 Journal Analysis

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The halothane anaesthetic binded with the RyR1 receptor at the depolarization process where the RyR1 receptor released abnormally large amount of calcium, leading to continuous muscle contraction and the excessive production of heat. The affected ryanodine receptor of the skeletal muscle induces calcium exit from the sarcoplasmic reticulum of the skeletal muscle, consequently accelerating biochemical reactions which cause severe muscle contractions and elevates the metabolic rate, resulting in respiratory and metabolic acidosis. The binding of the anesthetic to the receptor overwhelms the body’s ability to supply oxygen. Uncontrolled calcium release triggered by the binding of halothane anaesthetic, causes excessive muscle contractions and

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