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Should Traditional Painkillers Be Safe Drugs?

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Introduction Dexmedetomidine (DEX), the newest sedative, is a highly selective α2-adrenergic receptor agonist having different mechanism from traditional agents (benzodiazepine [BDZ], propofol) which act on the GABA receptor. There are subtypes of α2-adrenergic receptor, which include α2A, α2B, α2C; DEX seems to produce its therapeutic effects primarily through the α2A receptor [1,2]. The sedative strategy for critically ill patients has emphasized light sedation with daily awakening and assessment for neurologic, cognitive, and respiratory functions, since SCCM guidelines were presented in 2002 and concerns on adverse effects associated with oversedation emerged [6-8]. However, traditional sedatives have some limitations as safe drugs for this strategy due to their unfavorable pharmacokinetic [9] or detrimental adverse effects that include lorazepam-associated propylene glycol intoxication [10] and propofol infusion syndrome [11]. Thus, there are growing interests on DEX as a possible alternative. After taking the approval of the local ethics committee, the patients were enrolled in a prospective, randomized, double-blinded study. Full explanation of the procedure, possible side effects and complications, were discussed before an informed written consent was obtained from the patients family. The current study was performed in Al-Azhar university hospitals. It was carried out on 40 patients, admitted to ICU and received mechanical ventilation , They were divided randomly

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