Sickle Cell Disease Is The Most Common Genetic Disorder

Sickle Cell Anemia is a genetic disease which can only be caused by both parents passing the sickle cell gene down to their offspring. About 2 million Americans carry the Sickle Cell gene but don’t have the disease. If two people with the gene marry, there’s a one in four chance that their children can end up having the disease. The gene is common with African, Spanish, Mediterranean, Middle Eastern, and Indian people. In the United States, Sickle Cell Anemia affects 1 in every 500 African American children born, and 1 in every 900 Hispanic children born.

People with sickle cell anemia have inherited two sickle cell genes, one from each parent. A child who has inherited the sickle cell gene from only one parent will not develop the disease, but will have sickle cell trait. People who have sickle cell trait don't have sickle cell anemia or symptoms of the disease, but they can pass the sickle cell gene to their own children.

The sickle cell disease affects about 100,000 people in the America. The most common ethnic group the sickle cell anemia is seen in is African Americans and Hispanics. Approximately one in every ten African American and one in every one hundred Hispanic Americans have the sickle cell trait. Approximately two million people have the sickle cell trait in America. Approximately one in five- hundred African Americans and one in one thousand to one thousand and four hundred Hispanic-Americans have sickle cell disease. No universal cure has been found for sickle cell anemia (“Facts About Sickle Cell Trait And Disease,”n.d.). Sickle cell anemia affects many Americans and a universal cure needs to be found.

Sickle cell anemia (SCA) is an inherited blood disease which causes normal, round, healthy red blood cells to transform into sickle-shaped cells. Normal red blood cells are flexible and can easily pass through capillaries to bring oxygen to different parts of the body. However, sickle cells are fragile, and can easily die, leading to anemia (red blood cell deficiency). SCA can also cause blood vessel occlusion (blockage of blood vessels), tissue infarctions (death due to lack of oxygen), bone, joint, and abdominal pain, yellow eyes and skin, pale skin, delayed growth, increased risk of infections, and damage to organs. The disease is passed on by autosomal recessive inheritance, which means both parents of a child must have the defective gene for the child to be affected. If only one gene is inherited, the victim becomes a carrier of the sickle cell trait, producing only some sickle cells with little or no symptoms. This means two people with the trait have a 25% chance of having a baby with sickle cell disease, 25% chance of them having no defects, and 50% chance of the baby becoming a carrier as well. When the gene is inherited, it mutates the beta (β) globin gene in chromosome 11, changing the hemoglobins produced using instructions from the gene from a healthy hemoglobin A (Hb A) to a mutated hemoglobin S (Hb S). Many tests can be done to check for sickle cell disease, the most common being an ordinary blood test, where the blood is examined for hemoglobin S. If the

Sickle Cell Disease or also widely known as Sickle Cell Anemia is a genetic mutation caused in red blood cells destroys its own cells within and reshaping the cell wall resembling crescent or sickle shape; getting its name of the sickle cell disease. These sickled shaped cells attempt to perform its normal function of circulating oxygenated and deoxygenated RBC and gets lodged in small vessels causing vaso-occlusion. Where vaso-occlusive take effect, rest of the body is not receiving oxygen becoming oxygen deprived results in acute and chronic pain and organ damage (Valerie Mann-Jiles, 2015). This disease a lifelong condition affecting not just the person carrying the disease but the whole family. Treating this disease

Sickle cell is a blood disease. People with sickle cell anemia have crescent moon shaped blood cells that are hard and sticky. When the Sickle cells move through blood tubes, they can clog blood flow and break apart. This can cause main, damage, and a low blood count. The symptoms of the disease are not life threatening, however are not enjoyable. Sickle cell anemia can cause you to experience dizziness, headaches, and shortness of breath. Your skin may also turn more yellow or pale than it usually is. Sickle cell is an inherited disease. It is an unpreventable disease that you are born with. If you have a sickle cell gene, you do not have sickle cell, however your children have a 25% chance of having sickle cell anemia. This blood disorder can cause pain and discomfort but it is unlikely that your life will be in danger if you have the disease.

Sickle Cell Anemia or Sickle Cell Disease (SCD) is a passed down blood disorder that attacks and destroys the red blood cells. This Disease was first discovered back in 1910. The disease was first described as a clinical entity by Herrick1 in 1910 (Anderson & Ware 1932). Sickle cell sickness is brought about by a change in the hemoglobin-Beta quality found on chromosome 11. Hemoglobin transports oxygen from the lungs to different parts of the body. Red platelets with typical (hemoglobin-An) are smooth and round and coast through veins. Typical red platelets are round like doughnuts, and they travel through little blood tubes in the body to convey oxygen. Sickle red platelets turn out to be hard, sticky and molded like sickles used to cut wheat. At times these blood cells can become crescent shaped and have a hard time passing through small blood vessels, this keeps red blood cells and the oxygen they carry from getting to all parts of the body. This causes less blood to reach the body at this point the tissues that have not received a normal blood flow will become damaged. Individuals who have sickle cell

(NHLBI, 2015) There are a few scenarios of the passing of the disease or trait from the parent to the offspring. If one parent has the gene it can be passed to the child, causing the child to be a carrier of the trait. In other words, the child will be able to produce normal hemoglobin as well as the sickle shaped hemoglobin. They will also be able to pass it to their offspring. If both parents carry the trait the child has a 50 percent chance of being a carrier, percent chance of not getting the gene at all, and 25 percent chance of having sickle cell anemia.

People with the sickle cell trait can never get the disease. They don’t have any of the symptoms except anemia which is usually treated with vitamins with extra iron.

The cause of sickle cell anemia is by a mutation gene. The gene tells your body to make hemoglobin. Hemoglobin is responsible for giving the blood its red color and allows the red blood cells to carry oxygen from your lungs to all the parts of your body. The sickle cell gene is passed down from one generation to the next and is inherited. It is called autosomal recessive inheritance. This happens when both the mother and father pass on the detective form of gene. If only one parent passes on the sickle cell gene to the child that means the child will have the sickle cell trait. People who have the sickle cell trait are carriers and can pass the defective gene to their children. Your ethnic background can put you at risk for sickle cell anemia.

Sickle cell anemia has been a huge or major controversy in the united states ever since 1973 until today. It is an inherited disease that affects the red blood cells.

The disorders for Sickle Cell Anemia is mutation, autosomal recessive, and blood loss. The chromosomes traveled from one parent to another which mean it's a positive chance the child will have that disease. Also that

This disease can cause severe pain and fevers, anemia, circulatory problems, strokes, and even “sudden death.” The sickle cells are able to get caught in the capillaries and disturbs the circulatory system (Eckman 447). When a person has abnormal swelling in their feet and hands, this could be caused by a buildup of “sickle-shaped red blood cells blocking blood flow to the feet and hands.” When sickle cells damage an organ, this can make a patient more “vulnerable” to infections (Mayo Clinic Staff). For example, when red blood cells “get stuck in the spleen,” this causes a splenic sequestration crisis. When this occurs, most of the blood cells are sent to the spleen which leads to less red blood cells being able to circulate in the blood stream. Symptoms of a splenic sequestration crisis include, “shortness of breath” and “having pale

The only way you get sickle cell is by inheritance from a family member, whether it be your mom or your dad. If a person inherits the sickle cell gene from only one parent will not develop the gene but will have something called sickle cell trait. People with sickle cell trait do not have the disease, but they might have a few sickle cell blood cells in their bodies. Although having sickle cell trait does not give them the disease they have the sickle cell gene and it will be passed down to their kids. Kids and parents may never know for a fact if they have the gene or not that is why doctors recommend getting checked out for sickle cell genes. To check for sickle cell genes doctors use a special blood test called a hemoglobin electrophoresis. All newborns get screened and tested for sickle disease. It is required in every state to have your newborn tested for sickle cell

Sickle cell disease, SCD, is an inherited autosomal recessive genetic disorder that affects 1 in 500 Americans of West African descent with one in 12 African Americans and one in 100 Hispanics being carriers (“Learning.” 2014). SCD is prevalent in individuals with origins in equatorial countries, such as central Africa, Near East, Mediterranean area, and in parts of India (McCance, 2010). Sickle cell anemia, sickle cell-thalassemia, and sickle cell-Hb C are all forms of sickle cell disease with sickle cell anemia being the most severe. Within the general population there is a 0.7% chance of two African American parents having a child with sickle cell anemia, a 1 in 800 birth risk for sickle cell-Hb C, and 1 in 1700 birth risk for sickle- cell thalassemia (2010). The incidence of sickle cell trait carriers can range from 7% to 13% in blacks and up to 45% in people from Eastern Africa. In comparison to the other forms of SCD, sickle cell anemia is present in a homozygous form. Individuals are considered to be sickle cell trait carriers when they inherit Hb S from one parent and normal hemoglobin from the other parent, these individuals rarely present with any clinical manifestations (2010).