Sickle Cell Disease Research Paper

Sickle Cell Disease is an illness that affects people all across the globe. This paper will give a description of the sickness through the discussion of the causes, symptoms, and possible cures. Sickle Cell Disease (SCD) is a "group of inherited red blood cell disorders."(1) These disorders can have various afflictions, such as pain, damage and a low blood count--Sickle Cell Anemia.

Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their red blood cells to change shape. Instead of being flexible and round, these cells are more rigid and curved in the shape of the farm tool known as a sickle - that's where the disease gets its name. The shape

This mutation paper is to give information on the Sickle Cell disease. This is a negative disease to have because the Sickle Cell Disease decreases the health of the person that has the disease and limits what they can and cannot do. Sickle Cell Disease is a red blood cell disease that causes ab normal hemoglobin to from in the veins. Hemoglobin is the protein that carries oxygen throughout the body to help with the respiratory system. The cause of the genetic mutation is inheritance or getting the disease from the parents the disease is found on chromosome 13 while the hemoglobin is still in beta phase on gene HB A. The disease typically shows symptoms within the first 5 to 6 months of birth and being diagnosed with Sickle Cell Disease. The symptoms include painful swelling on the hands and feet, and Jaundice, which causes a white color to form under the eyes, and turns the skin color yellow.

Complications of sickle cell anemia are pain crisis, infection, acute chest syndrome, splenic sequestration, vision loss, leg ulcers, stroke, deep vein thrombosis and pulmonary embolism. Pain crisis is a feeling of pain that can happen all of the sudden with mild to severe intensity and last for a period of time (“Facts About Sickle Cell Disease,” 2016). Serious bacterial infections are potential life threatening due to the damage to the spleen in some people who have sickle cell anemia (https://www.nhlbi.nih.gov/health/health-topics/topics/sca/signs). Acute chest syndrome can be life threatening and symptoms included chest pain, coughing, difficulty breathing, and fever. Splenic sequestration is can be life threatening

Sickle Cell Disease or also widely known as Sickle Cell Anemia is a genetic mutation caused in red blood cells destroys its own cells within and reshaping the cell wall resembling crescent or sickle shape; getting its name of the sickle cell disease. These sickled shaped cells attempt to perform its normal function of circulating oxygenated and deoxygenated RBC and gets lodged in small vessels causing vaso-occlusion. Where vaso-occlusive take effect, rest of the body is not receiving oxygen becoming oxygen deprived results in acute and chronic pain and organ damage (Valerie Mann-Jiles, 2015). This disease a lifelong condition affecting not just the person carrying the disease but the whole family. Treating this disease

So what exactly is Sickle Cell Anemia? Sickle cell is an inherited blood disorder that affects red blood cells due to the presence of an abnormal form of hemoglobin, namely hemoglobin S. Sickle cell has a lot to do with natural selection and is known as genetic disorder. You may never know who will have it in your family. It will not affect everybody. Sickle cell effect the red blood cells in your body. The red blood cells in your body begin to become deformed. They begin to look, “crescent shaped and have difficulty passing through small blood vessels, which could slow or block blood flow and oxygen to parts of the body.” The cresset shaped is where sickle cell gets its name from. When sickle cell mutates in your body, it begins to effect the muscles and even could possible effect the oxygen flow into your body. When the oxygen is blocked, this causes pain and even harm to your organs and even muscles. When this happen, this effects a person ability to be active. According to web MD, “Severe pain is an emergency called acute sickle cell crisis. A person may not know what brought on the pain, but infection and dehydration are common triggers.”

Sickle Cell Anemia is a horrifying, scary disease to have. Sickle cell anemia is a blood disease that is inherited. It comes from substitutions between a single amino acid and a component protein of hemoglobin. Globin, which is the component protein that has the substitution, isn’t effective. When someone has sickle cell, hemoglobin molecules with those component proteins, stick together and make strands of hemoglobin in red blood cells. Cells with that strand end up stiff and long, known as sickle shaped. Also, with sickle cell, those cells die faster than normal red blood cells and they aren’t easy to replace in a fast manner. Anemia within itself is when there is a huge shortage of red blood cells. When you think about the disease and

What is sickle cell anemia? Sickle cell anemia is a severe hereditary form of anemia in which a mutated forms of hemoglobin (a red protein responsible for transporting oxygen in the blood of vertebrates. Its molecule

Sickle cell anemia is a disorder that is caused by the abnormal shape of hemoglobin cells in the body. In lecture we learned that hemoglobin is the molecule that is present in red blood cells. Hemoglobin is responsible for supplying oxygen to other cells throughout the body. Red blood cells are normally rounded in shape, defected cells are in a long shafted shape, which gives the disease its name. When red blood cells sickle, they break down which causes anemia of the cells. Sickle cells can result in an individual having a low red blood cell count, having repeated infections, and suffering from long episodes of pain in different parts of the body. The disease can also cause delayed growth in children, shortness in breathe, fatigue, swollen feet and hands, and also vision problems.

The symptoms of Sickle Cell Disease is called sickle cell crisis, which is very painful event. The person affected by this starts to

Sickle beta thalassemia is an inherited condition that affects hemoglobin, the protein in red blood cells that carries oxygen to different parts of the body. It is a type of sickle cell disease. Affected people have a different change (mutation) in each copy of their HBB gene: one that causes red blood cells to form a "sickle" or crescent shape and a second that is associated with beta thalassemia, a blood disorder that reduces the production of hemoglobin. Depending on the beta thalassemia mutation, people may have no normal hemoglobin (called sickle beta zero thalassemia) or a reduced amount of normal hemoglobin (called sickle beta plus thalassemia). The presence of sickle-shaped red blood cells, which often breakdown prematurely and can

Sickle cell disease (SCD) is a hereditary blood disorder that occurs due to an abnormality in the oxygen-carrying protein hemoglobin found in red blood cells which causes the sickle hemoglobin (HbS) to polymerize and form a sickle or a crescent shape instead of the circular shape of healthy red blood cells (Sickle Cell Disease, George). Ribosomes are responsible for the creation of protein in the body, meaning it is most likely that the ribosomes malfunctioned in the creating of the hemoglobin. A lack of healthy blood cells can lead to lack of oxygen and decreased blood flow throughout the body (Sickle cell anemia, mayoclinic.org). This can cause many different

Sickle cell disease was discovered in 1910 in the United States. Many cases came to surface after that, and it was clear that sickle cell disease is predominantly common in the African American ethnicity. Sickle cell disease is caused by a mutation in the hemoglobin of red blood cells. The most common, known sickle cell disease is sickle cell anemia. There is no cure for Sickle cell disease, but there was a treatment that help relieve pain, prevent infections, and prevent organ damage. A drug called Hydroxyurea could be used to increase the production of fetal hemoglobin during pregnancy. Bone marrow treatment, is when stem cells are removed from one person to another person. Cord blood with stem cell transplantation, can replace someone’s abnormal stem cells with a donors stem cell.

Sickle Cell disease (SCD) is an inherited blood disorder in which abnormal hemoglobin is produced in red blood cells. The body creates sickle red blood cells, which are crescent shaped instead of the typical round shape. This shape of the sickle cells are stiff, as well as stick and because of this they tend to block blood flow in the blood vessels of the limbs and organs. This blockage will cause pain and organ damage, as well as serious infection. (National Heart, Lung, and Blood Institute [NHLBI], 2014.). Sickle Cell Disease is also known as sickle cell anemia and Hemoglobin SS Disease.

Sickle-cell disease majorly affects the hemoglobin that is present in our blood. The job of hemoglobin is to help transport oxygen and carbon dioxide to and from the cells throughout our body. Hemoglobin is present specifically in our red blood cells. Each red blood cell contains two hundred and eighty million hemoglobin molecules. Red blood cells normal shape is a biconcave shape because of the lack of many organelles and a nucleus. The shape is so important to a red blood cells functioning that if it is not shaped normally it has major consequences. The shape helps them to fit through capillaries easier and also allows for an increased surface area which results in easier gas exchange. Sickle-cell disease is a genetic disease that causes issues in the oxygen/carbon dioxide carrying hemoglobin molecules that are present in our red blood cells.