Simovastatin Essay

High cholesterol level is a condition in which the concentration of high density lipids (HDL) specifically cholesterol, has significantly increased in the blood. The build up of these lipids in arteries reduce the supply of blood and hence, oxygen to the heart. Consequently, high cholesterol can lead to stroke or heart attack. Apo – Atorvastatin (Atorvastatin Calcium Tablets) is a medication that helps lower the concentration of cholesterol and other HDL in the blood (Apo-Atorvastatin, 2011) and is manufactured by Apotex Inc.

Of the three components likely to be present in your sample of Panacetin (aspirin, acetanilide, and starch), only starch is insoluble in the organic solvent dichloromethane (or methylene chloride), CH2 Cl2. If a sample of Panacetin is dissolved as completely as possible in dichloromethane, the insoluble starch can be filtered out, leaving acetanilide and aspirin in solution. The purpose of this experiment is to extract the components of Panacetin.

During World War II , Hodgkin and her student Barbara Low developed the structure of penicillin, from some of the first crystals ever made of the vital new drug. In 1948, Hodgkin began work on the structure of vitamin B-12 and it’s relationship with anemia. She obtained crystals of the material from Dr. Lester Smith of the Glaxo drug company, and worked with a graduate student, Jenny Glusker, an American team of crystallographers led by Kenneth Trueblood, and later with John White of Princeton University. Trueblood had access to state of the art computer equipment at the University of California at Los Angeles, and they sent results back and forth by mail and telegraph. Hodgkin and White were theoretically affiliated with competing pharmaceutical

Probably the most ironic things of all is that means again in 1985 researchers learned a fail proof method to scale down ldl cholesterol with out the usage of any pharmaceutical medications. Actually, statins most effective appeared on the scene a brief even as later, and as is to be anticipated, they became the principal form of healing for top cholesterol. The common therapy i'm relating to is none instead of ascorbic acid.

J.J. explained her atorvastatin calcium medication is used for treating her high cholesterol. Atorvastatin calcium is an HMG-CoA reductase inhibitor, therefore meaning it lower lipids (fats) in the body (MedlinePlus, 2018). Atorvastatin calcium works by lowering high cholesterol levels (MedlinePlus, 2018). Atorvastatin calcium

Many forms of statins are present in the markets including atorvastatin (Lipitor), lovastatin (Mevacor, Altocor) and simvastatin (Zocor). Inhibition of 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG-CoA reductase), a key enzyme in the cholesterol biosynthetic pathway is the mode of action of most of the statins (2).

The Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (EPDETHBCA) (2001), made the low density lipoprotein (LDL) their primary target of therapy, which is the major cholesterol carrying lipoprotein particle in plasma, is primarily derived from lipoprotein particles made by the liver, as the levels of LDL cholesterol increase, the risk of developing CVD increases. An estimated of 13.8% of adults have total serum cholesterol levels ≥240 mg/dL (Go et al., 2014). Saturated fatty acid and trans fatty acid intakes tend to increase LDL, which are the strongest dietary causes of elevated LDL concentrations (Lichtenstein, Ausman, Jalbert & Schaefer, 1999). The increase LDL cholesterol and reduce high density lipoprotein (HDL) cholesterol, cause endothelial damages which is the first stage in the development of atherosclerosis and may cause thrombosis afterwards (Thomas et al., 2007). Inflammation under lies atherosclerosis can be influenced positively by anti-inflammatory diet (Thomas et al., 2007). Independent of

Fluvastatin is a highly regarded drug that is involved with treating hypercholesterolemia and preventing cardiovascular disease. The drug is used to lower both high cholesterol and triglycerides levels. The drug is able to perform this task by increasing good cholesterol levels (HDL) while, at the same time, reducing bad cholesterol levels (LDL). Fluvastatin decreases the production of bad cholesterol by blocking the action of the enzyme HMG- CoA reductase in the liver. This results in a decrease in the amount of cholesterol in liver cells and subsequently leads it

Zocor is the brand name of simvastatin, developed by an American company called Merck & Co. Originally, the research was done by a biochemist named Akira Endo in the Sankyo Company. This drug is now used to treat various lipid disorders and patients at high risk for Coronary Heart Disease (CHD).

Statins (also known as 3-hydroxy-3-methylgutaryl coenzyme A reductase inhibitors) are widely prescribed cholesterol-lowering drugs for the treatment of dyslipidemia and cardiovascular disease. Although they are considered to be drugs with a very good safety profile, there are many concerns that their adverse effects might compromise their proven beneficial effects due to their extensive usage.

Statin pills, including Lipitor, which can be prescribed to decrease cholesterol levels, paintings partly through interfering with the activity of HMG-CoA reductase. If your cells take place to want more LDL cholesterol below certain circumstances, but the statin drug is blockading this essential enzyme, your cells won 't be able to make cholesterol whilst wished.

Joseph is a 39-year-old male who suffers from pure hypercholesterolemia (E78.0), along with hypertension, mild cardiomyopathy, non-sustained ventricular tachycardia and abnormal liver function. His most recent lab reports his cholesterol at 248, triglycerides 150, HDL 48, LDL 170. Joseph has tried and failed various treatments including liptor and zetia, with his cholesterol levels being sub-optimally controlled. Your reason for denial was due to his diagnosis. Repatha is not a statin, but works differently as a PCSK9 inhibitor that targets a protein in the liver called proprotein convertase subtilisin kexin 9, or PCSK9. By reducing the amount of PCSK9 in the body, PCSK9 inhibitors allows the body to remove cholesterol more efficiently.

It decreases the activity of \textit{3-hydroxy-3-methylglutaryl coenzyme A reductase}(HMGCR), an enzyme involved in one of the first steps in creating cholesterol\citep{pmid15803163}. It enters hepatocytes through the SLCO1B1 transporter, after which it is metabolized to its active form\citep{pmid22992668}. SLCOB1 transports many endogenous and xenobiotic substrates. Many statins (and other substrates) are too hydrophilic to enter the cell through passive membrane transport, thus need to be transported actively through SLCO family

Boehringer Ingelheim (BI) and Eli Lilly, manufacturers of empagliflozin (Jardiance) and empagliflozin/metformin (Synjardy)were the primary sources of funding for the study

Lovastatin, a natural product drug, is a cholesterol-lowering agent isolated from a strain of Aspergillus terreus. It is an oral antilipemic agent produced by fermentation of fungus. This drug is highly lipophilic and belongs to the class of medications called statins.1 Statins, also known as HMG-CoA reductase inhibitors, are a class of drugs that lower the level of cholesterol in the blood by reducing the production of cholesterol by the liver. Statins block the enzyme hydroxy-3-methyl-glutaryl coenzyme A reductase(HMG-CoA) in the liver that is responsible for making cholesterol. Lovastatin is a prodrug which lowers the cholesterol level through reversible competitive inhibition of HMG-CoA.2 By lowering high cholesterol in people with hypercholesterolemia,