Study of the Mobility and Fall Risks of Elderly Subject and Vitamin D Intake

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GOALS AND SUMMARY

The goal of the study was to evaluate and analyze the mobility and fall risks of the elderly subjects. Precisely, the main objective of the study was to evaluate the decremental effects of aging on a novel index of mobility, i.e., dynamic stability, and fall risk in an elderly population, and to test for correlation of vitamin D levels with fall risk and mobility-related outcomes (i.e., dynamic stability, strength, gait parameters, and physical activity).

Mortalities from fall accidents are steadily on the rise for the elderly. In this study, the cause of the fall risk will be inferred by analyzing the relationship between Vitamin D statuses (deficiency) and how it relates to mobility and fall risk related outcomes
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In most subjects, sun exposure is the primary determinant of vitamin D status, accounting for 80-90% of the vitamin D body stores. Cholecalciferol (vitamin D3) is synthesized in the skin and found in fatty fish and mammals, whereas ergocalciferol (vitamin D2) comes from yeasts and plants. Vitamin D supplements may contain either vitamin D2 or D3. Previously, the two vitamin D metabolites were considered to have an equal potency, but recent studies have suggested that vitamin D2 may be inferior to vitamin D3 in the treatment of vitamin D insufficiency [Romagnoli et al. 2008].

Moreover, there are few studies on the effects of vitamin D supplementation on muscle strength and mobility in older people with low vitamin D status, although a recent study has suggested benefit on mediolateral sway in participants who had large sway at baseline. Recent investigations have posited a direct link between vitamin D and skeletal muscle, with a deficiency correlating with muscle atrophy, decreased strength, functionality, and greater prevalence of falls and fractures. Moreover, this deficiency is increasingly recognized as a worldwide epidemic [Cando et al. 2011; Holick 2007] [Girgis et al. 2012] with more than a billion people worldwide deficient in vitamin D [Jannsen 2009].

Apropos to our investigation, only a few studies have objectively measured muscle strength longitudinally in relation to vitamin D status (i.e., serum 25(OH)D levels) in elderly individuals [Jannsenn et

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