1. The physical consequences of thiamine deficiency in chronic alcohol use include peripheral neuropathy, characterized by peripheral nerve damage, which results in pain, burning, tingling, or prickly sensations of the extremities. 2. Tolerance develops when the amount required to achieve the desired effect continues to increase. 3. Specific symptoms of PCP intoxication are dose related and may be manifested by impulsiveness, impaired judgement, assaultiveness, and belligerence, or the individual may appear calm, stuporous, or comatose. Furthermore, symptoms of Ecstasy include: increased heart rate, blood pressure, and body temperature; dehydration; confusion; insomnia; and paranoia. 4. Substitution therapy is the use of various medications
Alcohol is causing the brains of these children to be poisoned, as it is a neurotoxin. The excessive consumption of alcohol can interfere with the absorption of vitamin B, which helps prevent the brain from being able to function correctly. Drinking above the recommended levels can cause brain disorders later on in life. Some symptoms of these disorders include: difficulties learning and problems memorizing things, and difficulties with balance.
The pathophysiology of alcoholism begins after alcohol the ingestion of alcohol. It is absorbed and unaltered through the stomach and intestines. Next it is distributed throughout the body through the blood and absorbed by all tissues and fluids (Huether, 2012, p. 72). Furthermore, in the liver the alcohol blood content is metabolized into acetaldehyde by the enzymes process of alcohol dehydrogenase (ADH), the microsomal ethanol oxidizing system (MEOS), and catalase (Huether & McCance, 2012). Next, the metabolizing effects the central nervous system (CNS) and exhibits a depressant action. It is first expressed in the subcortical structures of the brain. This has an effect of disorientation of motor skills and intellect. With an increase in blood alcohol concentration, the medullary centers become depressed and as a result affects respiration (Huether & McCance, 2012). In addition, the effects of alcoholism encourage hepatic and gastric changes. The hepatic effect is caused by acetaldehyde, in which, induces inflammation, fatty deposits and enlargement of the liver (Huether & McCance, 2012).
4) The general effects of alcohol on the brain are blurred vision, weakened motor skills, blurred vision, slurred speech, slowed reaction times and impaired memory. In the liver alcohol causes fat deposits to develop in the liver and cause inflammation even eventually liver disease. Similarly, in the pancreas prolonged use can cause inflammation which yields vomiting, fever, weight loss, and is potentially fatal. Lastly, in the kidneys alcohol can increase the risk of high blood pressure developing in chronic kidney disease.
PCP is a Schedule II substance in the United States, meaning that the drug or other substances have a high potential for abuse, the drug or other substances have currently accepted medical use in treatment in the United States, or currently accepted medical use with severe restrictions, and abuse of the drug or other substances may lead to severe psychological or physical dependence. PCP’s manufacturing quota for 2014 was 19 grams. It’s mostly young people who abuse this drug. In 2008, more than 37,000 people needed to be cared for in hospital emergency rooms as a result of PCP abuse. About one percent of high school students reported using this drug in the years 2007-2009. It is known that PCP residues store in the fatty tissues of the body, where it can be dislodged later and create flashbacks in a similar way that LSD can cause flashbacks. There many street name for PCP some include: Angel Dust, Amoeba, Zoom, Super Grass, PeaCe Pills, Animal Trank, and Peter Pan. PCP mixed with marijuana street names are: Wet, Dust Blunt, Love Boat, and Happy Sticks. PCP mixed with MDMA (ecstasy) street names are: Pikachu and Elephant
The pathophysiology of Alcohol affects virtually every organ system in the body. Therefore, consuming to much alcohol in high
The resulting high dopamine levels are responsible for the hallucination, dissociation and psychosis within reactions to PCP.
Numbness of the extremities, slurred speech, and loss of coordination may be accompanied by a sense of strength and invulnerability. A blank stare, rapid and involuntary eye movements, and an exaggerated gait are among the more observable effects. Auditory hallucinations, image distortion, severe mood disorders, and amnesia may also occur. In some users, PCP may cause acute anxiety and a feeling of impending doom; in others, paranoia and violent hostility, and in some, it may produce a psychosis indistinguishable from schizophrenia. Many believe PCP to be one of the most dangerous drugs of abuse.Physiological effects of PCP include a slight increase in breathing rate and a more pronounced rise in blood pressure and pulse rate. Respiration becomes shallow, and flushing and profuse sweating.At high doses of PCP, there is a drop in blood pressure, pulse rate, and respiration. This may be accompanied by nausea, vomiting, blurred vision, flicking up and down of the eyes, drooling, loss of balance, and dizziness. High doses of PCP can also cause seizures, coma, and death (though death more often results from accidental injury or suicide during PCP intoxication). Psychological effects at high doses include illusions
This means that every time a person goes to take more PCP, they have to start taking a higher dose to get the same high effect as before. Most hallucinogens are not addictive, PCP however is majorly addictive. PCP dependence is shown by the withdrawal symptoms, such as extreme depression and psychosis. Treatment for addiction is antidepressants and counseling through an inpatient facility. The correct treatment is needed for PCP users because withdrawal symptoms could be so severe that it could lead to seizures. An inpatient program is also necessary because of relapse. Some of the top reasons for relapse is stress, negative emotions, and people or places associated with the negative behavior, therefore it is crucial to have a support system such as a
Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, slurred speech, tremors, a slow heartbeat, shallow breathing, feeling light-headed, fainting, seizure (black-out or
Miller. N.S, Gold. M.S,(1991). “Neurological Effects of Alcohol”. Alcohol Plenum Medical Book Co., New York, 35-45.
The short term effects are broken down into two categories: low-moderate doses, and high doses. In low doses of PCP, users report various symptoms.There are changes in body awareness, shallow breathing, flushing, profuse sweating, generalized numbness, and poor muscular coordination. In high doses of PCP, severe side effects accompany the drug. It causes hallucinations, seizures, coma, and even death(normally self inflicted or accidents that occur while intoxicated). Another side effect
The effects associated with alcohol are produced by the ethanol in the alcohol. The severity of these effects is reflected by the concentration of alcohol in an individual’s blood, which is dictated by the amount of alcohol ingested, the volume of blood, the individual’s metabolism, and amount of time since ingestion. In large doses, alcohol acts as a depressant of the central nervous-system. A blood alcohol level of 0.1% affects some of the motor areas of the brain associated with speech, balance and manual dexterity. A blood alcohol level of 0.2% depresses all motor functions and the area concerned with emotions is depressed. At a blood alcohol level of 0.45% the entire section of the brain that handles perception is depressed and the individual becomes comatose. At a blood alcohol level of 0.7% the parts of the brain that control the heartbeat and breathing are depressed and the individual
In Jill Dombrauckas’s (2015) report, she discussed that the Pennsylvania DUI Association made a large amount of researches about alcohol’s effect on body systems. In one research, alcohol affects the central nervous system which means when the individual drink alcohol, the messages that are carried to and from the brain and the body’s muscles can be slowed delivery. For example, the incoming signals from the brain, like the painful sensory that will decrease the injury’s awareness. Also the signals from the brain to the muscles will lead the motor skills becoming insensitive.
Alcohol has no beneficial attributes on a person’s health. Alcohol can have several harmful effects on human organs. Some organs in the human body that are damaged by alcohol consumption are the brain, kidneys, and liver. The human liver is the one organ that suffers the most damage. As stated in an article published by the National Institute on Alcohol Abuse and Alcoholism, “Because the liver is the chief organ responsible for metabolizing alcohol, it is especially vulnerable to alcohol – related injury” (NIAAA, 2005). Regular use of alcohol can lead to alcoholic liver disease (ALD). The severity of ALD can vary based on several different factors. Some of these factors include gender, age, the amount consumed, and how often alcohol is used. “ALD includes three conditions: fatty liver, alcoholic hepatitis and cirrhosis” (Alcohol Alert, 2005).
"Many alcoholics exhibit swollen and tender livers. The prolonged use of large amounts of alcoholism without adequate diet may cause serious liver damage, such as