The Cause And Effects Of Antibiotic Resistance And Antibiotics

The development of antibiotics was an important advancement in 20th century medicine. Previously deadly infectious diseases are now routinely treated with antibiotics. Moreover, for modern-day medical procedures such as chemotherapy treatment to be successful, antibiotic use is necessary. For these reasons, the prospect of bacteria developing widespread resistance to antibiotics is a major concern as it would render many modern-day medical therapies unviable.

Antibiotics are inarguably one of the greatest advances in medical science of the past century. Although the first natural antibiotic Penicillin was not discovered until 1928 by Scottish biologist Alexander Flemming, evidence exists that certain plant and mold growths were used to treat infections in ancient Egypt, ancient India, and classical Greece (Forrest, 1982). In our modern world with the advent of synthetic chemistry synthetic antibiotics like Erithromycin and its derivative Azithromycin have been developed. Antibiotics have many uses including the treatment of bacterial and protozoan infection, in surgical operations and prophylactically to prevent the development of an infection. Through these applications, antibiotics have saved countless lives across the world and radically altered the field of medicine. Though a wonderful and potentially lifesaving tool, antibiotic use is not without its disadvantages. Mankind has perhaps been too lax in regulation and too liberal in application of antibiotics and growing antibiotic resistance is the price we must now pay. A recent study showed that perhaps 70% of bacterial infections acquired during hospital visits in the United States are resistant to at least one class of antibiotic (Leeb, 2004). Bacteria are not helpless and their genetic capabilities have allowed them to take advantage of society’s overuse of antibiotics, allowing them to develop

Antibiotic use in animals has recently captured the attention of various professionals as the blatant, adverse effects have become increasingly prevalent. Agricultural manufacturers carelessly inject livestock with antibiotics in order to maximize their weight gain by minimizing the amount of energy consumed in fighting illnesses. This broad use of antibiotics in food-producing animals has contributed to the emergence and distribution of antibiotic-resistant bacteria, resulting in either mild or fatal illnesses. To put the severity of this issue in perspective, legislators must realize that 1 in 5 antibiotic-resistant infections are caused by bacteria from food and animals. Although antibiotic use in animals is not the sole culprit of the

Antibiotic resistance is when microorganisms, such as bacteria, are able to survive an exposure to antibiotics and these bacteria are now resistant to the effects of these antibiotics. Antibiotic resistance in bacteria has been an issue since antibiotics were discovered. The fact that bacteria can become resistant to our medical treatments such as antibiotics is a natural evolutionary process, but there are certain human contributions that definitely speed up the process. For example, one of the main contributions that will be discussed is the problem of over prescription of the antibiotic drugs. The

The misuse of penicillin and other antibiotics however is causing the growing problem of antibiotic resistance in which seemingly harmless infections turn to be deadly and dangerous. Antibiotics are not only casually used as treatments for bacterial infections, but are also used in agriculture and veterinary medicine, creating controversy on the proper uses of antibiotics. As advancements in the medical fields proved to be beneficial for a short period of time, today the misuse of these innovations are creating more and more problems that have proven to be dangerous to the accustomed health of the global population. Antibiotics were not always considered to be a superficial medication and, in fact, have been naturally used for millions of years, like with ants and their symbiosis with antibiotic producing fungi. Humans do not fully realize the value that antibiotics have brought to the population and do not take measures to preserve their use. In contrast, humans take for advantage the natural benefits that is given to them to overly benefit themselves, such as while creating revenue through mass production despite warning from scientists. This selfish misuse leads to consequences in which the future will have to provide solutions for, and perhaps even follow in the ants’ footsteps.

Antibiotics have played an essential role in the fight against diseases and infections since the 1940’s. Antibiotics are a leading cause for the rise of global average life expectancy in the 20th and 21st century. They have greatly reduced illnesses and deaths due to diseases. With the introductions of antibiotics in the 1940’s, like penicillin into clinical practice, formally deadly illnesses became immediately curable and saved thousands of lives (Yim 2006). Antibiotic use has been beneficial and when prescribed and taken correctly their effects on patients are exceedingly valuable. However, because these drugs have been used so widely and for such a long period of time the bacteria that the antibiotics are designed to kill have adapted,

A current predicament in the field of science is antibiotic resistance against superbugs.Though fighting against superbugs; which can be defined as a strain of bacteria unable to be killed using multiple antibiotics, is now a large problem, in the past it was not. The evolution of resistance in bacteria due to antibiotic abuse and lack of product development has brought upon us once again the fear of a pre-antibiotic era; one where simple, once easily defeated infections could kill. Already, infectious diseases are the 3rd leading cause of death in the US and the 2nd across the entire world, and drug resistant superbugs send 2 million Americans to hospitals every year; killing 23,000 of those people. And any bacterium can quickly and easily become multidrug resistant, the leading cause of this being antibiotic misuse in both humans and animals.( "Clinical Infectious Diseases." The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America. UCLA Medical School. Web. 27 Mar. 2016.)

Widespread use of antibiotics has been very controversial in the media as well in the general population. Due to these controversies, it is very misunderstood to how antibiotics work leading to many patients in the hospital setting wanting to take them when it is not necessary or refusing to take when it is necessary for their survival. Some of this controversy is due to antibiotic resistance, which has spread an alarming rate in the 21st century (Walsh, 2000). Antibiotic resistance is the result of very strong bacteria or microbes that are resistant to the antibiotic prescribed and those microbes accumulate overtime by their survival, reproduction and transfer, leading to increased levels of antibiotic resistance.

The general populace of western civilization may believe that modern medicine is limitless and that numerous afflictions that are common can be easily resolved with the major strides medicine has taken in the past century. In the case of antibiotics, this couldn’t be farther from the truth and its use leaves a nasty prospect for the future. Antibiotics, the type of drug that is capable of killing harmful bacteria, is widely regarded as a simple gift from medical research and is expected to be prescribed for even the mildest of illnesses. However, the use of antibiotics has proved that it comes with a terrible byproduct: leftover bacteria that survives the drug and evolves strains that are resistant to the drugs the world currently

(KArch) We as human-hosts are not just helpless victims, our continuous reliance on antibiotics treatment helps contribute to the ever growing problem. The increased and inappropriate use of antibiotic therapy is the main cause of these antibiotic resistant bacteria. Patient this day and age are often prescribed pills for every condition. Patients come into doctors’ offices demanding antibiotics and healthcare providers are filling these orders. This in turn contributed to this growing chain of antimicrobial resistance.

Dr. Martin Blaser, author of Missing Microbes: How the Overuse of Antibiotics is Fueling Our Modern Plagues, paints antibiotics as a negative force in the world that causes disease. Dr. Blaser has studied the role of bacteria in human disease for more than thirty years at Vanderbilt University, and has experience as the director of the Human Microbiome Project at New York University. He also works with the National Institute of Health on infectious diseases. Meanwhile, Dr. David Shlaes, author of Antibiotics: The Perfect Storm, focuses on the drugs’ ability to cure disease. Dr. Shlaes has worked for 30 years in anti-infective academia, industry, and consulting. He served as Professor of Medicine at Case Western Reserve University for five years, and then moved to industry, where he became vice president of Infectious Diseases at Wyeth Research. Later, he took a position as executive vice president of research and development at Idenix Pharmaceuticals in Cambridge, Massachusetts, and formed his own consulting company. He now works predominantly with biotech companies and venture capital firms in their evaluation of anti-infective companies. While they take different approaches, the two doctors concur that antibiotic resistance is a major problem and that society needs to find ways to slow it down. One way to slow down the spread of resistant bacteria is finding ways to ensure

Overtime, antibiotics have been favorable as well as negligent to society. Antibiotic usage is helpful to society because it kills and fights off bacteria in both humans and animals. With an increase in antibiotic usage, these bacteria have become resistant to certain drugs which reduce the chance of the bacteria being killed off and result in bacteria multiplying, causing increased harm to the infected. According to Centers for Disease Control and Prevention (CDC, 2013), each year in the United States at least 2 million people become infected with bacteria that are resistant to antibiotics and at least 23,000 people die each year as a result to these infections. Although multiple bacteria are antibiotic resistant, and those numbers will continue to rise, antibiotics should remain a staple in the treatment of diseases, as opposed to abandoning their use which will cause an increase in the prevalence of bacterial infections.

Antibiotic-resistant microbes infect more than two million Americans and kill over 100,000 each year. These numbers will continue to grow unless we make a drastic effort to curtail them. The necessary response is threefold and includes legislation, awareness, and activism. I will address all of these.

The overuse of antibiotics has been a problem for well over a decade. This misuse leads to many nonvisible problems arising within the human population. As the use of antibiotics increases, the number of antibiotic resistant bacteria also increases. When bacteria become resistant to an antibiotic, another antibiotic must be used to try and kill it and the cycle becomes vicious. Michael Martin, Sapna Thottathil, and Thomas Newman stated that antimicrobial resistance is, “an increasingly serious threat to global public health that requires action across all government sectors and society” (2409).

According the World Health Organization (WHO), antibiotic resistance is one of the world’s greatest health threats to date (Haddox, 2013). In the article, The Health Threat of Antibiotic Resistance, Gail Haddox (2013) discusses the danger antibiotic resistance poses in today’s society and strategies to prevent the expansion of antibiotic resistance. In Europe alone, an estimated 25,000 deaths have been attributed to multi-resistant infections (Haddox, 2013). Common infections are now harder to treat due to the increased resistance to antibiotics across the world, in fact some are becoming untreatable. Antibiotics should be treated like oil, a non-renewable resource (Haddox, 2013).