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The Cerebral Cortex

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Q1: The cerebral cortex is a highly organized, six layered structure (L1-6) with a variety of excitatory and inhibitory cell types. Excitatory (glutamatergic) neurons make up 80% of the cortex and consist of pyramidal and spiny stellate (granule) neurons. Inhibitory (GABAergic) neurons make up only 20% of the cortex and consist of four different subtypes: non-fast spiking serotonin expressing GABAergic neurons, martinotti cells, basket cells, and chandelier cells (Petersen & Crochet, 2013; Shipp, 2007). The total number of neuronal cells in the adult human cortex is 21.4 billion for females and 26.3 billion for males; however, there are also non-neuronal cells present in the cortex (Pelvig, Pakkenberg, Stark, & Pakkenberg, 2008). The major non-neuronal cells are glial cells and consist of: oligodendrocytes (75% of non-neuronal cells), astrocytes (20%) and microglia (5%) (Pelvig et al., 2008). The layering of the cortex is highly organized, with specific cell bodies located in each layer. Layer 1 receives input from other cortical layers as well as subcortical layers and is comprised solely of inhibitory neurons, although there are axons and dendrites that project onto these neurons in addition to non-neuronal cells (Petersen & Crochet, 2013). Layers 2/3 are difficult to differentiate from one another, and often referred to as the supragranular layers. These layers contain medium sized pyramidal cells that have densely packed and highly aligned apical dendrites and make

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