The Effect Of Metal Chelation On Latin

1553 Words Nov 15th, 2015 7 Pages
Introduction
Chelate means claw in Latin. Metal Chelation is a process when a polyvalent metal ion form covalent bonds with a drug and binds tightly to form a 5 or 6 membered ring. 5 and 6 membered ring structure are very stable because their bond angle has no ring strain. Thus, when a compound is chelated, it will not be able to pass through the biological membrane, in another words, it will not be metabolise by the body but to be pass through the renal without being absorbed and being excreted though urine. Essential metal such as magnesium, iron, calcium and zinc are easily found in many food source and is vital to be included as part of our diet as these trace elements are helping our body enzymes, hormones and cells to work. Insufficient intake of trace minerals can cause symptoms of nutritional deficiency. (Glusker,1999) At certain times, these metal are also use as an active ingredient or excipients in pharmaceutical industry.
Chelation of Alendroic Acid with Calcium
Alendronic acid is a bisphosphonate drug that is used to inhibit osteoclastic bone resorption .it works by attaching to hydroxyapatite binding sites to impair the ability of the osteoclasts to produce the protons necessary for continued bone resorption. It also inhibit osteoclast activity by promoting osteoclast apoptosis. (pubmed ) Patient group who are mostly taking this medication are postmenopausal women. As women reaches their menopausal age, oestrogen starts to deplete which causes their bones to…
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