The Effect Of Two Intensive Statin Regimens On Progression Of Coronary Disease

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Title Effect of two intensive Statin regimens on progression of Coronary Disease. Citation Nicholls J. Stephen, Ballantyne M. Christie, Barter J. Philip, Chapman M. John, Erbel M. Raimund, Libby Peter, Raichlen S. Joel, Uno Kiyoko, Borgman Marilyn, Wolski Kathy, Nissen E. Steven. Effect of two intensive statin regimens on progression of coronary disease. New England Journal of Medicine. 2011 November 15 (2015 August 24); 365(22). Introduction Clinical trials have shown that statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reducatse can reduce cardiovascular evenrts (^1). Statins reduce the rate of cardiovascular events by lowering LDL levels “bad cholesterol”. Guidelines used for prevention of cardiovascular disease have …show more content…

Secondary: the use of intravascular ultrasonography that examined the effect of antiartherosclerotic therapy on the progression of coronary artery disease (^5) Study Design -Prospective, randomized, double blinded clinical trial, multi-center study - Randomization was stratified according to geographic region (^5). - Inclusion criteria: - Patients 18-75 years old - Patients within this age group with at least one vessel with 20% stenosis that is indicated on a coronary angiography - Patients with target vessel for imaging with less than 50% obstruction - Patients who had not been treated with statins in four weeks where required to have an LDL level of less than 100mg/dL - Patients who have been treated with statins were required to have LDL level higher than 80mg/dL - Exclusion criteria: - Patients who have received intense therapy with statins for more than 3 months in the previous year - Patients with uncontrolled hypertension, renal dysfunction, heart failure or liver disease - Treatment: -Intravascular ultrasonography was performed on 1039 patients with coronary disease. Patients who met the inclusion criteria were randomly assigned in a ratio of 1:1 to receive either atorvastatin 40mg daily or rosuvastatin 20mg daily for a 2 week period to determine patients

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