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Lipid Lowering Therapy On Risk Of Recurrent Cardiovascular Events

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Lipid-lowering therapy has proven to be beneficial in reducing the risk of recurrent cardiovascular events in patients who have suffered a previous myocardial infarction (MI).1,5 However, it is unclear whether one statin is more effective versus another in reducing future incidence of acute MI and at what intensity is it beneficial.1,2 Myocardial infarction or acute myocardial infarction (AMI), also known as a heart attack, is due to a blood clot that occludes coronary arteries, which brings oxygen-rich blood to the heart.4,6 When there is a blockage in the arteries due to plaque build-up there is a decrease in blood flow to the heart impairing oxygen demand and supply.5,6 Reduction in the blood supply to the heart, if not treated…show more content…
The key terms searched include, secondary prevention, heart attack, atorvastatin, simvastatin, and pravastatin. The terms were combined with an “and” operator, and the following limits were applied: English language, human, and randomized controlled trial. The search returned 39 articles of which only 1 included a study which compared 2 different statins. The other articles were excluded because they were guidelines, review articles or were not specific to preventing a recurrence of myocardial infarction. Literature Analysis: The IDEAL study was a multi-centered, prospective, randomized, open-label, blinded endpoint classification trial (PROBE design).1,3 The study was conducted at 190 ambulatory care, and private specialist centers in Denmark, Finland, Iceland, the Netherlands, Norway, and Sweden.1,3 Recruitment and randomization was conducted from March 1999 to March 2001 and patients were followed up until March 2005.1,3 The objective of the IDEAL
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