Cardio- Nephroprotective Effects of Guava and Olive Leaf Extracts on Doxorubicin-Induced Toxicity in Rats
Abstract
Objective: Doxorubicin (DOX) is an anticancer drug that is known to increase oxidative stress in several organs. Our objective was to evaluate the possible cardioprotective and nephroprotective effects of guava leaf extract (GLE) and olive leaf extract (OLE) on DOX-induced toxicity in rats. Methods: Forty adult male albino rats were randomly divided into 4 groups of 10 rats each, as follows: a normal control group, a DOX group (a single dose of DOX; 30 mg/kg intraperitoneally), a GLE group (500 mg GLE/kg body weight), and an OLE group (500 mg OLE/kg body weight) for 12 d. DOX was administered in the DOX, GLE, and OLE rats,
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It has been demonstrated that the regular consumption of fruits and vegetables decreased the risk of certain malignancies (Tang et al., 2014). Therefore, fruits and vegetable phytochemicals can be considered as promising chemopreventive agents.
Despite Doxorubicin is the of drug of choice for cancer treatment because of its efficacy but it has many acute and chronic side effects some of which are irreversible especially in the heart. Our aim in the present study was to decrease these side effects in cancer patients using dietary antioxidants and natural products.(3&7)
New refrences
Herbal and medicinal plants have been extensively used as treatment of several human disorders. Psidium guajava L. commonly known as guava, considered as one of the most important traditional medicinal herbs Guava has been used for long time in folk medicines as a therapeutic agent for the treatment of a number of diseases, e.g., as an antiinflammatory, for diabetes, rheumatic pain, hypertension, wounds, ulcers, and reducing fever.4 Guava leaves extracts have various pharmacological effects.
The main components of guava including vitamins, tanins, phenolic compounds, flavonoids, essential oils, sesquiterpene alcohols and triterpenoid acids. These compounds are related to many health effects of guava [10].
Olive (Olea europaea L.) tree leaves have been widely used for traditional therapies in Mediterranean countries [11].Several experimental studies have shown
In personal health, there is a big lifetime decision to be made. Presented with two basic options, pharmaceutical medicines and herbal medicines, the choice must be made when the situation of illness arrives, which form of medication will be taken? First, the differences between the two types of medicines must be studies and understood by the user. According to the U.S Food and Drug Administration, a drug is defined as, “A substance (other than food) intended to affect the structure or any function of the body” (Center…). With this in mind, both herbs and scientifically produced medications are to be considered ‘drugs’.
What are some of the things that come to mind when you think of cancer treatments? Perhaps you envision some sort of chemotherapy treatment, or a bottle of expensive pills used to target specific genetic mutations that may have caused the horrid disease to develop. While these treatments have been proven to save some of cancers victims, research suggests that there is a natural cure that deems promising in curing cancer.
Cancer is one of the leading causes of death. What if there was a safe, natural herb that could work for nearly every type of cancer?
Cancer or the big C as it is commonly referred to by laymen is a scary word for people to hear or discuss. The exact cause of cancer is unknown, but is believed to be caused by many elements, including diet, chemicals, tobacco, radiation, and mutations that occur in the human body, as well as defective cells and genes. Experts know that cancer requires oxygen and nutrients to grow more cancer cells. The paper will explore the concept of angiogenesis, what it is, and how it impacts cancer, along with exploring activators and inhibitors to stop the growth of cancer. Natural products will be reviewed to highlight any potential value in eliminating and reducing the risks of getting any type of cancer.
Mulberry and blueberry are examples of the berries species that contain high antioxidants and low in calories. These berries may contribute in minimizing and preventing the risk of diabetes due to the presence of high amounts of phenolic compound and flavonoids such as anthocyanin. It may exhibit neuroprotective and anticancer activity (Wang Y, Xiang L, Wang C, Tang C, He X, 2013). The reaction of the antioxidants in berries related to the reduction of oxidative stress and inhibition of macromolecular oxidation in fruits that high in phenolic compound (Larson, 1988). The anthocyanin content also have other health-related function such as anticancer, antiaging and antiobesity. However, the research regarding these functions still in progress and some of the research still needs a further improvement. The rich content of poplyphenol in berries helps in reducing the oxidation and producing the insulin to reduce the blood glucose
Licorice root is used worldwide as a natural sweetener, as well as a flavoring agent. The main composition of plant Flavonoids and Isoflavonoids act as inhibition platelet aggregation, and anticancer, antioxidant (20). Aly et al.,2005(21) indicate that liqurice have potent anti-inflammatory reduction edema about 78.3 while diclofen about 73.9% also have anti-ulcerogenic activity associated with a reduced acid output and an increased mucin secretion, an increase in prostaglandin E2 release and a decrease in leukotrienes (22). Many volatile oil and vitamins such as B1,B2,B3,B6,C,E, Biotin, Foli acid, Pantothenic acid act as expectorant, laxative, liquiritin act as antitussive (23). Also contain Coumarins Herniarin and umbelliferone (24).moreover plant used for treatment of asthma , chronic fatigue, hormonal disturbance , antiviral, antibacterial , hepatoprotective, anti-oxidant , antiulcer, ant mutagenic, Hypothermic antioxidant, anti-inflammatory, relieve pain , expectorant, hypoglycemia,
other rapidly growing cells in the body. Chemotherapeutic drugs used to treat cancer are given to most of the people, which help to sustain the completion of cancer treatment (El-Sayyad et al., 2009; Sundaram & Sangavai, 2009). Besides this, the noxious side effects of chemotherapeutic agents include the devastating production of reactive oxygen species (ROS). Therefore, an escalating amount of facts suggest that a simultaneous treatment of chemotherapy and chemo-preventive agents with antioxidant action may augment the efficacy of chemotherapeutics (Lee et al., 2008;Aydin et al., 2011). Although the mechanism underlying the severe cytotoxicities of doxorubicin (DOX) is not fully clear, ROS are assumed to be a key factor in the toxicity of DOX and events controlling this oxidative injury are extensively appreciated (Reddy
Chemotherapy is the most used drug or combination of drugs in the United States primarily to combat malignant tumors at the cost of even damaging the healthy cells. The purpose of chemotherapy is to either slow down or halt the spreading of the cancerous tumor. Yet, there is another way that is not widely used to fight against malignant tumors and that is the holistic approach. The holistic approach is showing promise to combat cancer and that is to eat organic fruits and vegetables, take natural supplements and to eliminate refined sugars and oils to name a few. With the two different ways to combat cancer in mind, it would be beneficial for cancer patients to use the holistic approach instead of chemotherapy since it does not damage any of
Article: The more science studies whole foods the more we learn that they may ultimately be our salvation when it comes to curing major, life-threatening illnesses. Even a humble root vegetable like horseradish — mainly used as a condiment — is now being studied for it’s many health benefits. Now, for the first time science has identified and measured cancer-fighting compounds, known as glucosinolates, noting that horseradish contains approximately 10 times more glucosinolates than its superfood cousin, broccoli.
DMBA is an effective chemical used to induce breast tumorigenesis in rats. In this study, DMBA treatment led to the development of tumors by rats as revealed by tumorigenesis analyses and the histopathological examination. Treatment with lycopene reversed the pathological changes showing the efficiency of lycopene in breast tumor treatment. This result was in accordance with previous studies where lycopene alone or in combination with other products was proven to have anti-tumor activity.
Although herbs were once the only source of medication available, they may become the future of preventative treatment for Cardiovascular disease. Like everything else in the human body, the Cardiovascular System starts to age, with age comes complications, and sometimes even disease. This journal focuses on the prevention of these diseases by simply using herbs. To elaborate on this, lets first look into what the Cardiovascular System is. The Cardiovascular System is responsible for the moving and removing waste products from the body. Included in this system are blood, blood vessels, and mainly the heart. Some things focused on in this article are the Ethical considerations, the outcome, and the risks of this study.
As interest in the West has grown in Moringa, researchers and scientists have been studying the plant’s effects on cancer.
In the case of Infections, Intestinal Parasites, and several Liver conditions, Guduchi can be quite useful. It has a powerful immunomodulatory effect which results in a substantial boost in immune function. It stimulates hepatic function and is also well known for being hepato-protective. Guduchi, being an immune booster, assists in ridding the body of a wide range of infections, both chronic and acute.
Modern medicine and healthcare system have categorized herbal medicine as a natural remedy used when people can’t afford to purchase conventional drugs. They are perceived inferior because they cost less but the health benefits are endless. However, there have been various situations and instances that prove that herbal medicine is good for health.
ECGC is the most potent of flavonoids, and it helps fight against free radicals. Which is an atom and when their paired with unpaired valance electrons it makes the free radical extremely radioactive towards other things in the body which can lead to cancer. Green teas antioxidants interfere with the development of colorectal cancers, the antioxidants found in Chamomile tea also stunt the growth of cancer cells. White tea has the more dominant anticancer properties.