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The Effects Of Guava And Olive Leaf Extracts On Doxorubicin Induced Toxicity

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Cardio- Nephroprotective Effects of Guava and Olive Leaf Extracts on Doxorubicin-Induced Toxicity in Rats
Abstract
Objective: Doxorubicin (DOX) is an anticancer drug that is known to increase oxidative stress in several organs. Our objective was to evaluate the possible cardioprotective and nephroprotective effects of guava leaf extract (GLE) and olive leaf extract (OLE) on DOX-induced toxicity in rats. Methods: Forty adult male albino rats were randomly divided into 4 groups of 10 rats each, as follows: a normal control group, a DOX group (a single dose of DOX; 30 mg/kg intraperitoneally), a GLE group (500 mg GLE/kg body weight), and an OLE group (500 mg OLE/kg body weight) for 12 d. DOX was administered in the DOX, GLE, and OLE rats, …show more content…

It has been demonstrated that the regular consumption of fruits and vegetables decreased the risk of certain malignancies (Tang et al., 2014). Therefore, fruits and vegetable phytochemicals can be considered as promising chemopreventive agents.
Despite Doxorubicin is the of drug of choice for cancer treatment because of its efficacy but it has many acute and chronic side effects some of which are irreversible especially in the heart. Our aim in the present study was to decrease these side effects in cancer patients using dietary antioxidants and natural products.(3&7)
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Herbal and medicinal plants have been extensively used as treatment of several human disorders. Psidium guajava L. commonly known as guava, considered as one of the most important traditional medicinal herbs Guava has been used for long time in folk medicines as a therapeutic agent for the treatment of a number of diseases, e.g., as an antiinflammatory, for diabetes, rheumatic pain, hypertension, wounds, ulcers, and reducing fever.4 Guava leaves extracts have various pharmacological effects.

The main components of guava including vitamins, tanins, phenolic compounds, flavonoids, essential oils, sesquiterpene alcohols and triterpenoid acids. These compounds are related to many health effects of guava [10].
Olive (Olea europaea L.) tree leaves have been widely used for traditional therapies in Mediterranean countries [11].Several experimental studies have shown

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