Multiple sclerosis is an unpredictable, mostly paralyzing disease of the central nervous system that inhibits the flow of information inside the brain, and between the brain and body.
The myelin sheath is sort of a conductive blanket around nerves which assists nerve impulses and messages travel fast and effectively, it is made up of protein and fatty substances. Usually the myelin sheath is used to keep a fast pace up nerve cell transmission from the brain and spinal cord.
The nodes of ranvier are constrictions in the myelin sheath that border the axons of nerve cells, or neurons. They happen about one millimetre intervals along the body of the axon. There must be breaks in the myelin to conduct electricity in neurons. These spaces are
…show more content…
It is the electrical events that are conducted along the entire length of the nerve cell's axon. At threshold potential, special sodium channels called voltage-gated channels are triggered to rapidly open,at that time, so too are the potassium voltage gated channels triggered to open (they open very slowly). When opened this allows a large amount of sodium ions to rapidly enter the cell down their concentration gradients, this results in a rapid depolarisation. Once a key maximum potential is reached usually about plus 30 millivolts the voltage gated sodium channels close. The depolarisation stops. Focusing on the potassium channels now, by the time the action potential peak is reached these channels are fully opened. And now a large amount of potassium ions move out of the cell down their concentration gradient. The removal of positive charges results in the membrane potential becoming more negative known as repolarisation. The cell nown returns to its resting values the potassium channels are triggered to close but they close slowly resulting in hyperpolarization. Finally the potassium voltage gated channels close and hyperpolarization stops and the membrane potential returns to rest. This all happens within two …show more content…
How multiple sclerosis works is that white cells puncture the blood-brain barrier and they infiltrate the central nervous system. These white cells then damage/harm the myelin sheath that safeguards the nerve fibers which then forms lesions. More white cells will then appear from being drawn by chemical messages from the beginning white cells. Repair and scarring follow from the inflammation but some myelin will be permanently damaged. Impulses will then travel along the damaged nerves very poorly/slowly. In extreme cases nerve impulses don't travel at
Multiple Sclerosis (MS) is an autoimmune disease that attacks the central nervous system. The myelinated nerve cells get attacked which results in scars and lesions that destroy the myelin sheath. The reason for the body attacking its own nerve cells is unknown. Many believe that the cause of MS is from a virus, a deficiency in Vitamin D, or genetics. Studies are being done to find out what is the real cause of MS.
As well as these there are also the axon of the cell which is covered in myelin sheaths which carried information away from the cell body and hands the action potentials, these are small short bursts of change in the electrical charge of the axon membrane through openings of ion channels, off to the following neurons dendrites through terminal buttons at the end of the axons. Whenever an action potential is passed through these terminal buttons it releases a chemicals that pass on the action potential on to the next neuron through the terminal button and dendrite connection. The chemicals that are
Multiple Sclerosis (MS) a disease which the immune system attacks the protective sheath also known as the myelin that covers the nerves. Damages myelin disrupts the communication between the brain and the rest of the body. The nerves itself may weaken, process that is currently irreversible.
Multiple sclerosis is a chronic, progressive neurological disease affecting all aspects of life: physical, cognitive, emotional, and social (Abma). It is known as an autoimmune disease, Where the body’s immune system turns against the body and destroys the protective covering that surrounds nerve cells. This damage to the nerve cells causes many problems for the patient including weakness, muscle stiffness, poor coordination and balance, tingling, numbness, tremors, blurred vision, slurred speech, and memory and concentration problems (Bren)
Multiple Sclerosis, commonly known as MS is an autoimmune disease of the central nervous system. Scientists have been studying MS since the 19th century. In MS, the body’s immune system produces cells and antibodies that attack myelin in your brain which is essential for the nerves in your brain and spinal cord to conduct electricity to perform its function. The attack on myelin results in vison loss, paralysis, numbness, muscle weakness, difficulty walking, stiffness, spasms, and bladder and bowel problems. MS has varying degrees of severity and affects people between the ages of 20-50, mostly women. Although there are treatments, there is no cause and cure yet.
Multiple sclerosis is characterized by inflammation, demyelination, and axonal damage in the brain and spinal cord with a loss of myelin that covers the axons. As the myelin sheath regenerates, scar tissue forms, which looks like plaques on magnetic resonance imaging scans. Multiple sclerosis arises when immune-mediated inflammation activates T cells and causes the T cells and immune mediators to cross the blood-brain barriers into the CNS and attack oligodendrocytes (ie, a type of neuroglial cell with dendritic projections that coil around axons of neural cells). When the oligodendrocytes are attacked, the myelin sheath is replaced by scar tissue, which forms throughout the CNS. As a result of damage to the myelin sheath, the ability to transmit and conduct nerve impulses along the spinal cord and in the brain is interrupted, leading to muscle weakness, fatigue, loss of coordination, balance impairment, and cognitive and visual disturbance (DeLuca & Nocentini, 2011). This disease is characterized by unpredictable remissions that occur over several years. During periods of remission, the myelin sheath usually regenerates and symptoms may resolve, but the myelin cannot be completely repaired. As the disease progresses, the myelin sheath is destroyed and nerve impulses become much slower or absent and symptoms worsen. When degeneration exceeds self-repair ability, permanent disability results. There are four defined clinical types of
Multiple sclerosis is an unpredictable, crippling neurological disease of the central nervous system, which affects the flow of information within the brain, and between the brain and body. The name is this disease refers to multiple areas of scarring throughout the brain and spinal cord. This scarring is a result of what happens when the body attacks itself. A substance called Myelin surrounds the nerves to help protect them (Healthline.com, 2015). Multiple Sclerosis is thought to occur in a genetically susceptible individual (although there is no evidence to show that the disease is directly inherited) influenced one or more environmental factors. MS is thought to be an autoimmune disease, however others disagree as the target of the immune
Multiple Sclerosis is a long-lasting disease that can affect your brain, spinal cord, and the nerves in your eyes. It can cause problems with your vision, balance, muscle control, and other bodily functions. There is no cause for Multiple Sclerosis but there are many symptoms that can lead you to think that you do have this special disease. Starting with vison loss, pain, fatigue, and impaired coordination. Some people can be symptom free, meanwhile some have those chronic symptoms that never go away. When you begin to have MS, it starts in your immune system, then attacks your central nervous system. There are more than 350,000 people in the United States have this progressive disease. Including Northern Europe, Southern Australia,
Multiple Sclerosis is an autoimmune disorder affecting movements, sensation and bodily functions. The cause of MS is by the myelin sheath being destroyed in the brain and spinal cord. The immune system attacks myelin sheaths which is a fatty substances that surrounds the nerve axons that makes it possible for the transmission of nerve impulses. When the myelin sheath are destroyed the nerves impulses that are being triggered to the brain and spinal cord get out of disrupted that provoke the messages to become slower and less efficiently. There are four types of MS people could experience which are Relapsing-remitting multiple sclerosis (RRMS), Secondary –progessive multiple sclerosis (SPMS), Progressive-relapsing multiple sclerosis (
Imagine a world where you have been diagnosed with a disease that has no cure and left your world upside down because your body has turned against you. Multiple Sclerosis is a potentially debilitating disease that is caused by the body’s immune system attacking the Myelin sheath of nerve fibers throughout the body (Multiple Sclerosis, 2017). This, in turn, creates miscommunication or lack of communication in the body, which can eventually lead to permanent disability. For those who are diagnosed, there are various symptoms to watch for and while not curable, it is treatable.
Multiple sclerosis, or MS, is a disease of the central nervous system. The central nervous system is made up of the brain and spinal cord. Both have nerve fibers that are wrapped in a myelin sheath. In MS, the myelin sheath becomes inflamed and gradually is destroyed. With the destruction of the myelin sheath comes an array of symptoms that may include numbness or tingling, balance problems, weakness, muscle spasms, and blurred vision.
M.S., as some would call it, also known as multiple sclerosis is a neurological disease. This disease, in particular, could also be viewed as an autoimmune disorder. It is not nearly as fatal as the sexually transmitted disease (AIDS), yet it can be just as debilitating. What exactly is Multiple Sclerosis? Multiple sclerosis is a disease in which the immune system malfunctions and begins to attack the myelin sheath. The myelin sheath is an insulating cover
Multiple Sclerosis (MS) is a neurologic disease that affects the Central Nervous System (CNS) through cellular immune response and the demyelination of CNS white matter (McCance et al., 2014, pp. 630–633). The initial causes of MS are unknown however, it is believed that it could possibly be due to an immune response to an initiating infection or an autoimmune response to CNS antigens on the myelin itself (Brück, 2005) (Miljković and Spasojević, 2013). MS is a result of the degradation of the myelin sheath surrounding neurons and therefore disrupts the transmission of action potentials along these cells. MS can display itself in the form of symptoms ranging from muscle weakness to trouble with sensation and coordination (NHS, 2016). The degradation of myelin leads the body to attempt to remyelinate the neurons, a process that in turn leads to the thickening of the cell by glial cells and this causes lesions to form (Chari, 2007). It is this thickening (sclerae) from which the disease gets its name. Sufferers of MS can either have a relapsing type of MS, in which there are episodes that lead to the worsening of symptoms for a period of time, or a progressive type of MS where symptoms gradually progress and worsen (McCance et al., 2014, pp. 630–633).
Multiple Sclerosis is a disease which affects neurons in the central nervous system. It erodes the myelin sheath that covers the axons of the neurons. As such, the transmission of nerve signals does not occur as efficiently as it should. The myelin sheath gets disintegrated due to an autoimmune disease, where the immune system attacks its own tissue rather than foreign tissue.
Multiple sclerosis is a neurological disorder of the central nervous system or CNS. The CNS is the brain, spinal column and optic nerves. With MS the body’s immune system functions abnormally and damages the covering (or sheath) of the nerve fibers. This sheath, made of fatty substances, is a protective layer for the nerves, similar to insulation. The sheath helps the brain to communicate with other parts of the body.