The Pathway Of The Enzyme Pathway

2090 WordsDec 15, 20169 Pages
The RAS protein was examined, and its significance to involved pathways. This review highlights modern studies to solve problems of constitutively activated RAS. Lysine-104 silences RAS signaling pathways when acetylated. Andrographalide and derivatives inhibit RAS from using GEF to exchange GDP for GTP. Mutant K-RAS cells are selectively killed by lanperisone, a muscle relaxant. R-Ras binds to FlNa, causing overall increases in cell migration, but questionable cell adhesion changes. RAS is capable of modulating circadian rhythm functions through over-expression or under-expression. Modern treatments of RAS mutants can be compounded with newly discovered functions of RAS to gain promising research data. RAS is a biochemical molecule that is constantly being researched, and new roles and functions are consistently being discovered. The three main subcategories of RAS are K-RAS, N-RAS, and H-RAS. There is also a lesser known variant known as R-RAS. They are all functionally very similar, but function at different general areas within the cell. To discuss the functionality of RAS, it is important to go over the mechanism where it usually functions at the receptor tyrosine kinases (RTKS). RTKS are a specific type of cell-surface receptor, the other major type being G-protein coupled receptors (GPCRs). There are a variety of ligands that can bind, including platelet-derived growth factors, epidermal growth factors, and insulin. The structure of an RTK consists of one hydrophobic
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