The Respiratory Disease ( Brd ) Is An Economically Important Disease Of Feedlot Cattle

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Bovine respiratory disease (BRD) is an economically important disease of feedlot cattle, causing an estimated global economic loss in excess of $3 billion per year. BRD is a multifactorial disease caused by various bacterial and viral pathogens, contributing to significant morbidity and mortality in feedlot cattle. Stress due shipping, poor health condition, crowding, and mixing of calves comprises their immune system making them prone to BRD pathogens. Use of antibiotic is important part of prevention and control strategies in feedlot cattle. Histophilus somni is one of the bacterial pathogens commonly associated with BRD. Antimicrobial resistance profiles of 58 H. somni isolates collected from 2012 to 2015 from clinical cases of BRD will be compared to 31 isolates from 1980’s to investigate if resistance has changed since that time. Genes responsible for resistance in H. somni will be analyzed and genetic relatedness of old and new isolates will be determined. Copper and zinc use in feed is found to be responsible for antibiotic resistance in other bacteria. We are suspecting similar phenomenon in H. somni that will be determined by looking at co-location of Cu, Zn and tetracycline resistance genes. Lack of information about prevalence of antibiotic resistance in H. somni makes it difficult to judge its contribution to treatment failures. Results of this study can be used in making decisions for effective use of antibiotics in feedlot facilities and mitigate risk of

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