The Role Of Plasma Bnp On Adults With Congestive Heart Failure

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Brain natriuretic peptide (BNP) is a cardiac hormone with diuretic, natriuretic, and vasodilator properties. Measurement of plasma B-type natriuretic peptide concentrations is increasingly used to aid diagnosis, assess prognosis, and tailor treatment in adults with congestive heart failure. Recent studies suggest that the peptide is also useful in pediatric patients. The diagnostic role of plasma BNP in neonates admitted to the NICU has shown promise as an aid in diagnosis in neonates with signs of congenital heart disease, as a biomarker of bronchopulmonary dysplasia, patent ductus arteriosus, persistent pulmonary hypertension of the newborn, a predictive biomarker of the response to indomethacin in preterm infants, and, more significantly, in acute heart failure.

Keywords: brain natriuretic peptide (BNP); bronchopulmonary dysplasia (BPD); patent ductus arteriosus (PDA); persistent pulmonary hypertension of the newborn (PPHN)
Accepted for publication July 2015
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Brain natriuretic peptide (BNP) is a cardiac natriuretic hormone mainly produced by cardiomyocytes and is characterized by diuretic, natriuretic (substances secreted from the ventricles of the heart in response to changes in pressure that occur when heart failure develops and worsens), and vasodilatory properties (Figure 1).¹ In particular, BNP is produced by cardiac ventricular cells in response to volume expansion and increased pressure load such as in heart failure.2 So why not name the

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