Thyroid Disorder27
Pathogenesis: both hyperthyroidism and hypothyroidism can lead to amenorrhea, though most commonly it present as primary amenorrhea in patients with hypothyroidism. Low levels of thyroid hormones, T3 and T4, stimulate the hypothalamus to produce thyrotropin-releasing hormone (TRH), which stimulates both thyroid stimulating hormone (TSH) and prolactin production in the anterior pituitary. High prolactin levels inhibit GnRH production in the hypothalamus, which is needed for LH and FSH activation in the anterior pituitary. Without LH and FSH, ovarian follicles cannot mature and menstruation does not occur.
Diagnosis: patients who present with signs and symptoms of hypothyroidism, such as low energy, weight gain, cold intolerance, and amenorrhea, should be tested for the disorder with serum measurements of TSH and free T4. High TSH and low free T4 levels suggest hypothyroidism. Conversely, measurement of anti-thyroid antibodies may also be tested, such as anti-thyroglobulin, anti-thyroid peroxidase, and anti-TSH receptor. Clinical suspicion should still be present when patients do not have these characteristic hypothyroid symptoms, but present with primary amenorrhea in the
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Imaging may show the presence of testes, karyotype analysis demonstrates a 46XY karyotype, and serum testosterone concentrations in the normal adult male range. CAIS should also be suspected in females with inguinal hernias or inguinal or labial masses as about 1-2% of these individuals may have CAIS. Newborns with a female phenotype can also be diagnosed if prenatal karyotyping identifies a 46,XY karyotype. In CAIS, testes may be located in the abdomen or inguinal region. If the site and size of the testes cannot be elucidated by ultrasonography then MRI may be more
Laboratory Report/ Miranda Tefft/ Homeostatic Imbalances of Thyroid Function/ Aline Potvin/ 11.18.2014/ Page [2] of [3]
pituitary is not creating as much TSH. This would cause the Thyroid to stop producing T4
Hypothyroidism, while a common disorder, is often misdiagnosed due to its ability to mimic other common health problems. A simple, yet specialized blood test, coupled with a complete medical history, will allow the experts at RCMC Medical Center to not only diagnose the problem in a timely manner, but also develop a treatment plan based on the results, and your personal lifestyle, with the end goal of returning you to the level of health and wellness you
My grandmother suffered with thyroid and use to always ask me if I had thyroids. I remember a time when she told me to get a quarter and some iodine to put on my stomach above my navel. She told me if it changed colors that I had thyroids. Also, because I felt so drained most of the time and would swell in my body often, she had me to consult with my physician about the matter. My grandmother was a very intelligent woman that was very health conscience about herself and her family.
She is currently on a regimen of Armour Thyroid 90 mg daily. Her TSH was last checked in November. She previously was on levothyroxine, but cannot recall the reason why she was switched. She thinks it was changed by her prior endocrinologist. She does not recall having a specific side effect or problem with the levothyroxine and would be interested, potentially in switching back to that because it is more considered standard therapy. She does feel sometimes that she is having difficulty losing weight, even though she is trying. Her weight in the office is actually down 2 pounds from her last visit in May, but overall up 5 pounds from her last visit a year ago in June. She also feels bloated sometimes, occasionally has constipation, but no other symptoms of hypo or
The author Azeez Farooki MD in “Hypothyroidism: What You Should Know about Your Treatment”, focused on the drug levothyroxine which replaces the thyroid hormone that is not being produced in the body of people with hypothyroidism. Hypothyroidism is very common and it affects more than 27 million people and mostly women and elderly. Levothyroxine is a synthetic medication and some people that take it have a more difficult time tolerating it or absorbing it the traditional way. The doctor might be able to prescribe a more natural “pure” levothyroxine formula to those people. The symptoms of hypothyroidism are very similar to many other diseases which sometimes can be overlooked and people become undiagnosed. It’s important to keep great communication with the doctor to have success in treatment. The treatment is usually a lifelong situation and the doctor
Mrs. J.P. is a 30-year-old African-American female who presents to the local health department for her annual women’s health exam and establishment of primary care. Mrs. J.P. requests a pregnancy test be performed due to her recent absence of menses. Mrs. J.P. states she and her spouse have been attempting pregnancy for approximately 3 months; however, with each missed cycle, pregnancy tests have been negative despite corresponding notable fatigue. Mrs. J.P. explains her current uninsured status and frustration with walk-in clinics stating recent use of multiple clinics for “simple things” without resolution. Mrs. J.P. lists her primary complaint as difficulty sleeping due to significant heart pounding in addition to her fertility concern. When encouraged to also explain recent symptoms requiring walk-in clinic assessment and completion of a health history form, she explains her ongoing diarrhea, current hand tremor, and recent onset of eye pain. She identifies all symptoms as explainable as Mrs. J.P. attributes a gluten allergy to her diarrhea, a family history of glucose abnormalities to her hand tremor, and seasonal allergies to her eye pain although medical assessment and diagnostics have not been performed. When encouraged to
Tympanic membrane perforations are very common disease. There are many factors that can contribute to this condition. Trauma, accidents, foreign objects on the ear and Middle ear infections frequently results in the accumulation of fluids in their middle ear causing a pressure capable to rupture the
TSH not only stimulates the thyroid gland to churn out more hormones. If in excess, can cause overwhelming cell growth and division to result in goiter.
Hypothyroidism is caused by the thyroid’s gland inability to produce thyroid hormone as required by the body. The diagnosis of hypothyroidism requires the laboratory testing of the thyroid stimulating hormone known as TSH. When the TSH is found to be elevated, a clinician should repeat the test along with a free thyroxine (T4) measurement. If the TSH is found to be elevated, while the T4 is normal, the patient is said to suffer from subclinical hypothyroidism. However, if the TSH is elevated and the T4 is low, the diagnosis is primary hypothyroidism (Gaitonde et al., 2012).
According to The National Institute of Diabetes and Digestive and Kidney Diseases, diagnosis of Hashimoto’s thyroiditis begins with a physical exam and medical history. A goiter, nodules, or growths may be found during a physical exam, and symptoms may suggest hypothyroidism. Health care providers will then perform blood tests to confirm the diagnosis. Diagnostic blood tests may include the TSH, which, if above normal lab values, means a patient has hypothyroidism. Blood tests also include T4, which is the amount of thyroid hormone in the blood. In hypothyroidism, the blood lab values are lower than normal. The anti-thyroid antibody tests look for presence of thyroid autoantibodies. Most people with Hashimoto’s disease have these antibodies; however, hypothyroidism isn’t always caused
My patient is a 30-year-old mother of two who presented with symptoms of fatigue, cold intolerance, and tearfulness. She was later diagnosed with Hashimoto’s Thyroiditis six months after the birth of her second child. With the addition of a thyroid hormone, prescribed by her doctor, the patient is doing well and living an active life with her husband and two children.
Hypothyroidism is defined by a reduction in the release of the main thyroid hormones, Thyroxine (T4) and Triiodothyronine (T3). These hormones are essential in the homeostatic maintenance in the area of metabolic function (PetMD, 2017). This condition is not life-threatening and is usually very inexpensive to treat (WebMD, 2017). While there are many causes for hypothyroidism, the common causes include shrinking of the thyroid gland, tumors or cancer of the thyroid, congenital disease, iodine deficiency, and sometimes even an autoimmune issue where the body attacks its own thyroid. The risk for this disease appears to increase when the animal is spayed or neutered for currently unknown reasons (WebMD 2016). This condition is most
In a normally functioning body, Thyroxine (T4) and Triiodothyronine (T3) are hormones produced by the thyroid gland. They help control the rate at which the body uses energy and are regulated by a feedback system. Thyrotropin or Thyroid-Stimulating Hormone (TSH) from the pituitary gland stimulates the production and release of T4 (primarily) and T3 by the thyroid. Most of the T4 and T3 circulates, bound to protein, in the blood. A small percentage is free (not bound).
Hyperthyroidism is caused by an excess of thyroxine (T4) or triiodothyronine (T3), or both. This excess is a result of a malfunction of the thyroid gland as indicated by the picture below. There are many different symptoms of hyperthyroidism, some of the most common being major weight loss despite having a insatiable appetite, anxiety, heat intolerance, fatigue, weakness, hyperactivity, irritability, apathy, depression, and sweating. In addition, many experience shortness of breath, loss of balance, nausea, vomiting, osteoporosis, and diarrhea. However, those who undergo hyperthyroidism later in life may not experience most of these symptoms at all and instead only feel constantly fatigued and considerable weight loss. Nonetheless, neurological symptoms may occur in addition to the physical manifestations. These neurological symptoms include tremor, chorea (ticks), myopathy (muscle weakness), and temporary but periodic paralysis. There are a variety of ways to treat hyperthyroidism, depending on the age of the patient, the size of their thyroid gland, and their general health. The most common treatments include beta-blockers, which do not actually cure hyperthyroidism but mask some of the symptoms such as tremors, anxiety and so on. This, however, is not advised for those with heart or lung problems. Another possible treatment for this disease is radioactive iodine, or RAI. RAI therapy is the most common treatment for hyperthyroidism