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Transactional Anisotropy Case Study

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Background: Diffusion tensor imaging (DTI) is an imaging technique used to assess the microstructure of cerebral white matter (WM). It is a more powerful test for white matter abnormalities than CT scan or conventional MRI. DTI takes an advantage of the similarity between the fibrous structure of neuronal axons and the anisotropy (the directional flow of particles) in a crystal. In white matter tissue, the diffusion water molecules is constrained according to the density and orientation of axon fibers. Fractional anisotropy (FA) is a measure of the anisotropic character of white matter tissue, and higher FA values are correlated to the increased fiber density and myelination. Traumatic brain injury (TBI) is a common causes of white matter abnormalities. However, due to its traumatic etiology, TBI is often comorbid with with a number of psychological disorders like PTSD , depression, and generalized anxiety disorder. This makes it difficult to diagnose TBI through a standard neuropsycological evaluation, especially in mild …show more content…

She was evaluated at St. Luke’s Hospital and received 10 stitches on the back of her head. After the accident the patient reported intermittent headaches and dizziness, difficulty concentrating, insomnia, anxiety, impaired memory and reading comprehension, and distressing flashbacks of the incident. A neuropsychological evaluation found her symptoms to be in the severe range of the Beck Anxiety Inventory, and she was diagnosed with PTSD and Post-Concussion Syndrome. The evaluation found a direct causal link between her symptoms and the incident. The patient’s symptoms were consistent with mild TBI. However, the presence of PTSD (which shares symptoms like impaired attention and irritability) complicated a differential diagnosis (Brenner et al. 2009). A DTI study was ordered to assess possible

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