Result:
In this section of the study, the authors explain all steps in more details and clearly state the results between the control and treatment groups. The different parts of the results sections include: in vitro differentiation of ABMCs, neurological functional recovery in ABMC-treated canine model, localization of ABMCs at the spinal cord injury site, and molecular and electron microscopic features of ABMC-induced remyelination. Each part of the result section has appropriately been addressed with pictures and graphs, which truly helped me in understanding the respective results. The explanation is clear and understandable in each part since the investigators appropriately compared the findings between control and treatment groups.
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Therefore, the authors concluded that autologous grafting of ABMCs therapy was an effective treatment for dogs’ model of spinal cord injury.
Bias and weaknesses: I believe that the investigators have correctly protected the study from information, selection, and confounding biases. By doing this, they increase the validity and reliability of their study.
Further study: the authors suggest that further study about interrogating of potential mechanisms of repair will reveal the roles of ABMCs in mediating spinal cord injury repair. This suggestion indicates that the authors were aware of their study limitations, which prevented them in determining and explaining the physiological roles and mechanisms of AMBMCs in the process of spinal cord injury repair. By correctly pointing out the limitation of the study and suggesting the further study, the authors have decreased the possible impact of the limitation on the validity of the study.
Overall impression:
Who should be the target audience? Since the spinal cord injury is one of the most common disease in canine and human, health professional in both the veterinary and human filed should be the target audience of this study. The findings of this study may act as a really important source for the future finding of a definitive cure for spinal cord injury in both canine and human. Beside the study result, which may be applicable to human as the authors mentioned,
Directions: Read the case study below and complete the questions at the end. You will form small groups in class to collaborate and produce your final answer.
The victim was court ordered to be admitted at the Specialized Treatment Facility by Harrison County Youth Court on 04/27/16; he will be admitted for six months and the expected discharge date is 10/27/16. The reporter stated John was has been diagnosed with bipolar disorder, ADHD, marijuana abuse, mood disorder, severe mood swings, disruptive behavior, border line dyslectual disorder, basic personality disorder, mental incompetance; John is unable to function on his age level and has a very low IQ; John is unable to read, write, and count. Mr. Young stated John will never be able to live on his own and will always need assistance. During a session with John on 04/28/16, he disclosed that his father punched him in the face but that the details
A Spinal Cord Injury is damage to any part of the Spinal Cord nerves at the end of the Spinal Canal. Every Year, 17,000 Spinal Cord Injuries are reported in the USA alone. The Most Frequent age for Spinal Cord Injuries is 19. Almost 200 Spinal Cord Injuries were reported for High School Football. People who suffer from SCI (Spinal Cord injuries) can experience muscle weakness, poor coordination, and overactive reflexes.There is many
Before we determine how stem cells can treat various diseases including spinal cord injuries, let us first
Although the physiology and function is somewhat different in rodents and human spinal cords there are many biological functions that are conserved in vertebrate animals (2). In many spinal cord injuries, rat models are employed to study cell death, inflammation, and regeneration (2). In surgical modeling, recapitulating the physiology is important to insure surgical techniques can be employed across species. Non-human primates contain spinal cords that are more like humans due to closer evolutionary distance (3). Using both model organisms can help to answer questions on the cellular level as well as the macroscopic concept of
The limited space within the vertebrae actually plays an important roll in spinal cord injury. Once the initial injury occurs the body, as with every other part of the body, tries to protect the injured area with swelling. But the swelling occurs within the small confines of the spinal column and causes further damage to the surrounding tissue. It has only recently been discovered how much of an impact this secondary damage has. One of the areas of crucial ongoing research is on what kind of window of opportunity medicine has in treating these types of injuries and still attaining the best recovery.
This device is designed to help heal horses with potentially life threatening conditions such as a broken leg or a nerve block. When horses are diagnosed with one of these conditions, the owner often decides to have the animal euthanized because a full recovery to the horses’ previous potential is highly unlikely and time consuming. The project started by Dr. Montgomery gives these horses the possibility to recover fully by
A Spinal cord injury is a harm to one or all parts of the spinal cord. A spinal cord injury can affect many aspects of a person’s life such as making him weak and unable to perform daily activities. There are two factors that matter when it comes to spinal cord injury: the part of the spinal cord that is affected and the seriousness of the injury. Moreover, the seriousness of a spinal cord disease is distinguished by two terns: complete and incomplete. A spinal cord injury is complete, when it’s hard or become impossible to move the lowest part of the injured spinal cord. On the other hand, a spinal cord injury is incomplete, when it still possible to move the lowest part of your spinal cord even after an injury. Furthermore,
According to viacord.com there are over 80 life-threating diseases and disorders that can be treated using the stem cells found within cord blood. Doctors are still discovering diseases, disorders, and cancers that can be treated. In 2010 a study was published in the Spinal Journal, this study found that in rats, the newborn's stem cells could can improve the neurologic function after undergoing a spinal cord injury. Researchers discovered that over a six-week period that the locomotor function in the rats that were treated with cord blood was significantly better than the rats the weren’t injected with the cord blood. It may only be the treatment of spinal cord injuries in rats as of now, however with the revelation it is only a matter of time until humans are being treated. Childhood Leukemia is one of the main illnesses that has been treated in humans by cord blood. Leukemia is a type of cancer where it affects a person’s blood cells. This cancer normally targets white blood cells produced from your bone marrow, this causes the white blood cells to be abnormal resulting them from performing properly. Patients diagnosed with leukemia normally receive radiation and chemotherapy in hope that that will cure them of this cancer. Many patients are also receiving stem cell transplants as well, this is where cord blood comes into play. By receiving a stem cells, the new stem cells can be used to restore healthy bone marrow by
Lumbar Spinal Stenosis (LSS) affects a significant proportion of people in the population and can cause discomfort, limit activities of daily living, and can lead to significant disability. Even though numerous technological advancements have been made in the treatment of LSS, its management continues to be a challenge for both patients and healthcare professionals. Spinal Stenosis is a condition characterized by either narrowing of the spinal canal, also known as the Central Stenosis, or narrowing of the vertebral foramina (Delitto et al., 466). The combination effect of the loss of disc space, osteophytes, and hypertrophic lingamentum culminate to LSS (Genevay and Atlas 253). LSS is referred to as degenerative arthritis and the foraminal narrowing leads to a condition referred to as neurogenic claudication. Because of this narrowing, the spinal cord, and the spinal nerves are compressed thereby causing painful symptoms in the organs served by the affected nerves (Fishman 1141). Patients with this condition present with symptoms ranging from low back pain, general weakness decreased sensation to numbness of the limbs (Delitto et al., 467). Walking becomes a problem for people with this
Based on the neurological exam, Mr. Hendrix injury occurred primarily in the lumbar region. The Lumbar region which is located around the lower back of the body, which is also the area where Mr. Hendrix said he first felt pain immediately following the incident. The lumbar region controls most of the lower portion of the body. Lumbar 1 -3 affected his hip flexion, Lumbar 4 inhibited Mr. Hendrix’s ability to extend his knee, and Lumbar 5 affected his ability to dorsiflex his ankle. The reason that the spinal cord effects this region is due to a bundle muscle fibers being intertwined with those sections, also known as Myotome. This injury is recognized in the medical industry as Paraplegia.
Spinal stenosis treatment options have evolved over time and with surgical advancements. Treating spinal stenosis envisages several factors like soothing pained nerve fibers as these are impinged by the narrowed vertebral foramina by following.
A review of the literature regarding spinal immobilisation has been undertaken using databases for PubMed, MEDLINE, CINAHL, OVID and Cochrane EBM. Reviews were electronically searched using the subject headings “spinal injuries”, “spinal immobilisation” and “management of spinal injuries”. The results generated by the search were limited to English language articles and reviewed for relevance to the topic. The aim of this literature review is to compare and contrast the views on spinal immobilisation and to achieve a better knowledge of evidence based practice.
It also could lead to a way to repair damaged nerves by cloning the nerve cells from the injured person.
Every year, thousands of individuals worldwide are affected by Spinal Cord Injury (SCI), a devastating neurological disorder that, unfortunately, remains without an effective therapy, since the current approved approaches are essentially palliative1.