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Treatment Group Case Study

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Result:
In this section of the study, the authors explain all steps in more details and clearly state the results between the control and treatment groups. The different parts of the results sections include: in vitro differentiation of ABMCs, neurological functional recovery in ABMC-treated canine model, localization of ABMCs at the spinal cord injury site, and molecular and electron microscopic features of ABMC-induced remyelination. Each part of the result section has appropriately been addressed with pictures and graphs, which truly helped me in understanding the respective results. The explanation is clear and understandable in each part since the investigators appropriately compared the findings between control and treatment groups.
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Therefore, the authors concluded that autologous grafting of ABMCs therapy was an effective treatment for dogs’ model of spinal cord injury.
Bias and weaknesses: I believe that the investigators have correctly protected the study from information, selection, and confounding biases. By doing this, they increase the validity and reliability of their study.

Further study: the authors suggest that further study about interrogating of potential mechanisms of repair will reveal the roles of ABMCs in mediating spinal cord injury repair. This suggestion indicates that the authors were aware of their study limitations, which prevented them in determining and explaining the physiological roles and mechanisms of AMBMCs in the process of spinal cord injury repair. By correctly pointing out the limitation of the study and suggesting the further study, the authors have decreased the possible impact of the limitation on the validity of the study.

Overall impression:
Who should be the target audience? Since the spinal cord injury is one of the most common disease in canine and human, health professional in both the veterinary and human filed should be the target audience of this study. The findings of this study may act as a really important source for the future finding of a definitive cure for spinal cord injury in both canine and human. Beside the study result, which may be applicable to human as the authors mentioned,
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