CANCER DRUG RESISTANCE
Introduction:
• Treatment of cancer varies person to person depending on the variety in individual factors because every cancer has specific pathological and molecular characteristics such as location, health and extent of disease.
• The main part is to destroy the cancerous cells by least harming the normal tissue. Tumors can be present in the parts of the body where drug cannot easily penetrate or could be protected by the local environments due to increase tissue hydrostatic pressure or altered tumor vasculature.
Chemotherapy:
• There are several treatments to combat cancers which can work well alone or in combination with sequentially or simultaneously. Of those treatments the most
…show more content…
• Today we can talk about drug resistance in two classes, target specific and target nonspecific.
• In old times termed as acquired drug resistance and intrinsic drug resistance respectively.
• Drug resistance in cancer is a term used, which means that a patient having cancer has been resistant to the chemotherapies.
• Drug resistance means the decrease in the efficacy of a drug. Drug resistance may develop at once or the drug becomes ineffective overtime.
• When cancer becomes resistant to a lot of structurally different and unrelated chemotherapies then it is called multidrug resistant cancer.
• It is also known as Antineoplastic resistance and in this the cancerous cells become resistant to drugs by a lot of mechanisms.
Intrinsic drug resistance:
• This type of resistance means that an organism or cell have a characteristic property which make all the normal members of the specie tolerable towards particular drug or any specific chemical change in its environment.
• In that case the feature or property responsible for the resistance is inherent and integral property of the specie which has arisen over the course of evolution.
• All the cells whether normal or cancerous exhibit a degree of intrinsic resistance to the compounds they normally encounter.
• In mammalian cells the rate of division of the cells is also an important in the case of intrinsic cancer drug resistance.
• It is the fact
Targeted therapy, which first became available in the late 1990s, has had a significant impact on the treatment of cancer. Currently, because of advancement in the field of technology, various types of therapies are discovered to treat cancer. In this essay, targeted therapy is defined as a therapy in which various drugs or other substances are used to recognize and kill the cancerous cells without harming the normal cell (National cancer institute, 2014). Effectiveness refers to the degree in
What are some of the things that come to mind when you think of cancer treatments? Perhaps you envision some sort of chemotherapy treatment, or a bottle of expensive pills used to target specific genetic mutations that may have caused the horrid disease to develop. While these treatments have been proven to save some of cancers victims, research suggests that there is a natural cure that deems promising in curing cancer.
Cancer is a genetic disease caused by certain changes to genes that control the way our cells function, especially how they grow and divide. Genes carry the instructions to make proteins, which do much of the work in our cells. Certain gene changes can cause cells to evade normal growth controls and become cancer. Genetic changes that promote cancer can be inherited from our parents if the changes are present in germ cells, which are the reproductive cells of the body (eggs and sperm). Such changes, called germline changes, are found in every cell of the offspring. In general, cancer cells have more genetic changes than normal cells. But each person’s cancer has a unique combination of genetic alterations.
Significance: understanding the mechanism of drug resistance in cancer leads to developing more potent drugs.
There are many different type of cancers, there are also many different types of treatments. One of the most known types of treatments would be chemotherapy. Chemotherapy can be used for a wide range of different types of cancers and diseases, and each of the different types of cancers or diseases require a different group, and sometimes order, of chemicals to properly treat the cancer or disease. These chemicals include: Alkylating agents, Antimetabolites, Anthracyclines, Topoisomerase inhibitors, mitotic inhibitors, corticosteroids, and more. Each of these drugs previously listed have its own cancer type(s) or disease(s) that it can assist in treating. Some of these cancers include: Leukemia, Lymphoma, Hodgkin disease, multiple
Cancer is described as the abnormal growth of cells. Normal cells are replaced with abnormal cells in which their deoxyribonucleic acid (DNA) has been damaged or augmented (McCance & Huether, 2014). Cancer cells with their various DNA changes are characterized by growing uncontrollably, being immortal with an unlimited lifespan
In order to become cancerous a cell has many molecular changes that can occur including: tumor suppressor gene inactivation, oncogene activation, telomerase lengthening, ability to evade apoptosis, and angiogenesis (Mechanisms in Medicine, 2012). There are a few particular
They may be applied to bloodstream or directly to a cancer site. Chemotherapy typically refers to the destruction of cancer cells, however some may include antibiotics or other medications to cure an illness or infection. Often, chemo is used alongside other treatments. Physical activity is important and it’s been found that patients who regularly exercise after chemotherapy treatment have a much lower risk of cancer recurrence. Chemotherapy generally has 5 goals; total remission, combination therapy, delay/prevent reoccurrence, slow down cancer progression and relieve cancer symptoms. The objective is to prevent cell division using cytotoxic drugs, to target cancer cells food source, enzymes and hormones that they need in order to grow, and to stop the growth of new blood vessels that supply the tumor. Patients can either receive monotherapy where they’re just given one drug, or combination where the patient receives more than one drug. These courses of chemo can be just a one day treatment or last for a few weeks, it depends on the type and stage of the cancer basically how advanced it
Cancer cells displayed marked alterations in pro-growth signaling pathways and key metabolic pathways relative to non-tumorigenic differentiated cells, often due to loss of tumor suppressor genes and oncogenic driver mutations. The remodeled signaling and metabolic profiles of cancer cells support not only their aberrant proliferation, but also their survival. Further factors such as intra-tumoral heterogeneity, altered redox status, and epigenetic modifications all contribute to the ability of certain tumors to develop drug resistance and persist under standard treatments.
there are many other forms of treatment that can slow the cancer, but none that leave the patient completely cancer free
* Chemotherapy: Using special medicines or drugs to shrink or kill the cancer, Drugs include pills or IV. (Maybe both)
As the cancer continues to spread throughout society, many treatments are creating in order to help the patients during their time in need. Although the most popular and used often
“HIPEC enables us to administer a high concentration of chemotherapy right where the cancer cells live, rather than circulate it all around the body,” Dr. Labow said. “This allows for fewer side effects and better killing of the cancer cells. It can also reduce the need for regular chemotherapy, although it is usually given in addition to regular chemo, and not instead of it. It gives us a new option to fight the most difficult to treat cancers.”
Cancer is a disease in which cells multiply out of control and gradually build a mass of tissue called a tumor. There has been a large amount of research dedicated to the treatment and cure of cancer. Several types of treatments have been developed. The following are just some of the major examples of cancer therapy: surgery, chemotherapy, radiation therapy, biologic therapy, biorhythms, unconventional treatments, and hyperthermia. Each type of treatment is discussed in detail below.
Cancer occurrs by the production of multiple mutations in a single cell that causes it to proliferate out of control. Cancer cells often different from their normal neighbors by a host of specific phenotypic changes, such as rapid division rate, invasion of new cellular territories, high metabolic rate, and altered shape. Some of those mutations may be transmitted from the parents through the germ line. Others arise de novo in the somatic cell lineage of a particular cell. Cancer-promoting mutations can be identified in a variety of ways. They can be cloned and studied to learn how they can be controlled.