3-D printing came about in the 1980s (Atala & Murphy, 2014). This printing method made it possible to print materials in layers to eventually form a solid 3-D structure. The possibilities of this printing were considered for manufacturing products for consumers (Atala & Murphy, 2014). The original 3-D printers were capable of making objects, but these objects weren’t durable enough to last long (Harris, n.d.). The original printers were mainly used to create models. The process used to create these models was a “laser to solidify a polymer material extruded from a nozzle” (Harris, n.d.). It wasn’t until the 1990s that the different materials of metal and plastic were used together in conjunction with the computer following an engineer’s layout of the product. The new technical layout scheme and materials made it possible to produce a sturdier product that would last (Harris, n.d.). These new developments led to medical researchers considering the possibilities of producing human tissues and organs. The researchers realized that a human organ is a 3-D object with width, height, and depth that could be manufactured the same way car parts could (Harris, n.d.). There were multiple limitations to make a 3-D printer capable of producing human tissue or organs. A few restrictions were to find another material besides plastic that would last inside of a human and to make a machine that was capable of printing living human tissue without destroying the cells in the process.
As 3D printing transitions from commercial manufacturing use to personal private use individuals will have the ability to print any design. Products can range from a pair of shoes to complicated engineering designs, life-saving devices, prosthetic limbs and weapons that pass airport security. In the future we will likely see printable medications and
The field of bioprinting, using 3D printing technology for producing live cells with extreme accuracy, could be the answer to many of the problems we as humans face in the medical field. It could be the end to organ waiting lists and an alternative for organ transplants. In 3D printing technology lies the potential to replace the testing of new drugs on animals. However, the idea of applying 3 dimensional printing to the health industry is still quite new and yet to have a major impact. Manufacturing working 3D organs remains an enormous challenge, but in theory could solve major issues present today.
In a study conducted through the U.S. Department of Health and Human Services on “average 79 people will receive an organ each day; however, an average of 22 people die each day” waiting for transplants that cannot take place because of the shortage of donated organs (U.S. D.H.H.S). The average amount of patients waiting for an organ can reduce to zero with the continued development of 3-D printers. 3-D printing is a process of making three dimensional solid objects from a digital file. The digital file is uploaded onto a computer software, and then the 3-D printer prints the digital file out onto different materials. The materials include plastic, resin, nylon, sandstone. The finish products become replicas of the digital file, and what was an idea is now a reality. Therefore, 3-D printers will one day be the future of organ transplants because over the past twenty years the technology industry has rapidly grown into the focal point in society. From advancement in communication, to the medical field, science and technology has shaped this world today. Thus, the American Government should invest more money into the medical field budget because the research conducted on new technology (3-D Printers) leads to more lives saved, and expands the opportunity of future medical breakthroughs.
Secondly, advanced 3D printing applied to the medical field can be utilized in an Engels non capitalist technology drive society to impact the area of safety. In this utopian society, advanced 3D printing will have the capabilities to print synthetic tissue and organic tissue that can bond to the patient’s cells. In effect, this helps the patient’s wound heal faster. This type of advanced 3D bio printing can save many lives
Doctors and engineers have been working on another way to get organs a faster and more efficient way. Using 3D printers can help with their problem. They have worked on using a 3D printer to make organs that are a perfect match for patients. This can be very useful it can get an organ ready in a short amount of time helping the patient recovery faster as well. Organ transplants are hard to come by. One you have to be put in a waiting list, and people are usually on that list for a long while, just waiting for a perfect match to come. But sometimes it takes to long and some people die while still on the waiting list. But when an organ finally does come they feel bad because someone had to die in order for them to use it. So Dr Ali Khademhosseini is trying to use 3D printing to help solve this problem. His theory is he can make organs from a 3D printer, which can make the waiting list decrease faster and have people not have to die in order for a perfect match. 3D printers have been used to make Human cells, tissue, and blood vessels. But making something like a heart is much more difficult. Because you have to make the beating and pumps. (Mesley). There have been problems in the past that have just know started to show in some people. "Viruses aren't the only worry, and here too the past may serve as a guide. In 1956 injections of human growth hormone became a standard therapy for children failing to develop properly. The hormone was extracted from
The purpose of this experiment is to test how scientists can most efficiently complete organ printing. In this lab, the cells will be suspended in a substrate called sodium alginate-collagen, hydrogel, and other reactants. These materials will react to then embed the cells to their goal location. Then, the cells will be able to be fixated into layers. These layers will then come together and form tissues, which according to biological organization will form organs. The inkjet bioprinter allows for this to occur. Tiny ink droplets form a digital design for the organ printing, and in horizontal sheets, the organ is created tissue by tissue. This lab will test to see which percent concentration of the sodium alginate-collagen composite will prove to be most effective when organ printing. The dependent factor that will determine the conclusion will be the percent of efficiency of cell survival rate. Four trials will be completed in which the same organ is printed and all factors are kept constant, except for the percent concentration of the substrate.
Kaiba Gionfriddo was born prematurely in 2011. After 8 months, his lung development caused concerns, although he was sent home with his parents as his breathing was normal. Six weeks later, Kaiba stopped breathing and turned blue. He was diagnosed with tracheobronchomalacia, a long Latin word that means his that windpipe was so weak that it collapsed. He had a tracheostomy and was put on a ventilator – the conventional treatment. Still, Kaiba would stop breathing almost daily. His heart would stop, too. Then, his caregivers 3D printed a bioresorbable device that instantly helped Kaiba breathe. This case is considered a prime example of how customized 3D printing is transforming healthcare as
In the future, the technology will be widely accepted since it can be used to create complete organ, to test newly developed drugs on manufactured cells instead of animals and human cell, to imprint cells directly onto a human body, thus reducing the wait time for organ transplantation, and save time and cost associated with drug research. An absolutely favorable position of customized organs is designing organs utilizing a patient 's own particular cells. With this methodology, there would be no issues with dismissal, and patients wouldn 't need to take the powerful anti-rejection medications that are presently required (Cooper-White, 2015). According to the Organovo company, the formation of a suitable liver is a crunch second for the bio-printing and drug industry since it demonstrates 3D printed tissue can be preserved successfully for a sufficient time to test the impacts of medications on it or insert it in a human body where it can further mature (Mearian,2013).
Bioprinting offers the ability to create a 3D biomimetic tissue by patterning cells and, in some approaches, multiple cell types with precise and reproducible spatial control. In order to create these organs a researcher must start off with a bioink consisting of compounds with a chemical structure consisting of polysaccharides and/or proteins. Some of the compounds include, but are not limited to agar, collagen, silk, elastin, and chitosan. These bioinks are then infused with additives that include growth factors, cytokines, and extracellular matrix (Bioprinting 4-12). Bioprinting then “moves from the laboratory to the clinic sources, clinical grade cells will be necessary to support the assembly of different constructs” This is where stem cells from the patient, if possible, are utilized to prevent the use of immunosuppressive drugs. (Bioprinting 4-12). Once everything is loaded into the biopen, it is then loaded into the bioprinter (fig 1, 2). Researchers are then able to make tissues, organs, and many other structural components.
This is nothing new. In the past decade, clinicians, surgeons, and scientists have been collaborating with other disciplines to create parts of organs or artificial skulls from 3-dimensional bioprinters. Many promising signs of progress have been made, such as the success of reconstructing the skull of patients who suffer head trauma or neurological disease, or a functional trachea that response to
Unfortunately, this is the sad reality. Having the technology to utilize a 3-D printer to reconstruct a patient’s organ would prevent patients from having to wait for a donor organ. Being able to use the patient’s own cells to build his or her new organ would decrease the chances that the patient’s body will reject it. According to Thilmany (2012) indicated “the end goal here is the growing of a biocompatible piece of tissue to repair or replace a patient's own damaged body part, such as bone, cartilage, blood vessels, or skin” (p.
Anthony Atala, in his 2011 Ted Talk, Printing a Human Kidney, tells of printing a bladder. He explains that they use a small piece of the patients original bladder. They then print a scaffold and let the cells grow on the scaffolding in an “oven like device” that has the “same conditions as the human body -- 37 degrees centigrade, 95 percent oxygen” Weeks later, the organ has grown and it is ready to be placed in the patient. Atala explains that “For these specific patients, we actually just suture these materials. We use three-dimensional imagining analysis, but we actually created these biomaterials by hand.”Luke Massella, a patient who received a 3D printed organ because he was born with spina bifida that prevented his bladder and kidneys
The promise of printing human organs began in 1983 when Charles Hull invented stereolithography. This special type of printing relied on a laser to solidify a polymer material extruded from a nozzle. The instructions for the design came from an engineer, who would define the 3-D shape of an object in computer-aided design (CAD) software and then send the file to the printer. Hull and his colleagues developed the file format, known as .stl, that carried information about the object's surface geometry, represented as a set of triangular faces.
With the very limited supply of organs, 3D printing creates functioning organs without a donation from a living organism. The definition of 3D printing from Charles W. Hull, the inventor of 3D systems, states that “...thin layers of a material that can be cured with ultraviolet light were sequentially printed in layers to form a solid 3D structure” (Murphy & Atala 773). The sheer narrow sheets play a vital role in bioprinting. They allow the printers to develop functional, layering individual cells, proteins, and an extracellular matrix. The three basic types of 3D printing include biomimicry, independent self- assembly, and miniature tissue blocks. The creation of the 3D structure creates all the difference between these types of printing. Three dimensional structure approaches include, creating exact duplicates of the cells and tissues with extensive knowledge, using a developing embryo as a template or using microscopic tissues to assemble into a larger developed tissue (Kalaskar). In other words, all these paths to bioprinting end up with a 3D structure but require different knowledge and materials. They all contain their own sets of challenges.
3D printing is a technology that was invented in the early 1980s by a man named Charles Hull (Ventola, 2014). Since its creation, 3D printing has branched into many different aspects of the world and is being utilized in fields like the automotive industry, medicine and is even being used for everyday purposes. Later on, Charles Hull founded a company called 3D Systems which developed the first ever 3D printer. In 1988, Hull and his company 3D Systems, put forth the first commercially available 3D printer. From this point on, 3D printing would be advanced and evolved to the point where it would have the opportunity to create a revolutionary impact on the world we