One of the main diclofenac containing suppositories in the market is Voltarol which is available in different strengths. However, Voltarol does not have bioadhesive properties and it is not regarded as a fast acting formulation.
The conventional suppositories have problems related to the release of the drug. They take a long time to melt and release the drug leading to delayed therapeutic effects. Also, the suppositories have a reduced bioavailability and this is due to the unpredictable or incomplete absorption of the drug in the rectum. Furthermore, conventional suppositories have a poor retention in the lower rectum. This causes the suppository to migrate to the upper rectum making it more susceptible to first pass metabolism hence reducing