Wilson’s disease is a rare genetic disorder affecting about 1 in 30,000 people (Schilsky, 2014) in which excess copper accumulates in the body, notably the liver and the brain (Anon, undated). It is an autosomal recessive condition in which the ATP7B gene on chromosome 13 (EASL, 2012) is defective. There are around 500 known mutations that can cause this defectivity (Tidy, 2014). The ATP7B gene codes for a copper-transporting P-type ATPase usually found in hepatocytes (Huster, 2010) (Roberts & Schilsky, 2008) that excretes excess copper into bile (EASL, 2012) (Roberts & Schilsky, 2008). When this gene is defective, it causes copper to build up in the liver which can be transported in the bloodstream to other organs such as the brain …show more content…
Serum ceruloplasmin levels can be most accurately measured by assaying using the enzymatic route (Tidy, 2014). It can also be measured using antibody-dependant assays e.g. a radioimmunoassay. Such immunologic assays can be inaccurate, and give a higher concentration of ceruloplasmin because they cannot differentiate between apoceruloplasmin and holoceruloplasmin (EASL, 2012) (Roberts & Schilsky, 2008), 2 types of ceruloplasmin. A low serum ceruloplasmin level is not usually enough on its own to give a positive diagnosis for Wilson’s disease as there may be other causes such as autoimmune hepatitis (EASL, 2012). In many cases, Kayser-Fleischer rings can only be visible with a slit-lamp examination by an experienced observer (EASL, 2012) (Roberts & Schilsky, 2008) (Weiss, 2016). In many cases, however, other diagnostic techniques must be used. For example, 24-hour urinary copper excretion levels >1.6 µmol/24 h (or >0.64 µmol/24 h in children) can indicate Wilson’s disease (EASL, 2012). A liver biopsy core of at least 1-2 cm in length (to ensure measurement accuracy) may also be taken if non-invasive techniques are undiagnostic (EASL, 2012) (Roberts & Schilsky, 2008). Processing the sample and analysis using stains such
President Wilson's own ineptitude and stubbornness is what led to the Senate's defeat of the Treaty of Versailles, rather than the strength of the opposing forces. Even Wilson's closest and most trusted advisors could not sway his stance. Wilson was strong in his stance and incorporated the idea of the 14 points. While it is true that opposing forces contributed to defeat the treaty, it was Wilson's unmovable position that led to its ultimate defeat in the Senate.
“The Secret Lives of Sgt. John Wilson” by Lois Simmie, is a love story with a twist. It’s a true story of John Wilson. A man who loves but hates and lies to make himself look more superior then he really was. This story end with not only the murder of John’s wife Polly, but also in the hanging of John himself. Lois Simmie had many reasons for writing this book. She had heard many rumors about it and wanted to find out more. She felt the book was worthwhile writing because she had a personal connection to the story. Lois accomplished writing Sgt.John Wilson by proving the truth. “ Lois Simmie has woven a most intriguing tale about a mountie who was anything but credit to his force. Sgt. John Wilson may be a base character, but he is seductive”. (back of the book)
Wilson, a volleyball who became Chuck’s only companion as he was stranded was who kept him sane during the time they were together. Chuck’s physical needs were being met by Wilson as Chuck was able to maintain his ability to keep up with enough physical activity for him to be able to gather and create tools they would both need to survive, such as starting a fire. As Chuck Argues with Wilson, he fulfills his identity needs by believing that his argument makes him a more logical, smarter person. Chuck is also able to meet his social needs as he uses Wilson’s presence as a listening one he could use to share ideas he had throughout time.
Women’s suffrage was a huge controversy in the 1920s. Many women wanted the right to vote and their voice to be heard. This was the time where the flappers were in action. Women were loud, bold, and daring. All they needed was equal rights; they wanted equal pay, and mainly voting rights. During this time, President Wilson was in office. Wilson won the presidential election due to his view on women’s suffrage; he was completely against it. ("President Woodrow Wilson Picketed by women Suffragists.") On the other hand, his opponent, Roosevelt, supported women’s Suffrage. Throughout his time, his office, his view changed ("President Woodrow Wilson Picketed by Women Suffragists."). Wilson’s view on women’s suffrage changed dramatically but
Any person that can rise up from the bottom rung of the ladder to the top is able to achieve great things in life. Renowned playwright August Wilson, a winner of two Pulitzer Prizes, and other awards for his work, is an example of such persons. He grew up in a lower class black family, faced the difficulties of an African American, and turned himself into the great writer he is.
Two great men, two great presidents, led our nations to excellency and great success. Theodore Roosevelt and Woodrow Wilson were hard working, intelligent men who were very familiar, but were also different in many aspects. Through their dedication to our country and their passion of politics they have made our country better.
wrote the play Fences about his life: the heartbreaking reality of racism in his own life and the
Woodrow Wilson, our 23rd president, became involved in a war that he did not want any part of. Wilson wanted to remain neutral and have peace as in his first term of office. During World War I Wilson’s roles in the war became well known in all countries. Wilson wanted peace more than anything else. In seeking for peace Wilson asked Congress for the U.S. to enter World War I. which may not sound like a peace strategy but Wilson felt it was the only way to stop Germany and gain peace. Wilson wrote his speech for world peace, Fourteen Points, that he was probably most famous for. He attended and played an integral part in The Treaty of Versailles. He was the founder of the League of Nations,
In literature, slavery and the African American race are often analyzed and interpreted by numerous authors. Mark Twain reveals numerous hitches and aspects of society’s view towards different races throughout many of his novels. In Pudd’nhead Wilson Twain describes the status of African Americans in society, as well as how they are portrayed or believed to act in the eyes of other townsfolk. The portrayal of Roxy and the status of Tom and Chambers both help Twain show the wrongs of the
Woodrow Wilson was the first Southerner to be elected president after the Civil War. Born on December 28, 1856 in Staunton, Va., he was the son of a Presbyterian minister who supported the Confederates. Wilson assumed the presidency after a whirlwind career as a college professor, university president and New Jersey governor. However, Wilson left the Oval Office just as heartbroken as the Confederate soldiers that returned home when he was a boy.
Progressive hepatolenticular disease, or more commonly known as Wilson’s Disease, is a rare autosomal recessive genetic disorder of copper metabolism that is characterized by hepatic and neurological disease. While there is no cure for Wilson’s Disease, there are several treatments that can effectively manage the symptoms. The predominant form of treatment for Wilson’s Disease is heavy metal toxicity medication which utilize copper chelators to prompt the organs in the body to release copper into the bloodstream and excreted via urine after kidney filtration or zinc to reduce copper absorption (Ala et. al, 2007). Medications for Wilson’s Disease include penicillamine, trientine, and zinc acetate. Besides medications, other current therapeutic
Woodrow Wilson’s presidency was by many accounts one of the most successful in American history. Not only did his domestic affairs and reform policies give birth to the modern age of liberalism but his foreign policies would lead the United States to victory in World War I. This would in turn contribute to the United States involvement in world affairs.
“Lets Talk About Carl Wilson” We, as a society, hold many beliefs and ideas that structure our tastes. The individuals with whom we surround ourselves, the people who inspire us, popular as well as unpopular fads, and our knowledge about a topic are all pieces of a puzzles that fit together to construct our attractions and hatreds. As these influences change so do our tastes. Carl Wilson discusses this shift in perception as a central idea in the book Let’s Talk about Love: Why Other People Have Such Bad Taste. Although he focuses on his distaste for Céline Dion throughout the book, he only uses her as an example of his own rancors, because, as Paul Valéry puts it, ‘“tastes…are composed of a thousand distastes” (11).
An explanation of the title on the facing page ends with the sentence, "There is no joke or subtle meaning in the publisher's imprint."[4] This seems to be[according to whom?] an ironic joke-reference to the fact that every word on the frontispiece apart from the name of the publishing-house had been subjected to tortuous qabalistic self-exegesis, yet according to Robert Anton Wilson in his 1977 book Cosmic Trigger I: The Final Secret of the Illuminati:
upon how well you live, how long you will live and how you will look