Convulsions, hallucinations, anxiety, insomnia, sweating, vomiting, and even seizures—these withdrawal symptoms are endured regularly by people with extreme alcohol addiction. Alcoholism presents life-ravaging problems: negligence, anger issues, propensity for hazardous behavior, and longer recovery from alcohol use’s aftereffects (#1). Alcoholics exhibit diminished immunities and are at elevated risk for cancer, epilepsy, cardiovascular disease, HIV/AIDS, and more. Alcoholism is both devastating and alarmingly common, affecting 4-5% of the United States’ population (#2). Worldwide, it produces 2.5 million deaths annually and is the third largest cause for disability and premature death (#3). Long ago thought to be strictly behavioral, alcoholism is in fact a complex trait (#2). Like other complex traits, it develops due to mutations in “susceptibility genes” that interact intricately with environmental influences (#4). Alcoholism is derived roughly 50-60% from genes (#2). Genes impact a person’s alcohol tolerance and craving levels; the higher these two factors, the likelier he or she is to develop addiction (#5). Geneticists have uncovered alcoholism-inducing genes via linkage analysis, in which genomes from alcoholic and nonalcoholic members of families with histories of alcoholism were scanned at 400 areas. This technique helped researchers to locate quantitative trait loci, 10- to 20-million-base-pair–long nucleotide strands suspected to include the genes triggering
Alcohol use has spanned history. In fact, there is speculation that alcohol use actually preceded the formation of societies (Doweiko, 2015, p. 30). Thus, alcohol has long been a part of mankind’s life. The function of alcohol has unarguably changed throughout the course of history, as it was first used for nutritional purposes and then later on for religious purposes (Doweiko, 2015, p. 32). Today, alcohol serves a social purpose. In the United States, the prevalence of use is quite high, with just over 50% of the population partaking monthly (Doweiko, 2015, p. 34). This statistic is somewhat alarming considering alcohol use comes with a number of potential adverse consequences. Case in point, even
The article by Bierut et al. 2010 is a discovery science article, in which there are no hypotheses tested. This article focuses on alcohol dependence and the genetic influences that may contribute to the rapid growing dependency. Various case subjects were used to analyze the results from, the Collaborative Study on the Genetics of Alcoholism (COGA), Family Study of Cocaine Dependence (FSCD) in addition to the Collaborative Genetic Study of Nicotine Dependence (COGEND). This genome-wide association case study Bierut et. al analyzed various single nucleotide polymorphisms, likewise known as, SNPs, that are capable of being genetically linked to alcohol dependency. SNPs are nucleotides that contain genetic variation in the genome as well as, vary between individuals.
Prescott, C. A., Madden, P. A. F., & Stallings, M. C. (2006). Challenges in genetic studies of the etiology of substance use and substance use disorders: Introduction to the special issue. Behavior Genetics, 36(4), 473-482.
Alcoholism, in some way or another, affects everyone, as it is ever-present in nearly every aspect of American culture. Although there are numerous different opinions on the true main influence that causes alcoholism in an individual, it is an undeniable fact that alcoholism is an addiction, which is a disease of the mind. Alcoholism cannot be fought and cured in just a few days, it takes support from loved ones, willpower, and a competent treatment center. Alcoholism is not a game to be toyed with, is is a very serious issue, which affects many individuals and their families like mine throughout the U.S. I hope that you, whoever reads this essay, learned the biological factors that influence alcoholism, as well as the social and biographical
Addiction is a complex disease that is influenced by several factors including: genetic, developmental, experiential and environmental factors (Goldstein & Volkow, 2002). Alcohol dependence, otherwise referred to as alcoholism, is characterized by frequent use of alcohol resulting in intoxication, a preoccupation with alcohol, compulsion to seek and consume alcohol, the inability to limit alcohol intake and the emergence of negative emotional state when the drug is absent (Gilpin & Koob, 2008; Ernst et al., 2012; Kunce, & Newton, 1989; Crews, 2012). There is an estimated 85,000 deaths annually caused by unhealthy alcohol consumption. Medical issues such as liver disease, neurological problems and malignancies, in addition to behavioral and
Alcohol abuse is something that has affected countless lives, both mentally and physically. There are numerous disorders linked to this abuse, from Substance-Induced Anxiety Disorders to Alcohol-Induced Psychotic Disorder. These disorders have varying affects on the body and the person’s lives, and can cause serious injury and/or have serious side effects. A US Department of Justice study found that as many as 40% of violent crimes occur under the influence of alcohol. Of the 3.9 million Americans who received treatment for a substance abuse problem in 2005, 2.5 million of them were treated for alcohol use. Drinking alcohol to the point of dependence poses a severe health
Although the collection of findings from several types of genetically informative research designs does provide compelling evidence for the influence of genetics and heritability on the risk for addiction, they do
Most people have a confused idea of alcoholism as a disease that invades or attacks your good health. Use of such a strong word such as "disease" shapes the values and attitudes of society towards alcoholics. A major implication of the disease concept is that what is labeled a "disease" is held to be justifiable because it is involuntary. This is not so. Problem drinking is a habit in which the so-called "alcoholic" simply has decided that the benefits of drinking outweigh the liabilities; it is all a matter of personal choice. An alcoholic participates in or causes many of their own problems by their behavior and the decisions they make, so why should they be viewed as helpless victims of a "disease"(Skipper 1)? Alcoholism should not be
Contrary to popular belief, genetics account for about 50% of the likelihood that someone will develop an alcohol addiction. (Horvath, T.)
McGue (1999) found that genes contribute to the development of alcohol dependence, with heritability estimates from 50-60% for both men and women.
The Kalsi et al. (2008) article is a review article, therefore, lacking a hypothesis. The main idea was to identify various genes that are related to alcoholism and how they affect the brain. The first variant studied was DRD2, a dopamine receptor gene (Kalsi et al., 2008). This gene is known for being related to addiction and pleasures in life. It is not shocking to know that this gene is elevated in the nervous system, because alcohol raises the dopamine receptors and causes drinkers to feel as if they need more, thus increasing their happiness. Another gene discussed is the GABAA gene, a component of the GABRA2 gene. This component when found in AD, spikes an increase in tolerance level, thus creating an effect in the brain to encourage the individual to continue drinking. Once the tolerance levels have spiked, GABAA and another receptor gene, NPY will induce withdrawal behavior. These variants, if found at low levels, play a vital role in the onset of alcoholism. While understanding that the NPY gene may be found in the individuals, the CREB signaling pathway must also be discussed. They observed a study on rodents to drive a correlation between deficient genes and their correlation to humans. They observed this by analyzing the
Alcohol dependence is known to be the most severe form of alcohol abuse. A person becomes so dependent on alcohol consumption that he/she loses sight of all the other important things going on around him/her. Family matters and social responsibilities become secondary worries to his/her primary concern for existence, which is drinking (Stephens, 2007). Nearly fourteen million Americans are somewhat dependent on alcohol. Alcohol dependence is more prominent in men, and young adults ages 18-29 (Stephens, 2007). According to a study done by Saitz “85,000 deaths, along with substantial disability from medical and psychiatric consequences, injuries and “secondhand” effects (ex: motor vehicle crashes) are attributed to the use of alcohol” (Saitz, 2005).
The term “alcoholism” describes a drinker who is mentally and physically dependent on alcohol, and who would most likely have withdrawal symptoms upon trying to quit. This dependence prevents most alcoholics from being able to control when they drink and how much they drink. For that reason, alcoholics usually drink to excess despite the consequences. Alcoholism, like any addiction, is a chronic disorder which involves continued use despite negative consequences and requires ongoing treatment and management. This research paper will cover many aspects of alcoholism including the causes and effects of drinking and different treatment approaches.
In the United States, 17.6 million people – about one in every 12 adults, abuse alcohol or are alcohol dependent. (NIH: National Institute on Alcohol Abuse and Alcoholism, 2012) The Mayo Clinic defines alcoholism as a chronic disease in which your body becomes dependent on alcohol (Mayo Clinic Staff, 2010), and indicates that more than 100,000 Americans die annually from alcohol related causes (Johnson) . Aside from the physical problems that alcohol addiction can create, there are frequently emotional and social complications. Alcoholism is a disease that harms not only the alcoholic, but also the co-workers and family of the alcoholic.
Alcoholism has been a major problem in society for a number of years. In fact, alcoholism should be compared to a virus. This is because a person can never be completely cured from alcoholism; they can only fight the battle, day to day, hoping not to relapse. When it comes to the etiologies, or causes, of alcoholism, there seems to be three distinct origins of alcoholism. These causes are genetic factors, dependency caused by brain chemical imbalances after long-term use, and social and emotional factors.