. Relationship of Drug solubility & dissolution rate on Physico-Chemical Properties 2. Relationship of Particle size & effective surface area on Physico-Chemical Properties
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1. Relationship of Drug solubility & dissolution rate on Physico-Chemical Properties
2. Relationship of Particle size & effective surface area on Physico-Chemical Properties
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- 1. Explain the importance of solubility in drug product formulation. 2.___4.In briefly After analyzing the above pictures, identify the reasons for drug instability when kept at this warehouse.Drug X is available in two forms with the following aqueous solubilities: slightly solutble WA or a soluble Na salt of the WA. Which form of the drug is most appropriate for an oil based solution dosage form? a. WA b. Na salt of WA
- The clinical effectiveness of a drug majorly depends on: a. Clearance b. Potency c. Affinity to receptors d. Half-life15- Which of the followings is TRUE regarding "Therapeutic index" a.The value of therapeutic index can indicate the pharmacokinetics of the drug b.It is the ratio of effective dose/ toxic dose c.Drugs with low value of therapeutic index is a safe drug d.Low value of "therapeutic index" means that we need to monitor the patient carefullyWhat properties of drug are relevant for developing modified release drug delivery formulation. Please briefly explain this at your own words.
- 1. Create drug study of the following: CEFUROXIME PROPRANOLOL PARACETAMOL 2. Includes GENERIC NAME, CLASSIFICATION, PHARMACODYNAMICS, INDICATIONS AND 10 NURSING CONSIDERATIONS EACH DRUG.1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product? 2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product? 3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)? 4. How could the manufacturing process affect drug product performance? 5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived? 6. What is meant by “sink” conditions? 7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration? 8. For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be…Can you determine why some drugs have narrower spectra thanothers? (Hint: Look at their mode of action.)
- Explain the role of different toxicological parameters (i.e. ED50, TD50, LD50, NOAEL, LOAEL, etc.) in ensuring the safety of a drug candidate. Briefly explain this at your own wordsA patient needs to be given 5ml of drug x which is available at a concentration of 200mg/ml. The displacement value for drug x is 0.56ml/gWhat volume of water for injections should be added to the patients dose for it to be correctly reconstituted? units = ml Answer to 2 dpsWhat is Drugbank? https://go.drugbank.com/ A.A compendium of drugs that are commercially available. B.Drug Gene Interaction database C.FBI storage locker for illegal drugs D. A database of pharmaceutical knowledge about drugs.