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- Suggest the effects of each of the following mutations on the physiologicalrole of chymotrypsinogen:(a) R15S(b) C1S(c) T147SHemophilia B, an X-linked genetic disorder which highly affects males, is a condition in which levels of Factor VIII are significantly decreased. Please describe the physiologic pathway which utilizes Factor VIII and describe the consequences of missing this factor from a physiologic perspective.Present the rationale for clinical applications of niacin. What are major side effects?
- Give the biological activities and occurrence of prostaglandins and leukotrienes.Hydroxyurea has been shown to increase the expression of fetal hemoglobin in adult red blood cells, by a mechanism that remains unclear. Explain why hydroxyurea can be a useful therapy for patients with sickle-cell anemia.Describe the mechanism of action and pharmacokinetics of eicosanoids.
- Explain the function of histidine 57 in the mechanism of chymotrypsin.In 2-page worth of words (around 500), discuss CYCLAMATE's regulation, allowable levels, and what group of people are at high risk for the side effects of CYCLAMATE in the body.TPCK and TLCK are irreversible inhibitors of serine proteases. One ofthese inhibits trypsin and the other chymotrypsin. Which is which? Explainyour reasoning. Suggest the effects of each of the following mutations on the physiologicalrole of chymotrypsinogen:(a) R15S(b) C1S(c) T147S