How are the alarmones ppGpp and pppGpp synthesized?

Human Physiology: From Cells to Systems (MindTap Course List)
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ISBN:9781285866932
Author:Lauralee Sherwood
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Chapter19: The Peripheral Endocrine Glands
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How are the alarmones ppGpp and pppGpp synthesized?

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Alarmones are the intracellular molecules produced by the prokaryotes like bacteria and Archaea when they are exposed to the harsh environment.

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The stringent response is a mechanism by which cells adjust to new environments when facing a sudden decrease in the nutrient levels in the environment. It is a global control mechanism that brings about a course of events that help the cell to adapt to changing nutrient levels in the surrounding. The stringent response is mainly brought about by nucleotides called alarmones. The two alarmones that are synthesized are ppGpp (Guanosine tetraphosphate) and pppGpp (Guanosine pentaphosphate).

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