. Tay-Sachs disease is a rare human disease in which toxic substances accumulate in nerve cells. The recessiveallele responsible for the disease is inherited in a simpleMendelian manner. For unknown reasons, the allele ismore common in populations of Ashkenazi Jews ofeastern Europe. A woman is planning to marry her firstcousin, but the couple discovers that their sharedgrandfather’s sister died in infancy of Tay-Sachsdisease.a. Draw the relevant parts of the pedigree, and showall the genotypes as completely as possible.b. What is the probability that the cousins’ first childwill have Tay-Sachs disease, assuming that all peoplewho marry into the family are homozygous normal?
. Tay-Sachs disease is a rare human disease in which toxic substances accumulate in nerve cells. The recessive
allele responsible for the disease is inherited in a simple
Mendelian manner. For unknown reasons, the allele is
more common in populations of Ashkenazi Jews of
eastern Europe. A woman is planning to marry her first
cousin, but the couple discovers that their shared
grandfather’s sister died in infancy of Tay-Sachs
disease.
a. Draw the relevant parts of the pedigree, and show
all the genotypes as completely as possible.
b. What is the probability that the cousins’ first child
will have Tay-Sachs disease, assuming that all people
who marry into the family are homozygous normal?
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