1 Antigen in excess 4 Circulating immune complexes are trapped in the vessel walls. Antigen- Antibody- Endothelial cells Clump of immune complexes of blood vessel 2 Formation of immune complexes Neutrophils are attracted and release enzymes that cause tissue damage. Immune complex Neutrophils release enzymes. Activated complement causes basophils to release inflammatory mediators that increase vascular permeability. Complement activated Basophil Mediators O FIGURE 17.5 Type III Hypersensitivity: Immune Complex-Medlated When antigen is in slight excess (1), immune complexes form (2) and activate complement, resulting in increased vascular permeability (3). Immune complexes are trapped in the blood vessels (4) and complement attracts neutrophils that release enzymes, damaging the tissue (5). Complement in the blood Spaces created by dilation of blood vessel

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Immunology

Immunology is the division of science involved with the immune reactions occurring in living organisms. The organisms are accustomed to evolving internal defense mechanisms to evade the invasion of microbial pathogens. Diverse cells are connected with stimulating the immune responses, which produce inhospitable conditions to the microbes prompting their lysis and thus inhibits the multiplication of the pathogens. The immune system can distinguish the pathogens through the aid of cellular intercommunication and launch responses to destroy them.