
Concept explainers
Female patient whose is a 13-year-old, was admitted to the hospital with complaints of progressive weakness and shortness of breath with minimal physical effort. She has experienced recurrent fevers reaching 38.8°C. Physical examination reveals a well developed
teenage with good nutritional status and in no acute distress.
There is no lymphadenopathy or organomegaly. Many petechial
hemorrhages cover her chest and legs. Several bruises are found
on her legs and thighs. Laboratory tests were ordered upon admission. The laboratory tests result were as the following:
RBC 2.24 X1012 /l
Hb 71 g/l
PCV 24%
Plt 8.0 X109/l
WBC 1.2 X109/l
Differential
Segmented Neutrophils 2%
Lymphocytes 94%
Monocytes 4%
Reticulocyte count 0.7%
She was referred to a hematologist who ordered a bone marrow
examination. Bone marrow biopsy showed a markedly
hypocellular marrow with very few hematopoietic cells and there were no malignant cells present.
1- Is it likely that she has a congenital form of aplastic anemia? Explain your answer.
2- Evaluate each of the patient’s laboratory results by comparing
them to reference ranges?
3- Classify the morphologic type of anemia?
4- Predict a treatment for this patient?
5- What are other diseases may expected in this patient? What are the tests you could differentiate the aplastic anemia form these diseases?

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