4 1. A very common way to introduce an aldehyde group on an aromatic or alkenyl group is to reactthe appropriate organometallic reagent with N.N-dimethylformamide. Thinking about theintermediate formed by nucleophilic addition, why do you think that this might stop afteraddition and not immediately undergo substitution to give the aldehyde that would then reactfurther. Also, please draw this initial addition intermediate for the following reaction as well asthe final product.OMe2. AsI mentioned, there are many other alcohol protecting groups. One of these is the acetategroup. While the acidic H on the alcohol is removed, this is not a good protecting group fororganometallic chemistry. Why is that? Show what you think might happen in the followingreaction.Br-Mg°3. Electrophiles other than carbonyls will react with organometallic reagents. Dry lce (solid CO.) lo.Rartisulatis one that can be quite useful in forming carboxylic acids. For the following reaction,show the initial addition product and then explain why you think it does not just underga rapidsubstitution and then a second addition.Co2

Answered: Image /qna-images/answer/58980392-271e-4213-ac02-0575f9d2a999.jpg

1. A very common way to introduce an aldehyde group on an aromatic or alkenyl group is to react the appropriate organometallic reagent with N.N-dimethylformamide. Thinking about the intermediate formed by nucleophilic addition, why do you think that this might stop after addition and not immediately undergo substitution to give the aldehyde that would then react further. Also, please draw this initial addition intermediate for the following reaction as well as the final product. OMe

1. A very common way to introduce an aldehyde group on an aromatic or alkenyl group is to react the appropriate organometallic reagent with N.N-dimethylformamide. Thinking about the intermediate formed by nucleophilic addition, why do you think that this might stop after addition and not immediately undergo substitution to give the aldehyde that would then react further. Also, please draw this initial addition intermediate for the following reaction as well as the final product. OMe

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter16: Synthesis Workshop 1

Section: Chapter Questions

Problem 32CTQ

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