1. The Iron Response Factor (IRF) regulates production of both the iron transport protein transferrin and the iron storage protein ferritin in response to intracellular iron conditions, but its effect on the production of these two proteins is not the same. Describe or explain how the IRF can simultaneously lead to decreased production of the iron transport protein transferrin and increased production of the iron storage protein ferritin in response to high intracellular iron concentrations.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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1. The Iron Response Factor (IRF) regulates production of both the iron transport protein transferrin and the iron storage protein ferritin in response to intracellular iron conditions, but its effect on the production of these two proteins is not the same. Describe or explain how the IRF can simultaneously lead to decreased production of the iron transport protein transferrin and increased production of the iron storage protein ferritin in response to high intracellular iron concentrations. 

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