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- 44. Effects of clofibrate. High blood levels of triacylglycerides are associated with heart attacks and strokes. Clofibrate, a drug that increases the activity of peroxisomes, is sometimes used to treat patients with such a condition. What is the biochemical basis for this treatment? Please Demonstrate and explain.Factors Affecting Enzyme Activity: Catalase 3. What is the marker for the enzyme’s optimum condition?RECALL Several of the enzymes of glycolysis fall into classes that we will see often in metabolism. What reaction types are catalyzed by each of the following: (a) Kinases (b) Isomerases (c) Aldolases (d) Dehydrogenases
- Inhibition of Purine and Pyrimidine Metabolism by Pharmacological Agents Indicate which reactions of purine or pyrimidine metabolism are affected by the inhibitors (a) azaserine, (b) methotrexate, (c) sulfonamides, (d) allopurinol, and (e) 5-fluorouracil.Chapter: Lipid Metabolism Individuals with abnormally low levels of carnitine in their muscles suffer from muscular weakness during moderate exercise. In addition, their muscles have significantly increased levels of triacylglycerols. (a) Explain these two effects. (b) Can these individuals metabolize muscle glycogen aerobically?Importance of glucose-6-phosphate for metabolism, write the reactions obtained and show the regulations.
- 40. Which of the following statements about transition state analog inhibitors are true? MARK ALL THAT APPLY. Group of answer choices Provide insight into catalytic mechanisms. Very potent and specific inhibitors. They have difficulty binding to the active site because they resemble the energetically unstable transition state of the substrate. Can be used as immunogens to generate catalytic antibodies.2c which is altered by a catalyst such as an enzyme, the net free energy change of the reaction or the activation energy of the reaction?Most individuals with genetic defects in oxidative phosphorylation are found to have relatively high concentrations of alanine in their blood. how this in biochemical terms? please help :)
- 15. Ascorbic acid is considered a secondary antioxidant, since its role involves the reduction of tocopherols so these can keep exerting antioxidant activity. YET, ascorbic acid can also act as a PRO-OXIDANT. Provide an explanation with mechanisms regarding this ativity.38. Glycogen isolation 1. The liver is a major storage site for glycogen. Purified from two samples of human liver, glycogen was either treated or not treated with a -amylase and subsequently analyzed by SDS-PAGE and western blotting with the use of antibodies to glycogenin. The results are presented in the adjoining illustration on the next page. (a) Why are no proteins visible in the lanes without amylase treatment? (b) What is the effect of treating the samples with a - amylase? Explain the results. (c) List other proteins that you might expect to be associated with glycogen. Why are other proteins not visible?Pharmacokinetics of cyclophosphamide
