1. You are a lead engineer in a cGMP facility that develops and delivers tissue engineering constructs for tissue regeneration. You have been asked to develop an injectable tissue engineering solution for regenerating heart tissue following myocardial infarction. Describe an injectable tissue engineering solution to regenerate the damaged heart tissue by considering the following and give a brief explanation for your choices: i) Description of large animal model for myocardial infarction, including animal and method

1. You are a lead engineer in a cGMP facility that develops and delivers tissue engineering constructs for tissue regeneration. You have been asked to develop an injectable tissue engineering solution for regenerating heart tissue following myocardial infarction. Describe an injectable tissue engineering solution to regenerate the damaged heart tissue by considering the following and give a brief explanation for your choices: i) Description of large animal model for myocardial infarction, including animal and method

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter10: The Blood Vessels And Blood Pressure

Section: Chapter Questions

Problem 11RE

See similar textbooks

Similar questions

Describe why a doctor would give a patient that is diagnosed with acute myocardial infarction the treatment of tissue plasminogen activator(tPA)? What will it do?
Name three mechanisms that can increase cardiacoutput.
The exact cause of blood clotting in the left atrium of the heart during atrial fibrillation (AF) is not known. In part it might be due to blood stasis (not moving) or it may result in combination with endothelial cells damage. (A) What are the potential mechanisms that might drive clotting and what markers might you look for in the blood to predict potential risk? (B) Other than treating the arrhythmia, what other pharmacological intervention might be provided to AF sufferers?
All of the following are correct about the isovolumetric contraction, except ____________. A. This phase of the cardiac cycle begins with the appearance of the QRS complex of the ECG, which represents atrial repolarization and ventricular depolarization B. It represents the time period between the closure of the AV valves and the opening of the aortic and pulmonic valves, ventricular pressure rises rapidly without a change in ventricular volume C. The rate of pressure increase in the ventricles is determined by the rate of contraction of the muscle fibers, which is determine by mechanisms governing excitation-contraction coupling D. Ventricular chamber geometry changes considerably as the heart becomes more spheroid in shape; circumference increases and atrial base-to-apex length increases
In the nineteenth century, Poiseuille’s law was experimentally deduced byJ. L. M. Poiseuille, who was interested in understanding the flow of blood inhorses’ arteries.We nowknowthat Poiseuille’s lawis a poorway of modelingblood flow in arteries. In your own words, give at least three reasons whyPoiseuille’s lawis not appropriate for arterial blood flowmodeling, and brieflydiscuss why this is the case.
Discuss the mechanism underlying AP generation by cardiac autorhythmic cells
Give a detailed mechanism of action of a name drug or agonist that results in positive inotropic changes in the cardiac cell.
1. The source of the electrical currents that you measured on the skin throughout a normal electrocardiogram is: a. regional differences in depolarization state between parts of the myocardium b. The SA node cells c. the opening and closing of the tricuspid and bicuspid valves d. depolarizations of the muscle and nerve cells close to the electrode site e. The AV node cells 2. Release or discharge from which of the following is likely to produce a slowing in the rate at which the AV node transmits a depolarization? a. Your coffee cup (caffeine) b. the posterior lobe of the pituitary gland (Oxytocin) c. the sympathetic nervous system d. the parasympathetic nervous system (vagus nerve) e. the medulla of the adrenal gland (epinephrine) 3.Which of the following is unlikely to affect the force of contraction of an individual ventricular myocyte (muscle cell)? a. the amount of…
Discuss the differences between myogenic and neurogenic hearts and explain what the role of regulatory neurons is to control cardiac output. If possible, include in your answer examples from different organisms for each type of heart.
Mention four advantages and two limitations of capillary electrophoresis over HPLC.
17. Match the ECG wave information with the appropriate action potential in the following columns: a.P wave e.Depolarization of the AV node b.QRS complex f.Repolarization of ventricles c.PR segment g.Depolarization of ventricles d.T wave h.Depolarization of the atria Match the itmes in the left columns to the right columns.
Describe the mechanism of action of cardiac glycosides, such as digitalis.